Frontiers in cardiovascular drug discovery. Volume 6. / M. Iqbal Choudhary.

Format:

Book

Author/Creator:

Choudhary, M. Iqbal, author.

Series:

Frontiers in Cardiovascular Drug Discovery

Language:

English

Subjects (All):

Cardiovascular emergencies.

Physical Description:

1 online resource (256 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2022]

Summary:

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Cardiovascular Effects of Ranolazine and the Scope for Translational Research: A Current Review of Literature

Rebecca Pratiti1,*, Parul Sud1, Mohammad Yousef1 and Ankush Moza2

RANOLAZINE

MECHANISM OF ACTION

Effects on Late Sodium Current

Effect on Metabolism

Dosage Formulations, Pharmacodynamics and Pharmacokinetics

Side Effects

General Side Effects

Tolerability of Ranolazine

Drug-drug Interaction

QT-prolonging Effects

Animal Studies CHRONIC STABLE ANGINA (CSA)

ACUTE CORONARY SYNDROME (ACS)

ATRIAL FIBRILLATION

Rhythm Control for Atrial Fibrillation in the Presence and Absence of other Medications

Post-operative Atrial Fibrillation (POAF) in Patients Undergoing Cardiac Surgery

CARDIOMYOPATHY

Chemotherapy-induced Cardiomyopathy

Hypertrophic Cardiomyopathy

ARRHYTHMIAS

LONG QT SYNDROMES (LQTS 3)

Pathophysiology

Efficacy

HEART FAILURE (HF)

Heart Failure with Preserved Ejection Fraction (Diastolic)

Heart Failure With Reduced Ejection Fraction (Systolic) GLYCEMIC EFFECTS

Mechanism of Action

Effect on Glycated Hemoglobin A1c (HbA1c)

Modifier effect of Metformin

OTHER ADDITIONAL EFFECTS OF RANOLAZINE

FUTURE IMPLICATIONS

Gaps in Translational Research

Possible Causes of Inefficacy in Studies

CONCLUSION AND SUMMARY

LIST OF ABBREVIATIONS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Rho/Rho Kinase Signaling Pathway and Disease: from Bed to Bench

Yiming Wang1,#, Yuqing Zhang2,# and Dingguo Zhang3,*

INTRODUCTION

BIOLOGICAL EFFECTS OF RHO PROTEIN

Rho Protein Classification Rho Protein Structure and Activity Regulation

Downstream Effector Molecules of Rho

RHO KINASE

Structure and Classification of Rho Kinases

Regulation Mechanism of Rho Kinase Activity

Rho Kinase Inhibitor

RHO/RHO KINASE AND CARDIOVASCULAR DISEASE

Rho/Rho Kinase and Hypertension

Rho/Rho Kinase and Pulmonary Hypertension

Rho/Rho Kinase and Atherosclerosis

Rho/Rho Kinase and Myocardial Ischemia Reperfusion Injury

Rho/Rho Kinase and Adriamycin-induced Heart Injury

Outlook

RHO KINASE AND ISCHEMIC CEREBROVASCULAR DISEASE The Mechanism of Rho Kinase in Cerebral Ischemia

Rho Kinase Mediates Oxidative Stress

Rho Kinase Mediated Cytoskeleton Changes

Rho Kinase Mediates Inflammatory Response

Rho Kinase Regulates Phosphatidylinositol Metabolism

Rho Kinase Regulates the Expression of eNOS

Rho Kinase Regulates the Expression of Matrix Metalloproteinase-9

Neuroprotective Effect of Rho Kinase Inhibitor

RHO KINASE AND RESPIRATORY DISEASES

Rho Kinase and COPD

Rho Kinase and Asthma

Rho Kinase and IPF

Rho Kinase and Lung Cancer

Conclusion and Prospect.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9789815036909

9815036904

OCLC:

1355222369