Biomarkers of Neurodegenerative Disorders : Current Progress and Future Directions / edited by Rawan Tarawneh.

Format:

Book

Author/Creator:

Tarawneh, Rawan.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Neurosciences.

Diagnosis.

Neurology.

Neuropharmacology.

Neuroscience.

Local Subjects:

Neuroscience.

Diagnosis.

Neurology.

Neuropharmacology.

Physical Description:

1 online resource (932 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

This book presents state-of-the-art knowledge regarding fluid and imaging biomarkers of neurodegenerative disorders, including Alzheimer disease and related dementias (ADRD). A cadre of the top experts in the field discuss the diagnostic and prognostic value of established and emerging biomarkers in ADRD, their ability to track or monitor disease progression or predict cognitive outcomes, and their potential as novel therapeutic targets. Biomarkers are discussed both in the context of specific disease mechanisms, including amyloid, tau, and synuclein pathologies, endothelial, vascular, neuronal, and synaptic injury, and glial reactivity as well as a wide spectrum of neurodegenerative disorders that encompass various pathologies. Multi-omics approaches in ADRD biomarker and drug target discovery including proteomics, genomics, and transcriptomics are covered. Importantly, the authors highlight the need to integrate biomarkers into various stages of ADRD drug development to accelerate drug discovery and approval. The book provides in-depth insight regarding significant progress in ADRD biomarker research over the last decade, addresses potential challenges in the translation of ADRD biomarkers into the clinic, and proposes important directions for future research.

Contents:

Section 1: Fluid and Imaging Markers of Pathologies associated with Alzheimer Disease or other Related Dementias

Chapter 1: Fluid and Imaging Markers of Amyloid Pathology

Chapter 2: Fluid Markers of Tau Pathology

Chapter 3: Fluid and Imaging Markers of Synuclein Pathology

Chapter 4: Fluid and Imaging Markers of Synaptic Injury

Chapter 5: Fluid Markers of Neuronal and Axonal Injury

Chapter 6: Fluid and Imaging Markers of Glial Reactivity

Chapter 7: Fluid and Imaging Markers of Vascular Disease

Section 2: Fluid and Imaging Markers of Neurodegenerative Disorders

Chapter 8: Fluid and Imaging Markers of Alzheimer Disease

Chapter 9: Fluid and Imaging Markers of Frontotemporal Lobar Degeneration

Chapter 10: Fluid and Imaging Markers of Lewy body dementias

Chapter 11: Fluid and Imaging Markers of Huntington’s Disease

Section 3: Single and Integrated Omics Studies in Biomarker Discovery

Chapter 12: Proteomics for Novel Biomarker and Drug Target Discovery in Alzheimer Disease

Chapter 13: Genomics and Transcriptomics of Alzheimer Disease

Section 4: Biomarkers in Clinical and Translational Alzheimer Disease Research

Chapter 14: Biomarkers in Clinical Trials of Alzheimer Disease: An Overview

Chapter 15: Biomarkers As Outcome Measures in Clinical Trials of Alzheimer Disease

Chapter 16: Impact of Pre-analytical Factors on Fluid Biomarker Measurements in Alzheimer Disease

Chapter 17: Mild Behavioral Impairment and Alzheimer’s Disease Biomarker Sample Enrichment for Clinical Trial Screening and Recruitment

Section 5: Future Directions in Biomarker Research

Chapter 18: Extracellular Vesicles as Biomarkers in Alzheimer Disease and Related Dementias

Chapter 19: Sex Differences in Alzheimer Disease-Related Biomarkers and Dementia Risk

Chapter 20: Imaging Markers of Amyloid and Tau

Chapter 21: Novel Markers of Brain Endothelial Injury

Epilogue: Expert Commentary on Future Directions or Epilogue: Sex/racial differences, standardization, and TDP-43.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Tarawneh, Rawan Biomarkers of Neurodegenerative Disorders

ISBN:

9783031808494

OCLC:

1526859212