Probiotics in Anticancer Immunity / edited by Mitesh Kumar Dwivedi, A. Sankaranarayanan, and Sanjay Tiwari.

Format:

Book

Author/Creator:

Dwivedi, Mitesh Kumar, Author.

Contributor:

Dwivedi, Mitesh Kumar, editor.

Sankaranarayanan, A., editor.

Tiwari, Sanjay, editor.

Series:

Frontiers in Cancer Immunology Series

Frontiers in Cancer Immunology Series ; Volume 3

Language:

English

Subjects (All):

Probiotics--Therapeutic use.

Probiotics.

Immunology.

Physical Description:

1 online resource (301 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., 2023.

Summary:

Probiotics have been suggested to be involved in both prevention and treatment of various human cancers. Probiotics in Anticancer Immunity explains biochemical mechanisms of anticancer immunity exerted by probiotics in various human cancers. It presents edited chapters focused on the evidence of probiotic use against human cancers through several animal and human studies. Part 1 of Probiotics in Anticancer Immunity consists of 11 chapters. The introductory chapters provide information about the link between gut microbiota and the host immune system in cancer and the general mechanisms of anticancer immunity exerted by probiotics. Subsequent chapters are focused on probiotics' anticancer immunity in specific cancers such as, skin cancer, stomach cancer, breast cancer, lung cancer, head and neck cancer, liver cancer, cervical and colon cancer. Key features - Gives a new dimensions and insight in the role of probiotics in anticancer immunity towards various human cancers - Provides several color figures and tables to clearly explain relevant information. - Includes recent information with new insights and references - Meets the needs of basic (pre-clinical) and advanced clinical researchers and postgraduate scholars.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Gut Microbiota and Host Immune System in Cancer

Shakti Prasad Pattanayak1,*, Gaurav Ranjan1, Priyashree Sunita2 and Pritha Bose3

1. INTRODUCTION

2. HUMAN HEALTH AND DISEASE: ROLE OF GUT MICROBIOTA

2.1. The Human Microbiome in Health

3. THE ROLE OF THE HUMAN MICROBIOME IN CANCER INDUCTION

3.1. Human Microbiome and Gastrointestinal Malignancy

3.1.1. Gastric Cancer

3.2. Colorectal Cancer

3.3. Oesophageal Cancer

4. FUNCTION OF GUT MICROBIOTA IN HOST PHYSIOLOGY AND METABOLISM OF NUTRIENTS

5. ISOLATION OF INTESTINAL MICROBES IN DIETARY METABOLIZATION

5.1. Omics Approaches

5.2. Metagenomics

5.3. Meta Transcriptomics

5.4. Meta-proteomic

5.5. Metabolic Summarizing (metabolomics/ Metabonomics)

6. THE CROSSTALK BETWEEN IMMUNE SYSTEM AND MICRO- BIOTA

7. MECHANISM OF GUT MICROBIOTA IN ANTICANCER IMMUNITY

7.1. Improvement of Antitumor Immunity

7.2. Inflammation Reduction

7.3. Systemic Genotoxicity Reduction

7.4. Stimulation Of Anti-tumor Signalling Pathways

8. INTERLINK OF CANCER RISK WITH MICROBIOME

8.1. Induction of Inflammation

8.2. Immunosuppression

8.3. Protumorigenic Environment Development and Genotoxin Aggregation

9. GUT MICROBIOME AND ALLEVIATION OF IMMUNE CHECK- POINT INHIBITION RESISTANCE IN CARCINOMA IMMUNO- THERAPY

9.1. Cancer Immunotherapy

9.2. The Gut Microbiota is Linked to ICI Treatment Sensitivity

10. CHALLENGES OF MICROBIOME RESEARCH IN CANCER IMMUNOTHERAPY

10.1. Preclinical Model

11. NEW INSIGHTS ON THE MODULATION OF THE GUT MICROBIOTA AND THE SUPPRESSION OF IMMUNOLOGICAL CHECKPOINTS IN CANCER

CONCLUSION

CONSENT OF PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENT

REFERENCES.

Mechanism of Probiotic Action in Anticancer Immunity

Mangala Lakshmi Ragavan1 and Nilanjana Das1,*

1.1. Gut Microbiome

1.2. Current Status of Cancer and Treatments

2. PROBIOTIC STRAINS USED FOR CANCER TREATMENT

3. MECHANISM OF PROBIOTICS ON CANCER IMMUNITY

3.1. Modifications of Gut Microbiota

3.2. Immunomodulation

3.3. Metabolic Activity

3.4. Enhancement of Intestinal Barrier Function

3.5. Production of Anti-carcinogenic Compounds

3.6. Degradation of Carcinogenic Compounds

3.7. Influence on Harmful Enzymes

4. ANTICANCER ACTIVITY OF PROBIOTICS

4.1. Production of Inhibitory Substances By Probiotics

4.2. Efficacy of Probiotics During Cancer Treatment

5. BIOTHERAPEUTIC DRUGS FOR CANCER

CONSENT FOR PUBLICATION

REFERENCES

Probiotics Based Anticancer Immunity in Skin Cancer

Engkarat Kingkaew1 and Somboon Tanasupawat1,*

2. SKIN CANCERS

2.1. Classification of Skin Cancer

2.2. Pathophysiology of Skin Cancer

3. SKIN MICROBIOME AND SKIN CANCER

4. GUT MICROBIOME AND ITS IMPLICATIONS IN SKIN CANER

5. PROBIOTIC BASED THERAPEUTIC APPROACHES

5.1. Probiotics and their Beneficial Roles

5.2. Probiotics and Microorganisms of The Skin

5.3. Role of Probiotics' Metabolites (Postbiotics) in Cancer Prevention

5.3.1. Exopolysaccharides (EPSs)

5.3.2. Short-chain Fatty Acids (SCFAs) and Lipids

5.3.3. Bacteriocins

5.3.4. Cell-wall Compounds

5.4. Role of Probiotics in the Prevention of Skin Cancer

Probiotics-based Anticancer Immunity In Colon Cancer

Sujitra Techo1, Engkarat Kingkaew2 and Somboon Tanasupawat2,*

2. PROBIOTICS AND THEIR SELECTION

3. COLON CANCER.

4. IMMUNOMODULATORY EFFECT OF PROBIOTICS

5. MECHANISMS OF PROBIOTICS IN THE PREVENTION AND/OR TREATMENT OF COLON CANCER

5.1. Enhancement of The Host's Immune Response

5.2. Suppression of the Enzymatic Activity of Pathogenic Bacteria

5.3. Regulation of Proliferation and Apoptotic Responses of Colon Cancer Cells

5.4. Protection of Intestinal Mucosal Barrier of Host

5.5. Inhibition of Carcinogenic Agents

6. PROBIOTICS USED FOR COLON CANCER PREVENTION AND/OR TREATMENT

ACKNOWLEDGEMENTS

Probiotics Based Anticancer Immunity in Colorectal Cancer

Prashant Shankar Giri1 and Mitesh Kumar Dwivedi1,*

2. PATHOGENESIS OF COLORECTAL CANCER

3. CORRELATION BETWEEN THE GUT MICROBIOTA AND COLO- RECTAL CANCER

3.1. Dysbiosis of Gut Microbiota in Colorectal Cancer

4. ROLE OF PROBIOTICS IN COLORECTAL CANCER

4.1. Animal Model Studies

4.2. Human Clinical Trials

5. PROBIOTICS MECHANISMS INVOLVED IN TREATMENT OF COLORECTAL CANCER

5.1. Regulation of Apoptosis

5.2. Inhibition of Tumor Cell Proliferation

5.3. Modulation of Host Immune Response

5.4. Short Chain Fatty Acids (SCFAs)

5.5. Reduction of Microbial Infection

5.6. Inactivation of Carcinogenic Compounds

5.7. Regulation of Tyrosine Kinase Pathway

6. FUTURE PERSPECTIVES

CONCLUSIONS

Probiotics-based Anticancer Immunity in Breast Cancer

Nosheen Masood1,* and Saima Shakil Malik2,*

2. GUT MICROBIOME

3. BREAST MICROBIOME

4. MILK MICROBIOME

5. MECHANISMS OF MICROBIAL MODULATION IN ANTI-TUMOR IMMUNE RESPONSES BY PROBIOTICS

6. MICROBIOME EFFECTS AND APPLICATIONS IN BREAST CANCER.

7. BENEFICIAL MODULATION OF ANTI-TUMOR IMMUNE RESPO- NSES BY PROBIOTIC BACTERIA

Probiotics Based Anticancer Immunity In Stomach Cancer

Shilpi Singh1, Bindu Kumari2, Sonal Sinha3, Gireesh Kumar Singh2, Suaib Lqman1,* and Dhananjay Kumar Singh2,*

2. EPIDEMIOLOGY OF STOMACH CANCER DEVELOPMENT, SYMPTOMS AND RISK FACTORS

2.1. Incidence and Mortality

2.2. Geographical Variability and Trends

2.3. Symptoms

2.4. Risk Factors

2.5. Diagnosis, Prevention and Treatment

2.5.1. Eradication of H. Pylori Infection

2.5.2. Diet Improvement

2.5.3. Early Detection

3. HISTOPATHOLOGY OF STOMACH CANCER

3.1. Sporadic Type

3.2. Early-onset Gastric Cancer

3.3. Gastric Stump Cancer

3.4. Hereditary Diffuse Gastric Cancer

4. TUMOUR-IMMUNE MILIEU IN STOMACH CANCER

5. GUT MICROBIOTA DYSBIOSIS IN STOMACH CANCER

6. ROLE OF PROBIOTICS IN STOMACH CANCER MANAGEMENT

6.1. Anticancer Mechanism of Probiotics

7. CURRENT PROBLEMS AND PROSPECTS

Probiotic-based Anticancer Immunity In Hepato- cellular Carcinoma (liver Cancer)

Firdosh shah1 and Mitesh Kumar Dwivedi1,*

2. ROLE OF GUT MICROBIOTA IN LIVER DISEASES

3. ROLE OF GUT MICROBIOTA IN HEPATOCELLULAR CARCINO- GENESIS

3.1. Gut Microbial Dysbiosis and Bacterial Metabolite Production in Hepatocellular Carcinogenesis

3.2. Immunomodulation in Hepatocellular Carcinogenesis

3.3. Toll-like Receptors (TLRs) in Hepatocellular Carcinogenesis

4. BENEFICIAL ROLE OF PREBIOTICS IN TREATMENT OF HEPATOCELLULAR CARCINOMA

4.1. Role of Prebiotics Fructans and Butyrate in Hepatocellular Carcinoma.

5. PROBIOTICS AS A THERAPEUTIC APPROACH FOR TREATING HEPATOCELLULAR CARCINOMA

5.1 Probiotics Helps In Improving Intestinal Dysbiosis

5.2 Probiotics Mediate Modulation of SCFAs Production

5.3 Probiotics Help in The Regulation of Th17 Response in HCC

5.4. Role of Probiotics in Binding or Adsorption to Carcinogens

ACKNOWLEDGMENT

Probiotics-based Anticancer Immunity In Cervical Cancer

Mehran Mahooti1,2, Elahe Abdolalipour1, Seyed Mohammad Miri1 and Amir Ghaemi1,*

2. PATHOGENESIS OF HPV AND CERVICAL CANCER

3. PROBIOTICS

4. PROBIOTIC AND CERVICAL CANCER (WITH A FOCUS ON POSSIBLE ANTI-CERVICAL CANCER MECHANISM OF PROBIOTICS)

5. PROBIOTIC AND CERVICAL CANCER (IN VITRO STUDIES)

6. ANTI-CERVICAL CANCER EFFECT OF PROBIOTICS IN THE CONTEXT OF PRECLINICAL STUDIES

7. PROBIOTICS AGAINST CERVICAL CANCER AND SIDE EFFECTS ASSOCIATED WITH CLINICAL CERVICAL CANCER THERAPIES

Probiotics-based Anticancer Immunity In Lung Cancer

Rabinarayan Parhi1,*, Suryakanta Swain2, Suvendu Kumar Sahoo3, Sandip Prasad Tiwari4 and Rajni Yadav4

2. LUNG CANCER

3. DRIVERS OF LUNG CANCERS

3.1. Genetic and Mutation Drivers

3.2. Microbial Drivers

3.2.1. Lung microbiome and its relation with gut microbiome

3.2.2. Immunity of Lung

3.2.3. Microbial Contribution To Lung Cancer

4. PROBIOTICS

4.1. Ideal Properties of Probiotics

4.2. Mechanisms of Action of Probiotics

4.3. Probiotics in Lung Cancer

4.3.1. Direct Action of Probiotics in the Treatment of Lung Cancer

4.3.2. Indirect Action of Probiotics in Lung Cancer Therapy

4.4. Advances in Probiotic Therapy in Lung Cancer.

4.5. Safety Aspects of Probiotics.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815124781

9815124781

OCLC:

1382693462