New Developments in Redox Biology : Fundamental Roles in Health and Disease.

Format:

Book

Author/Creator:

Duttaroy, Asim K.

Contributor:

Jena, Atala Bihari.

Language:

English

Physical Description:

1 online resource (609 pages)

Edition:

1st ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2025.

Summary:

New Developments in Redox Biology: Fundamental Roles in Health and Disease serves as a vital resource for understanding the profound impact of the redox system on human biology.

Contents:

Front Cover

New Developments in Redox Biology

Copyright Page

Contents

Preface

I. The redox theory of developmental biology

1 The role of oxygen availability in embryonic development

1.1 Introduction

1.2 Role of oxygen in development

1.2.1 The role of oxygen in the early embryonic phase of development

1.2.2 Oxygen's role as a developmental morphogen

1.2.3 Oxygen homeostasis and regulatory mechanisms

1.2.4 Oxygen-regulated angiogenesis during embryonic development

1.2.5 Developmental programs subject to oxygen's contextual dependency

1.2.6 Pathways responding to oxygen availability in developmental processes

1.2.7 Influence of oxygen levels on viability of embryonic cells

1.3 Conclusion

References

2 Balancing of oxidants via antioxidant enzymes in developmental biology

2.1 Introduction

2.2 Oxidative free radicals/oxidants

2.2.1 Hydrogen peroxide

2.2.2 Malondialdehyde

2.2.3 Hydroxyl radical

2.2.4 Redox biology in developmental processes

2.3 Antioxidants

2.3.1 Enzymatic antioxidants

2.3.2 Nonenzymatic antioxidants

2.3.2.1 Ascorbic acid

2.3.2.2 Glutathione

2.3.2.3 Melatonin

2.3.2.4 Vitamin E

2.3.2.5 Xanthene

2.3.3 Natural-synthesized antioxidants

2.4 Antioxidants and oxidants in development

2.4.1 Role of superoxide dismutase in development

2.4.2 Role of catalase in development

2.4.3 Glutathione in development

2.4.4 Glutathione peroxidase in development

2.4.5 Role of lipid peroxidation in development

2.5 Conclusion

3 Antioxidant-mediated O2 sensing epigenetic regulation

3.1 Introduction

3.2 Oxygen sensing mechanisms

3.3 Antioxidants and redox balance

3.4 Interplay between antioxidants and oxygen sensing

3.5 Epigenetic regulation of oxygen sensing.

3.5.1 Antioxidant-mediated epigenetic regulation of oxygen sensing

3.6 Therapeutic perspectives and future directions

3.7 Conclusion

4 Genetic basis of phenotypic plasticity in embryo under stress

4.1 Introduction

4.2 Developmental biology and redox regulation

4.3 Genetic basis of phenotypic plasticity

4.4 Redox regulation of phenotypic plasticity

4.5 Molecular mechanisms of redox signaling

4.5.1 Reactive oxygen species generation

4.5.2 Redox-active molecules

4.5.3 Redox-sensitive proteins

4.5.4 Redox-sensitive signaling pathways

4.5.5 Cellular responses

4.6 Redox-sensitive transcription factors and their role in gene expression regulation

4.6.1 Nuclear factor-kappa B

4.6.2 Activator protein-1

4.6.3 Nuclear factor erythroid 2-related factor 2

4.6.4 Hypoxia-inducible factor 1

4.7 Crosstalk between redox signaling pathways and other cellular signaling networks in embryos

4.7.1 MAPK/ERK pathway

4.7.2 PI3K/Akt pathway

4.7.3 NF-κB pathway

4.7.4 Wnt/β-catenin pathway

4.8 Case studies and experimental approaches

4.9 Clinical implications and future directions

4.10 Conclusion

5 Cellular signaling cascade regulating embryonic development under oxidative stress

5.1 Introduction

5.2 Foundations of embryonic development

5.3 Understanding oxidative stress during embryonic development

5.4 Cellular responses to oxidative stress

5.5 Role of redox signaling pathways in cellular adaptation

5.6 Consequences of oxidative stress-induced damage and repair mechanisms

5.7 Crosstalk between signaling pathways

5.7.1 Autoregulation of antioxidant gene expression

5.7.2 Redox buffering systems

5.7.3 Negative feedback in signaling pathways

5.7.4 Epigenetic regulation

5.8 Impact of oxidative stress on embryonic development.

5.9 Regulation of embryonic signaling cascades

5.10 Therapeutic perspectives and future directions

5.11 Potential targets for therapeutic intervention

5.12 Emerging technologies for studying and manipulating embryonic signaling cascades

5.13 Conclusion

6 Intracellular signaling cascade shielding against oxidative stress

6.1 Introduction

6.1.1 Overview of oxidative stress

6.1.2 Significance of cellular signaling in stress response

6.2 Oxidative stress and cellular damage

6.2.1 Reactive oxygen species and their role

6.2.2 Consequences of oxidative stress on cellular components

6.2.3 The link between oxidative stress and diseases

6.3 Cellular defense mechanisms

6.3.1 Antioxidant enzymes

6.3.1.1 Superoxide dismutase

6.3.1.2 Catalase

6.3.2 Nonenzymatic antioxidants

6.3.2.1 Glutathione

6.3.2.2 Vitamins C and E

6.3.3 Cellular repair processes

6.4 Intracellular signaling pathways

6.4.1 Mitogen-activated protein kinase pathway

6.4.2 Nuclear factor erythroid 2-related factor 2 pathway

6.4.3 Phosphoinositide 3-kinase/protein kinase B pathway

6.4.4 c-Jun N-terminal kinase pathway

6.5 Regulation of gene expression

6.5.1 Activation of transcription factors

6.5.2 Upregulation of antioxidant genes

6.5.3 Adaptive responses to oxidative stress

6.6 Functional impact on cellular survival

6.6.1 Maintenance of cellular homeostasis

6.6.2 Protection against apoptosis and cell death

6.6.3 Preservation of cellular functions

6.7 Clinical implications

6.7.1 Diseases associated with oxidative stress

6.7.2 Dysregulation of signaling cascades in pathological conditions

6.7.3 Therapeutic approaches targeting signaling pathways

6.8 Current research and future directions

6.8.1 Recent advances in understanding signaling cascades.

6.8.2 Unexplored aspects and areas for future research

6.8.2.1 Spatial and temporal dynamics

6.8.2.2 Noncanonical signaling pathways

6.8.2.3 Role of microbiome in cellular signaling

6.8.2.4 Influence of mechanical forces

6.8.2.5 Role of Long noncoding RNAs

6.8.2.6 Systems biology approaches

6.8.2.7 Signaling in disease states

6.8.2.8 Epigenetic regulation of signaling

6.8.2.9 Emerging technologies

6.8.2.10 Immunometabolism and signaling

6.8.2.11 Extracellular vesicles in signaling

6.8.2.12 Cross-species signaling comparisons

6.8.2.13 Signaling in stem cell fate decisions

6.8.2.14 Role of nongenetic cellular memory

6.8.3 Technological innovations in studying cellular signaling

6.9 Conclusion

7 Stem cell homeostasis and differentiation under oxidative stress

7.1 Introduction

7.2 Stem cell biology primer

7.3 Oxidative stress and its impact on stem cells

7.4 Oxidative stress and pluripotent stem cells

7.5 Role of oxidative stress in stemness of pluripotent stem cells

7.6 Role of stress in somatic reprogramming in stem cell

7.7 Oxidative stress in hematopoietic stem cells

7.7.1 Role of oxidative stress in hematopoietic stem cell fate decisions

7.7.2 Role of oxidative stress in hematopoietic stem cell motility

7.8 Oxidative stress in stem cell aging

7.9 ER stress and stem cells

7.10 Reative oxygen species-mediated signaling pathways in stem cell regulation

7.11 Maintenance of stem cell homeostasis under oxidative stress

7.12 Regulation of stem cell differentiation in an oxidative environment

7.13 Molecular mechanisms and regulatory pathways

7.14 Therapeutic strategies and clinical applications

7.15 Stem cell-based therapies for oxidative stress-related diseases

7.16 Engineering stem cells for enhanced resistance to oxidative stress.

7.17 Challenges and future directions in translating stem cell research into clinical practice

7.18 Conclusion

8 Multiomics signature to oxidative response in cell growth and development

8.1 Introduction

8.2 Genomics insights into oxidative response

8.3 Epigenomics of oxidative stress

8.3.1 Epigenetic modifications in response to oxidative stress, including DNA methylation and histone modifications

8.3.2 Role of chromatin remodeling complexes in modulating oxidative stress response

8.3.3 Influence of oxidative stress on noncoding RNA expression and function

8.4 Proteomics landscape of oxidative response

8.4.1 Posttranslational modifications and protein-protein interactions involved in oxidative stress signaling

8.4.2 Identification of oxidative stress biomarkers through proteomic analysis

8.5 Metabolomics perspective on oxidative stress

8.5.1 Metabolic alterations induced by oxidative stress

8.5.2 Role of metabolic pathways in modulating oxidative stress and cellular redox homeostasis

8.6 Integrative analysis of multiomics data in oxidative stress

8.6.1 Systems biology approaches for modeling and predicting cellular responses to oxidative stress

8.6.2 Application of machine learning and network analysis in identifying key regulators of oxidative stress pathways

8.7 Clinical implications and therapeutic strategies

8.7.1 Development of personalized medicine approaches based on multiomics profiling

8.7.2 Therapeutic strategies targeting oxidative stress pathways for disease prevention and treatment

8.8 Future directions and challenges

8.9 Conclusion

II. Redox biology modulating noncommunicable diseases

9 Origin of cancer stem cells concerning hypoxia

9.1 Introduction to hypoxia and cancer stem cells.

9.2 Overview of cancer stem cells: definition, properties, and significance in cancer biology.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

0-443-43885-4

OCLC:

1528957600