TRiPs across epithelial and endothelial barriers in health and disease / Alexander V. Zholos, Ganna M. Tolstanova, editors.

Format:

Book

Contributor:

Tolstanova, Ganna M., editor.

Zholos, Alexander V., editor.

Series:

Cell biology research progress.

Cell Biology Research Progress

Language:

English

Subjects (All):

Epithelial cells.

Diseases.

Molecular microbiology.

Physical Description:

1 online resource (272 pages)

Place of Publication:

New York : Nova Science Publishers, [2021]

Summary:

"Life on Earth began some 4 billion years ago when the first primitive prokaryotes managed to isolate themselves from the rather hostile environment. The immediate challenge that these first life forms faced was to ensure an optimal balance between two apparently mutually exclusive tasks - protection and separation from the extracellular milieu on the one hand and an efficient exchange of ions, energy sources and metabolites with the very same milieu on the other hand. The commencing evolutionary progress had to address even more challenging problems, such as how to delegate specific cell functions to discrete structures inside of the cell, called organelles (such as the nucleus), and, at the level of multi-cellular organisms, to ensure proper separation of different cell types (e.g. those found in different tissues and organs) while ensuring efficient communication between them. In fact, the human body is highly compartmentalized, from the cell level where local signals are generated and propagated in a highly ordered manner, to the whole body level. This book aims to introduce the interested reader to the universe of these complex segregated compartments in mammals. It discusses how the integrity of different types of barriers - endothelial, epithelial - is normally maintained and what could go wrong when these barriers' permeability becomes abnormally low or high in different disease states. We will focus on several such barriers, which are well studied and which are pivotal for a healthy well-being. In particular, we will focus on the skin, airways, the gut barrier, the endometrium, and cardiovascular and urinary systems. Special reference throughout the book will be made to several most novel groups of potential molecular candidates for the correction of barrier-related dysfunctions, in particular Transient Receptor Potential channels. Hence the title of the book has a triple meaning - a trip in its common sense, TRP channels (as in TRiP database) and Translating Research Into Practice (TRIP). Our team of authors is comprised of physiologists, pharmacologists, biophysicists and medics, including the national representative of Ukraine in the European Crohn's and Colitis organization (ECCO) and a member of the Scientific Committee of the European Association of Urologists. We include clinical cases and discuss molecular and cellular mechanisms underlying such real-life problems in-depth"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Introduction to Various Barriers Existing in the Human Body and the Role of TRP Channels

References

Section I. Regulation of a Barriers' Integrity is About Team-Play of Different Molecules

Chapter 1

Overview of TRP Channels

Abstract

Introduction

Mammalian TRP Channels

Molecular and Functional Interactions of TRP Channels with Molecular Components of Cell-Cell Junctions

Acknowledgments

Chapter 2

Calcium-Dependent Regulation of Barriers' Integrity with Focus on TRP Channels

TRP Channels and Calcium Signaling

TRP Channels and Barrier's Integrity

TRPC4, TRPM3 and TRPM7

TRPV1

TRPV4

TRPA1

Conclusion

Chapter 3

Inflammation and Its Mediators

Inflammatory Mediators and Vascular Permeability Mechanisms

Chronic Inflammation: Focus on Macrophages

TRP Channels and Inflammatory Response

Canonical (TRPC) Subfamily

Vanilloid (TRPV) Subfamily

Melastatin (TRPM) Subfamily

Ankyrin (TRPA) Subfamily

Chapter 4

Gut Microbiota and Gap/Tight Junctions

Regulation of a Barrier's Integrity Is About Team-Play of Gut Microbiota

Diet and Intestinal Mucus Affect Microbiota Composition

Immune System Affects Microbiota Composition

Communication Strategy of Microbiota

Regulation of a Barrier's Integrity Is About Team-Play of Different Molecules: Gap/Tight Junctions

Section II. Epithelial Barriers

Chapter 5

Role of TRP Channels and Calcium Signalling in Skin and Airways

TRP Channels in Health and Disease of the Skin.

TRP Channels Found in Airways and Their Roles in Respiratory Diseases

Chapter 6

Versatile Gut Barrier: One Barrier - Many Diseases

Intestinal Mucosal Barrier: Focus on Short Chain Fatty Acids

TRP Channels Are Candidate Fatty Acid Sensors

Intestinal Mucosal Barrier Function in Irritable Bowel Syndrome

Intestinal Mucosal Barrier Function in Inflammatory Bowel Diseases

Intestinal Epithelial Barrier Function in Urinary Tract Diseases

Intestinal Barrier and Recurrent Urinary Tract Infections

Intestinal Barrier and Chronic Kidney Disease

Intestinal Barrier and Oxalate Homeostasis in Chronic Kidney Disease

Chapter 7

The Exquisite Sensitivity of the Uterine Epithelium: Pregnant vs. Non-Pregnant Status of the Endometrium

Expression of TRP Channels in the Endometrium

TRP Channels in Functioning of the Endometrium

TRP Channels in Pathogenesis of the Reproductive Abnormalities

Chapter 8

The Maze of the Epithelial Layers in the Kidney and Urethra

Introduction to the Human Urothelium: An Unsolved Puzzle of Complex Structures and Functions

TRPs in Urinary Tract Physiology and Pathology

Urothelial Barrier Dysfunction and Urinary Tract Diseases

Therapeutic Targeting of TRP Channels and the Urothelial Barrier in Urinary Tract Disease

Section III. Endothelial Barriers

Chapter 9

Role of Myoendothelial Gap Junctions in Vascular Tone Regulation with Special Focus on Hypoxia

Types of Intercellular Connections

Role of Gap Junctions in Vascular Tone Regulation with Special Reference to Hypoxic Pulmonary Vasoconstriction.

References

Chapter 10

Role of Endothelial Barriers in Health and Disease Including Arterial Hypertension, Diabetic Vascular Disease, Ionized Irradiation Impact and COVID-19 Intervention

Arterial Hypertension and Gap Junctions

Diabetes Mellitus and Endothelial Malfunction

Ionizing Irradiation-Induced Genotoxic Oxidative Stress and Endothelial Malfunction

Selective Impairment of the Nitric Oxide-Induced Endothelium Dependent Vascular Relaxation (EDRF/NO) after Ionizing Irradiation and Relative Stability of the EDHF Component

Electrophysiological Studies of Endothelial Cells Obtained from Irradiated Animals

Endothelial Dysfunction is, Possibly, a Major Determinant of COVID-19 Intervention

Editors' Contact Information

Index

Blank Page.

Notes:

Description based on print version record.

ISBN:

1-68507-139-2

OCLC:

1267337783