Polycaprolactone : applications, synthesis and characterization / Krishna Pramanik, editor.

Format:

Book

Contributor:

Pramanik, Krishna, editor.

Series:

Materials Science and Technologies

Language:

English

Subjects (All):

Polycaprolactone.

Tissue engineering.

Biomedical materials.

Physical Description:

1 online resource (358 pages)

Edition:

1st ed.

Place of Publication:

New York, NY : Nova Science Publishers, Inc., [2022]

Summary:

"This book provides an overview of the advances in the synthesis of PCL, PCL-based biomaterials, and designing of appropriate PCL structures keeping in view of their applications in biomedical (orthopaedic implant), tissue engineering including bone, cartilage, skin, and cornea, protecting agent for material for medical devices and food packaging. The book shall be of special interest to material scientists, tissue engineers, medical scientists, mechanical engineers and biotechnologists with a better understanding of the physico-chemical and biological characteristics of PCL biomaterial to develop more appropriate and innovative, PCL-based composite materials for a wide field of applications. I hope the researchers, scientists, medical/healthcare professionals and industries shall find all these contributions interesting and will be inspired from reading to broaden their research towards the PCL- based material development and manufacturing of innovative products and devices from these materials"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Advancements in the Synthesis of Polycaprolactone

Abstract

Introduction

Synthesis of PCL

Polycondensation of 6-Hydroxycaproic Acid

Ring-Opening Polymerization of ε-CL

General Mechanism of ROP

Transesterification Side Reaction of ROP

Catalysts Used in ROP

Radical Ring Opening Polymerization of Cyclic Ketene Acetals

Advancement in Synthesis of PCL

Conclusion

References

Chapter 2

Developments in Electrospun Polycaprolactone-Based Composite Materials for Bone Tissue Engineering Applications

Bone Tissue Engineering

Scaffold Requirements for Bone Tissue Engineering

Architecture

Porosity

Mechanical Properties

Degradability

Biocompatibility

Polycaprolactone (PCL): Synthesis and Physicochemical Properties

Synthesis

Physicochemical Properties

Modifications of PCL

Electrospun PCL-Based Scaffolds as Bone Regenerative Scaffolds

Bioceramics Incorporated Electrospun PCL Scaffolds

Drug Incorporated Electrospun PCL-Based Scaffolds

Growth Factor Incorporated Electrospun PCL-Based Scaffolds

Electrospun PCL Blends with Natural and Synthetic Polymers

In Vitro and In Vivo Responses of PCL-Based Scaffolds in Bone Defect Management

Chapter 3

Polycaprolactone-Based Shape Memory Polymers: A Review of Biomedical Applications

General Concept of Shape Memory Polymers

Shape Memory Polymer Structure and General Mechanism

Multi-Shape Behavior and Shape Reversibility

Self-Healing Functionality

Chemically Crosslinked Shape Memory Polymers

One-Way Shape Memory Polymers

Acrylate-Acrylate Photo-Crosslinking

Thiol-ene Michael Addition

Radiation Crosslinked SMPs

Others

Stress-Free Two-Way Shape Memory Polymers.

SMPs with Thermo-Reversible Dynamic Covalent Bonds

Diels Alder Reaction

Triazolinedione (TAD) Reaction

Hindered Urea Bond

Alkoxyamine Bonds

Disulfide Bonds

Transesterification Using Organic Base Catalyst

SMPs with Photo-Reversible Dynamic Covalent Bonds

Medical Applications

Bone and Cartilage Tissue Engineering

Tissue Engineering Using Dynamic Surface Topography

Tissue Engineering Using Thermo-Responsive Surface Charge

Biodegradable Stents and Scaffolds

Future Applications and Current Limitations

Non-Covalently Crosslinked Shape Memory Polymers

Multi-Block Copolymers

Therapeutic Drug Delivery

Tissue Engineering

Polymer Blends

Biodegradable Self-Knotting Polymer

Biodegradable Self-Expandable Polymer

Biodegradable Multiple-Shape Memory Polymer Blend

Endoluminal Sealant

Interpenetrating Polymer Networks

Self-Healing Effect in Semi-IPNs

Ionic Crosslinked SMPs

Supramolecular Polymers

Multilayered Shape Memory Polymers

4D Printing of PCL-Based Shape Memory Polymers

Extrusion-Based 4D Printing of PCL-Based SMPs

Overview of Extrusion-Based 4D Printing

Application of Fused Deposition Modelling (FDM)

Application of Direct Ink Write (DIW) Printing

Vat Photo-Polymerization Based 4D Printing of PCL-Based SMPs

Overview of Vat Photo-Polymerization for 4D Printing

Application for Stents and Scaffolds

Application for Self-Healing SMPs

Future Prospects of 4D Printing Techniques

Chapter 4

Current Developments in Polycaprolactone-Based Biomaterial Generation, Scaffolding, and Biomedical Applications for Bone Tissue Regeneration

Introduction.

PCL and PCL-Based Co-Polymers Synthesis and Characterization

Fabrication of PCL-Based Scaffold by Various Scaffolding Techniques

Solvent Casting and Porogen Leaching

Phase Separation

Additive Manufacturing

Surface Modification and Blends of PCL

Plasma Treatment

Chemical Treatment

Coating of Electrospun PCL Meshes

Blends of PCL

PCL-Based Composites for Bone Tissue Engineering

PCL-TCP

PCL-Hydroxyapatite

PCL-Bioglass Composites

In-Vivo Behaviour and Success of PCL-Based Composites

Chapter 5

Polycaprolactone-Based Composite Biomaterials and their Applications in the Treatment of Arthritis

Degradation of PCL

Treatments for Arthritis

Alleviative Treatment

Drug Delivery Systems

PCL Nanoparticles and Microparticles

PCL Micelles

PCL Implants

PCL Hydrogels

PCL Nanofibres

Regenerative Treatment

Tissue Engineering Using Monophasic Constructs

Tissue Engineering Using Multiphasic Constructs

Chapter 6

Applications of Polycaprolactone in Corneal Tissue Engineering

Corneal Anatomy and Physiology

Corneal Epithelium

Corneal Stroma

Corneal Endothelium

Properties of Corneal Scaffolds

Availability

Biodegradability

Scaffold Geometry

Water Content

Surface Area

Optical Transparency

PCL as a Biomaterial

Properties of PCL

PCL in Corneal Tissue Engineering

Modification of PCL

Tissue-Engineered Corneal Constructs

Epithelial Constructs

Stromal Constructs

Endothelial Constructs

Clinical Application

Conclusion and Future Perspective

Chapter 7

Polycaprolactone as a Biomaterial for the Treatment of Articular Cartilage Damage

Abstract.

Introduction

Role of PCL in Articular Cartilage Repair and Regeneration

PCL Based Biomaterials

Polycaprolactone (PCL)

Crosslinking Strategies to Enhance Mechanical Stability of PCL

In Vitro and In Vivo Application of PCL- Based Scaffold for Articular Cartilage Regeneration

Sources of Cells

Other Cell Sources

In Vitro and In Vivo Potentialities for Articular Cartilage Repair

Clinical Application and Future Scope

Chapter 8

Polycaprolactone-Based Nanocomposites for Electromagnetic Interference Shielding

Electromagnetic Interference Shielding

Brief Overview on Electromagnetic Interference

EMI in General Electrical and Electronic Systems

EMI in Medical Devices

Effects of EM Radiation on Living Beings

General Mechanism of EMI Shielding

EMI Shielding Effectiveness

Reflection Loss

Absorption Loss

Multiple Internal Reflection Loss

Factors Related to Shielding Effectiveness

Return Loss

Skin Depth

Relative Permittivity and Dielectric Loss

Relative Permeability and Magnetic Loss

Eddy Current Loss

Magnetic Hysteresis Loss

Resonance Loss

Polymer Composites for EMI Shielding

Overview of Conducting Polymer Composites (CPCs)

Factors Determining Shielding Effectiveness

Intrinsic Properties of Polymers

Filler Content and Electrical Percolation Threshold

Size, Shape, and Structure of Inorganic Fillers

Multiple Interfaces

Design Strategies for Internal Micro-Structure in CPCs

Uniform Structure

Porous or Foam Structure

Segregated Structure

Multi-Component Systems

Multiple Polymers and Multi-Phase Systems

Multiple Filler Components

Multilayered Architecture

Pre-Fabricated or Pre-Formed Conductive Network

Polycaprolactone-Based Polymer Composites for EMI Shielding.

Overview of Poly(ε-caprolactone)

Physical and Mechanical Properties

Intrinsic Electrical Properties

Smart Polymer Functionalities

Current Advances in PCL-based CPCs for EMI Shielding

Electrically Conductive Metal Nanomaterials

Carbon Allotropes

Carbon Black

Carbon Nanotubes and Hybrid Materials

Two-Dimensional MXene

Ceramic-Based Hybrid Materials

Magnetic Materials

Ferromagnetic Hybrid Materials

Antiferromagnetic Materials

Chapter 9

Potential Applications of Polycaprolactone as Food Packaging Material

Active Food Packaging System

PCL for Active Packaging of Food Material

Antimicrobial and Antioxidant Property

Barrier Properties

Biodegradation Property

Commercial Application of PCL as Food Packaging Material

Future Trends

Chapter 10

PCL-Based Electrospun Nanofibrous Scaffold for Skin Tissue Engineering

Current Approaches for Wound Healing

Fabrication and Characterization of PCL-Based Nanofibrous Scaffold for Skin Tissue Engineering

Herbal Extract/Drug-Loaded PCL Electrospun Scaffold/Mat for Skin Tissue Engineering

Some Antibiotic Drug-Loaded Scaffolds

Doping Based PCL Electrospun Scaffold/ Mat for Skin Tissue Engineering

PCL-Based Scaffolds with Different Polymers for Skin Tissue Engineering

PCL-Gelatin and PCL-Collagen-Based Nanofibrous Scaffolds

PCL-Chitosan-Based Scaffolds for Skin Tissue Engineering

PCL-PVA-Based Scaffolds for Skin Tissue Engineering

Some Other PCL-Based Nanofibrous Scaffolds for Skin Tissue Engineering

PCL-CZF-NPs

Nylon-PLGA-PCL

PCL-Starch

PCL-PDBTT

PCL-CNT

About the Editor

Index

Blank Page

Blank Page.

Notes:

Description based on print version record.

Other Format:

Print version: Pramanik, Krishna Polycaprolactone: Applications, Synthesis and Characterization

ISBN:

9798886971194