Urine : Promising Biomarker Source for Early Disease Detection / edited by Youhe Gao.

Format:

Book

Author/Creator:

Gao, Youhe.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Proteins.

Biomedical Research.

Protein Biochemistry.

Local Subjects:

Biomedical Research.

Protein Biochemistry.

Physical Description:

1 online resource (563 pages)

Edition:

2nd ed. 2025.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2025.

Summary:

This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarker is measurable changes associated with the disease. Blood, as a critical part of the internal environment, is closely monitored and controlled by the body to maintain homeostasis, especially in the early stages of diseases. In contrast, urine, as a form of waste excreted by the body, accumulates early and small changes of the body without homeostatic control. Accordingly, urine can offer an ideal resource for early biomarker discovery. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems. It is useful for scientists, clinicians, venture capitalists of related field. In the 2nd edition, most of the chapters are updated and reorganized according to the latest research. Many new chapters have been added to supplement the discussion of this area.

Contents:

Chapter 1. Factors beyond science in the development of urine biomarkers

Chapter 2. Human Urine proteome a powerful source for clinical research

Chapter 3. Comparison of Urinary Proteomes Among Three Animal Models

Chapter 4. Urimem, a membrane that preserves urine for largescale biomarker study

Chapter 5. Posttranslation Modifications of Human Urine

Chapter 6. Application of Peptide Level and Posttranslational Modifications to Integrative Analyses in Proteomics

Chapter 7. BiomarkerExtractor a deep learning-based model for text mining of urine biomarkers

Chapter 8. Why are there proteins in urine

Chapter 9. Changes in the urine proteome in an acute hypoxic rat model

Chapter 10. Analysis of the active alterations in the urinary proteome of rats during the immunization process

Chapter 11.Urine Glucose Levels Are Disordered Before Blood Glucose Level Increase Was Observed in Zucker Diabetic Fatty Rats

Chapter 12. Comparison of urine proteomes from tumor-bearing mice with those from tumor-resected mice

Chapter 13. Progress in the application of urine proteomics in cancer biomarker discovery

Chapter 14. Urine proteome application in neurodegenerative diseases biomarker discovery

Chapter 15. Urinary Proteome Biomarker Discovery in Autism

Chapter 16. Progress of urinary proteome research in respiratory diseases

Chapter 17. Changes of urinary proteome in acute and chronic pulmonary inflammation

Chapter 18. Changes of urinary proteome in global cerebral ischemia-reperfusion injury

Chapter 19. Urinary complement factor D is increased in primary malignant hypertension

Chapter 20. The application of urinary proteomics in early detection of digestive diseases

Chapter 21. Application of urine proteome in biomarker discovery for cardiovascular diseases

Chapter 22. Comparison of urinary proteomes among three rat models of abdominal infection bacteria

Chapter 23. Serial Changes of Urinary Proteome in Animal Models of Renal Diseases

Chapter 24. Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury

Chapter 25. Using one–to–many urine proteome comparisons to provide clues for fever of unknown origin

Chapter 26. Exploring the overall effects of two traditional Chinese medicines on the body by urinary proteome

Chapter 27. Effects of extrinsic factors on the urinary proteome

Chapter 28. Take a deep breath

Chapter 29. Tears: Potential Window for Monitoring Systemic Conditions

Chapter 30. Changes of urine protiens in the rat e-cigarette model

Chapter 31. Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT).

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Gao, Youhe Urine

ISBN:

9789819678860

OCLC:

1527722220