Frontiers in Clinical Drug Research : CNS and Neurological Disorders / edited by Zareen Amtul.

Format:

Book

Author/Creator:

Amtul, Zareen, Author.

Contributor:

Amtul, Zareen, editor.

Series:

Frontiers in Clinical Drug Research - CNS and Neurological Disorders Series

Frontiers in Clinical Drug Research - CNS and Neurological Disorders Series ; Volume 11

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Physical Description:

1 online resource (339 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., 2023.

Summary:

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The eleventh volume of this series features reviews that cover the following topics related to the treatment of a variety of CNS disorders, related diseases, and basic research: - The Multi-target Directed Ligands candidate (MTDLs) prototypes for neurodegenerative diseases - Drugs for relapse prevention in addiction - Neuroprotective activities of cinnamic acids and their derivatives in neurodegenerative disorders - Phytosome for targeted delivery of natural compounds in treating alzheimer's disease - Physical activity as a non-pharmacologic method for treatment of alzheimer's disease.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases

Flávia Pereira Dias Viegas1,3, Vanessa Silva Gontijo1,2, Matheus de Freitas Silva1,3, Cindy Juliet Cristancho Ortiz1,3, Graziella dos Reis Rosa Franco1,3, Januário Tomás Ernesto1,2, Caio Miranda Damásio1, Gabriel Pinto da Silva Fonseca1, Isabela Marie Fernandes Silva1, Larissa Emika Massuda1, Maria Fernanda da Silva1, Thâmara Gaspar Campos1, Priscila da Mota Braga1 and Claudio Viegas, Jr.1,2,3,*

INTRODUCTION

THE MTDLS PARADIGM AND MOLECULAR HYBRIDIZATION (MH) AS A TOOL IN DRUG DESIGN

GENERAL ASPECTS OF MULTIFACTORIAL PATHOGENESIS IN NDS

Alzheimer's Disease (AD)

Parkinson's Disease (PD)

Amyotrophic Lateral Sclerosis (ALS)

Huntington's Disease (HD)

MOLECULAR HYBRIDS AND CHEMICAL DIVERSITY OF MULTIFUNCTIONAL LIGANDS RATIONALLY DESIGNED AS NEW DRUG CANDIDATES FOR NDS

CONCLUDING REMARKS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGMENTS

REFERENCES

Drugs For Relapse Prevention in Addiction:Review of Psychological and Neurological Factors,Genetics and Neurobiological Mechanisms

Neuroprotective Activities of Cinnamic Acids and their Derivatives

Pronit Biswas1,*, Rajesh Singh Yadav1 and Juli Jain2

CELL DEATH IN NEURODEGENERATION

CINNAMIC ACID

Naturally Occurring Cinnamic Acid Derivatives

Synthetic Derivatives of Cinnamic Acid

PHARMACOLOGICAL ACTIVITIES OF CINNAMIC ACIDS AND THEIR DERIVATIVES IN NEURODEGENERATIVE DISEASES

Parkinson's Disease

Alzheimer's Disease

Huntington's Disease

Prion Disease

Ischemic Brain Injury

FUTURE CHALLENGES

CONCLUSION.

CONSENT FOR PUBLICATION

ACKNOWLEDGEMENTS

Phytosome for Targeted Delivery of Natural Compounds: Improving Efficacy, Bioavailability, and Delivery across BBB for the Treatment of Alzheimer's Disease

Prashant Tiwari*, 1, Geetha KM1, Shweta Shrivastava2, Yogita Kumari2, Rajni Kant Panik3, Pankaj Kumar Singh4, Dileep Kumar5 and Pratap Kumar Sahu6

Conventional Therapy Against AD

Blood Brain Barrier and AD

Neuroprotective Potential of Herbal Drugs

Herbal Drugs Used in AD

Nanotherapeutics to Improve BBB Permeability

Polymeric Nanoparticles

Nanogels

Solid Lipid Nanoparticles

Nano Lipid Carrier

Target Specific Nanoparticles

Phytosome

Therapeutic Applications of Phytosome

Alzheimer's Disease and Physical Activity, Will the Symptoms Improve?

Maryam Hamzeloo-Moghadam1,*

Risk Factors

Pathology

Pharmacologic Treatment of Alzheimer's Disease

Cholinesterase Inhibitors

N-methyl-D-aspartate (NMDA) Receptor Antagonists

Should Non-Pharmacologic Treatments Be Involved?

Physical Function and Activities of Daily Living (ADL)

Fall Risk and Balance

Cognitive Function

Communication

Sleep Disturbance

Cardiorespiratory Improvement

Combination Therapy

Influence of Physical Activity on Risk for AD

CONCLUSION

Subject Index

Back Cover.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815123319

OCLC:

1382694986