Marks' basic medical biochemistry : a clinical approach / Michael Lieberman, Allan Marks, Alisa Peet ; illustrations by Matthew Chansky.

Format:

Book

Author/Creator:

Lieberman, Michael, 1950- author.

Marks, Allan D., author.

Peet, Alisa, author.

Contributor:

Chansky, Matthew, illustrator.

Language:

English

Subjects (All):

Biochemistry.

Clinical biochemistry.

Clinical medicine.

Clinical Medicine.

biochemistry.

Medical Subjects:

Biochemistry.

Clinical Medicine.

Physical Description:

1 online resource (ix, 1014 pages) : color illustrations

Edition:

Fourth edition.

Other Title:

Basic medical biochemistry, a clinical approach

Place of Publication:

Philadelphia, PA : Lippincott Williams & Wilkins, [2013]

Language Note:

English.

Summary:

"This core textbook helps medical students bridge the gap between biochemistry, physiology, and clinical care. The strength of Mark's Basic Medical Biochemistry is that it starts with the patient--the metabolic and nutritional needs of the human body (easy for students to understand)--as opposed to explanations of complex chemical theory. Mark's Basic empahsizes clinical correlations throughout the text and links biochemical concepts to physiology and pathophysiology, using patient vignettes as the context. These specific and memorable mock patient cases are followed throughout the chapter to pose questions, illustrate core concepts, and help students remember and apply biochemical priniciples within the context of clinical practice"--Provided by publisher.

Contents:

Metabolic fuels and dietary components

The fed or absorptive state

Fasting

Water, acids, bases, and buffers

Structures of the major compounds of the body

Amino acids in proteins

Structure–function relationships in proteins

Enzymes as catalysts

Regulation of enzymes

Relationship between cell biology and biochemistry

Cell signaling by chemical messengers

Structure of the nucleic acids

Synthesis of DNA

Transcription: Synthesis of RNA

Translation: Synthesis of proteins

Regulation of gene expression

Use of recombinant DNA techniques in medicine

The molecular biology of cancer

Cellular bioenergetics: ATP and O₂

Tricarboxylic acid cycle

Oxidative phosphorylation and mitochondrial function

Generation of adenosine triphosphate from glucose: Glycolysis

Oxidation of fatty acids and ketone bodies

Oxygen toxicity and free radical injury

Metabolism of ethanol

Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones

Digestion, absorption, and transport of carbohydrates

Formation and degradation of glycogen

Pathways of sugar metabolism: Pentose phosphate pathway, fructose, and galactose metabolism

Synthesis of glycosides, lactose, glycoproteins, and glycolipids

Gluconeogenesis and maintenance of blood glucose levels

Digestion and transport of dietary lipids

Synthesis of fatty acids, triacylglycerols, and the major membrane lipids

Cholesterol absorption, synthesis, metabolism, and fate

Metabolism of the eicosanoids

Integration of carbohydrate and lipid metabolism

Protein digestion and amino acid absorption

Fate of amino acid nitrogen: Urea cycle

Synthesis and degradation of amino acids

Tetrahydrofolate, vitamin B₁₂, and S-adenosylmethionine

Purine and pyrimidine metabolism

Intertissue relationships in the metabolism of amino acids

Actions of hormones that regulate fuel metabolism

The biochemistry of erythrocytes and other blood cells

Blood plasma proteins, coagulation, and fibrinolysis

Liver metabolism

Metabolism of muscle at rest and during exercise

Metabolism of the nervous system

The extracellular matrix and connective tissue.

Notes:

Includes bibliographical references and index.

Print version record.

Other Format:

Print version: Lieberman, Michael, 1950- Marks' basic medical biochemistry. Fourth edition

ISBN:

145117358X

9781451173581

OCLC:

847232913

Access Restriction:

Restricted for use by site license