Autophagy - From Molecular Mechanisms to Flux Control in Health and Disease / edited by Ben Loos, Daniel J. Klionsky.

Format:

Book

Author/Creator:

Loos, Ben.

Contributor:

Klionsky, Daniel J.

Series:

Learning Materials in Biosciences, 2509-6133

Language:

English

Subjects (All):

Cytology.

Aging.

Biochemistry.

Metabolism.

Neurosciences.

Cancer.

Cell Biology.

Cellular Senescence.

Metabolic Pathways.

Neuroscience.

Cancer Biology.

Local Subjects:

Cell Biology.

Cellular Senescence.

Metabolic Pathways.

Neuroscience.

Cancer Biology.

Physical Description:

1 online resource (446 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

This textbook describes the autophagy pathway with all its key molecular mechanisms and its physiological functions from yeast to eukaryotes in a didactic and reader-friendly manner. It provides the most critical aspects that need to be understood to foster research and clinical translation in this area. Autophagy activity, mechanism and control in the context of cellular fate are central to this book, underpinned by human pathologies of priority. Further, key chapters describing major techniques required to assess autophagy activity, and highlighting starting points for the research of potential drug candidates and clinical translation, offer detailed insight into practice and application. The work represents a comprehensive study guide that allows undergraduate and postgraduate students in biology and biomedicine to rapidly engage with the most critical and recent aspects of autophagy in health and its control of disease. Written in a style that may be favourable for its use in the classroom, this book can also serve as a valuable source for teaching in the biomedical and medical sciences.

Contents:

Chapter 1. How to Learn, and Teach, Autophagy

Chapter 2. Discerning autophagy pathway intermediates – transmission electron microscopy techniques

Chapter 3. Assessment of Autophagy: Correlative and Super-Resolution Microscopy Techniques

Chapter 4. Autophagy receptors couple cargo destined to be degraded with the core autophagy machinery

Chapter 5. The source of membrane during autophagy and the early steps in autophagosome formation

Chapter 6. Autophagy and neurodegenerative diseases

Chapter 7. Autophagy and intracellular membrane dynamics in aging and age-related diseases

Chapter 8. Shear stress-dependent regulation of autophagy and metabolism in kidney epithelial cells

Chapter 9. Autophagy assessment in diagnostic pathology: Focus on skeletal myopathies

Chapter 10. The role of autophagy and mitophagy in cardiomyocyte ischemic injury

Chapter 11. Chaperone-mediated autophagy in health and disease

Chapter 12. A phenotypic screening routine for the identification of autophagic flux inducers.

ISBN:

3-031-88121-4

OCLC:

1528960736