Spectral CT Thermometry for Real-Time, Non-Invasive Temperature Monitoring of Thermal Ablation Leening P Liu

Format:

Book

Thesis/Dissertation

Author/Creator:

Liu, Leening P., author.

Contributor:

University of Pennsylvania. Bioengineering., degree granting institution.

Language:

English

Subjects (All):

Medical imaging.

Oncology.

0574.

0992.

Local Subjects:

Medical imaging.

Oncology.

0574.

0992.

Physical Description:

1 electronic resource (246 pages)

Contained In:

Dissertations Abstracts International 86-07B

Place of Publication:

Ann Arbor : ProQuest Dissertations and Theses, 2024

Language Note:

English

Summary:

Percutaneous thermal ablation is an effective treatment for focal tumors but can result in local tumor recurrence associated with insufficient heating of tumor and a surrounding margin of healthy tissue. Real-time, non-invasive temperature monitoring with spectral CT thermometry may reduce this local tumor recurrence rate by providing a volumetric temperature distribution to ensure complete ablation. To develop spectral CT thermometry, a spectral physical density quantification model was developed and implemented to relate physical density to temperature through the principle of thermal volumetric expansion in ex vivo bovine muscle. Liver-mimicking phantoms were also evaluated for model reproducibility and temperature tolerance at different radiation dose levels to meet clinical requirements. A metal artifact reduction algorithm was then designed specifically for the ablation probe and spectral CT data. Finally, microwave ablation was performed on an in vivo porcine liver to assess the feasibility of spectral CT thermometry for non-invasive temperature monitoring under physiological conditions. Spectral CT thermometry was validated in ex vivo bovine muscle, demonstrating thermal volumetric expansion with a Pearson's correlation coefficient of 0.9781. Liver-mimicking phantoms similarly exhibited a strong relationship between physical density and temperature, which was reproduced in three separate phantoms with a coefficient of variation of 9.6% and 0.08% for the slope and intercept, respectively. Additionally, for slice thicknesses less than 5 mm, radiation dose necessary to meet temperature tolerance requirements was reduced from > 20 mGy to 2 mGy by applying external denoising. Implementation of the designed metal artifact reduction algorithm decreased streaks in the periphery and along the axis of the probe, reducing temperature overestimation by 8.1 ± 3.4 °C. In vivo ablation showed a strong relationship between temperature and physical density with a Pearson's correlation coefficient of 0.8785. Overall, development and characterization of spectral CT thermometry have demonstrated the utility of its accurate temperature maps, enabling clinical translation of non-invasive temperature monitoring to ensure complete ablation of tumor and ablation margin, and thus reduce local tumor recurrence

Notes:

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Advisors: Noel, Peter B. Committee members: Karp, Joel S.; Gang, Grace Jianan; Soulen, Michael C.

Ph.D. University of Pennsylvania 2024

Local Notes:

School code: 0175

ISBN:

9798302184047

Access Restriction:

Restricted for use by site license