Proteostasis : Investigating Molecular Dynamics in Neurodegenerative Disorders / edited by Nidhi Puranik.

Format:

Book

Author/Creator:

Puranik, Nidhi.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Biology.

Biological Sciences.

Local Subjects:

Biological Sciences.

Physical Description:

1 online resource (627 pages)

Edition:

1st ed. 2025.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2025.

Summary:

This book explores the role of proteostasis in neurodegenerative disorders, focusing on protein homeostasis in long-lived, nondividing cells like neurons. It examines how disruptions in proteostasis, influenced by factors such as oxidative stress, aging, and environmental stress, contribute to diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. The book begins with an overview of the epidemiology and management of neurodegenerative diseases. Subsequent chapters delve into the mechanisms governing proteostasis, highlighting the ubiquitin-proteasome system, molecular chaperones, and co-chaperones in protein folding and degradation. It further explores how impairments in these pathways contribute to neuroinflammation and disease progression. By providing insights into these cellular processes, the book aims to enhance understanding and support the development of potential therapeutic strategies.

Contents:

1. Neurodegenerative disorder: An overview

2. Alzheimer's: Epidemiology, pathophysiology, diagnosis and treatments

3. Parkinson’s Disease: Epidemiology, Pathophysiology, Diagnosis, and Treatment

4. A Proteasome System and Impairment in Ubiquitin-Proteasome System in Neurodegeneration and Neuroprotection

5. Protein misfolding and cell death in neurodegenerative diseases: consequences and strategies

6. Proteostasis disturbances and inflammation in neurodegenerative diseases

7. Proteostasis: Investigating Molecular Dynamics in Neurodegenerative Disorders

8. Biomarkers for Proteostasis Disruption: An Overview

9. Insights into Proteostasis System in Ageing and Neurodegenerative Disorders

10. The role of chaperones and cochaperones in synaptic proteostasis and neurodegenerative disease

11. Proteasomal Degradation and Autophagy in Neurodegenerative Diseases

12. The Insight into the Role of Protein Misfolding and Tau Oligomers in Alzheimer's Disease

13. Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease

14. A comprehensive review of the ubiquitin-proteasome system in synapse remodeling and neurodegenerative diseases

15. Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases

16. Ameliorative Effects of Heat Shock Proteins in Therapeutic Implications of Neurodegenerative Diseases

17. Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

18. Future Perspectives and Challenges in the Field of Proteostasis and Neurodegenerative Disorders.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Puranik, Nidhi Proteostasis

ISBN:

9789819662029

OCLC:

1528956528