Considerations for developing a dosimetry-based cumulative risk assessment approach for mixtures of environmental contaminants / National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency.

Format:

Book

Government document

Contributor:

National Center for Environmental Assessment (Cincinnati, Ohio)

United States. Environmental Protection Agency. Office of Research and Development

Language:

English

Subjects (All):

Environmental risk assessment--Mathematical models.

Environmental risk assessment.

Genre:

technical reports.

Technical reports

Technical reports.

Physical Description:

1 online resource ([220] pages) : illustrations

Place of Publication:

Cincinnati, OH : National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 2007, released 2009.

Summary:

[The report] addresses the justification for developing physiologically based pharmacokinetic (PBPK) models for cumulative risk assessment. Chemical interactions in the body can alter the response observed, but the likelihood of an interactions is often most dependent on exposure. Results from these models can explain the basis for chemical interactions and can predict their likelihood at low, environmental exposures. This report identifies some key points to be considered when deciding whether to use PBPK modeling in a cumulative risk assessment.

Notes:

"EPA/600/R-07/064."

"September 2007."

Title from title screen (viewed Apr 8, 2009).

Includes bibliographical references.

OCLC:

318062527