Translational Neuroscience : Fundamental Approaches for Neurological Disorders / edited by Mark H. Tuszynski.

Format:

Book

Author/Creator:

Tuszynski, Mark H.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Neuroscience.

Translational Research.

Local Subjects:

Neuroscience.

Neurology.

Translational Research.

Physical Description:

1 online resource (0 pages)

Edition:

2nd ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

The second edition of Translational Neuroscience offers wide-ranging and insightful perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, rehabilitation, and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides detailed coverage of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. All of the first edition chapters have been extensively updated, and many new chapters have been added, including brain-machine interface, gene therapy, anti-sense oligonucleotides, and CRISPR. Among the many other topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation, and clinical trial design/consideration.

Contents:

I Introduction II Molecular Therapies

Gene Therapy, Anti-Sense Oligonucleotides, RNA Interference, and CRISPR

Gene Therapy Tools for Translational Neuroscience

AAV9 SMN1 Gene Therapy for Spinal Muscular Atrophy

Gene Therapy for Retinitis Pigmentosa

NGF and BDNF Gene Therapy for Alzheimer’s Disease

Proganulin Gene Therapy in Alzheimer’s Disease

AADC Gene Therapy for Congenital Dopamine Deficiency

Gene Therapy for Inborn Errors of Metabolism

GDNF Gene Therapy forParkinson’s Disease

GDNF Gene Therapy for Parkinson’s Disease

Gene Therapy for Spinal Cord Injury

GAD Gene Therapy for Epilepsy

Gene Therapy for Pain

Anti-Sense Oligonucleotide Gene Therapy for Huntington’s Disease

Anti-Sense Oligonucleotide Gene Therapy for Spinocerebellar Ataxia

Anti-Sense Oligonucleotides for Amyotrophic Lateral Sclerosis

Micro-RNA Gene Therapy for Huntington’s Disease

Targeting C9orf72 Mutations in Frontotemporal Dementia

CRISPR-Cas9 Therapy for Alzheimer’s Disease III Stem Cells

Stem Cells for Amyotrophic Lateral Sclerosis

iPSCs for Parkinson’s disease

Stem Cells for Huntington’s disease

Stem Cells for Multiple Sclerosis

Stem Cells for Inborn Errors of Metabolism

Stem Cells for Spinal Cord Injury

Induced Pluripotent Stem Cells for Retinal Disease

Bone Marrow Stromal Cells for Stroke

Glioma Stem Cells

IV Pharmacological Approaches to Neural Therapy

Amyloid-Modulating Therapies for Alzheimers Disease

Novel Pharmacological Therapies for Alzheimer’s Disease

Down’s Syndrome

Spinal Cord Injury

Nogo Inhibition in SCI

Intrinsic Neuronal Mechanisms in Spinal Cord Injury

Translational Neuroscience and Pain

Neurodevelopmental Disorders and Autism

V Activity Dependent Plasticity and Neurorehabilitation

Epidural Spinal Stimulation for Spinal Cord Injury

Neural Prostheses for Neurotrauma

Neuroengineering in Rehabilitation

Deep Brain Stimulation for Neuropsychiatric Disorders

Brain Machine Interface for Spinal Cord Injury

Pharmacological Approaches to Enhance Stroke Recovery

VI Conclusion.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Tuszynski, Mark H. Translational Neuroscience

ISBN:

9783031893070

OCLC:

1526863592