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Handbook of Proteolytic Enzymes : Metallopeptidases.
Elsevier ScienceDirect eBook - Biochemistry, Genetics and Molecular Biology 2025 Available online
View online- Format:
- Book
- Author/Creator:
- Rawlings, Neil D.
- Series:
- Handbook of Proteolytic Enzymes, Two-Volume Set with CD-ROM Series
- Language:
- English
- Physical Description:
- 1 online resource (5850 pages)
- Edition:
- 4th ed.
- Place of Publication:
- Chantilly : Elsevier Science & Technology, 2025.
- Summary:
- Handbook of Proteolytic Enzymes, Metallopeptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998.
- Contents:
- 9780443288500v1
- Front Cover
- Handbook of Proteolytic Enzymes
- Copyright Page
- Contents
- List of contributors
- Preface
- Abbreviations
- Introduction
- Terminology
- Organization of the Handbook
- Special forms of information in the Handbook
- Links to the MEROPS database
- Molecular images
- Alignments
- Secondary structure
- Description of substrate specificity
- References
- 1 Introduction: metallopeptidases and their clans
- Metallopeptidases with a single catalytic metal ion
- Clan MA
- Subclan MA(E)
- Subclan MA(M)
- Asp-zincins
- Clan MM
- Clan MW
- Clan MU
- Clan MC
- Clan MD
- Clan ME
- Clan MO
- Clan MP
- Metallopeptidases with cocatalytic metal ions
- Clan MF
- Clan MG
- Clan MH
- Clan MJ
- Clan MN
- Clan MQ
- Other families of metallopeptidases
- 2 Catalytic mechanisms for metallopeptidases
- Metal sites in metalloproteases
- Catalytic sites
- Structural sites
- Cocatalytic sites
- Scaffolding of the sites
- Mechanisms of metalloproteases containing catalytic zinc sites
- Catalytic 2His1Glu/Asp zinc sites
- Alternative mechanisms
- Catalytic 3His zinc sites
- Additional active site participants
- Mechanisms of metalloproteases containing cocatalytic metal sites
- Bovine lens leucine aminopeptidases
- Aeromonas proteolytica aminopeptidase
- Methionine and proline aminopeptidases
- Additional reading
- 3 Aminopeptidase N
- Databanks
- Name and history
- Activity and specificity
- Structural chemistry
- Preparation
- Biological aspects
- Distinguishing features
- Related peptidases
- Further reading
- 4 Glutamyl aminopeptidase
- Acknowledgments
- Further reading.
- References
- 5 Cystinyl aminopeptidase (oxytocinase)
- 6 Aminopeptidase Q
- 7 Pyroglutamyl-peptidase II
- 8 Aminopeptidase ERAP-1
- 9 Endoplasmic reticulum aminopeptidase 2
- Gene and protein structure
- Enzyme preparation
- Related peptidases and distinguishing features
- Biological aspects: tissue distribution
- Biological aspects: antigen processing
- Biological aspects: autoimmune diseases
- Biological aspects: infection, cancer and preeclampsia
- 10 Leukotriene A4 hydrolase
- 11 Tripeptide aminopeptidase
- 12 Cytosol alanyl aminopeptidase
- Distinguishing features.
- Further reading
- 13 Aminopeptidase B
- Biological sources
- Expression systems
- Further readings
- 14 Aminopeptidase Ey
- 15 Insect aminopeptidase N
- Source
- Isolation and purification
- 16 Aminopeptidase H11 (nematode)
- 17 Yeast aminopeptidases Ape2, Aap1′, and TMA108
- 18 Leukotriene A4 hydrolase (Saccharomyces cerevisiae)
- 19 PfA-M1 aminopeptidase (Plasmodium falciparum)
- Catalysis
- Inhibition
- Hemoglobin catabolism
- Additional functions
- Cross-references
- 20 Lysyl aminopeptidase (bacteria)
- Activity and specificity.
- Structural chemistry
- 21 Alanyl aminopeptidase (bacterial-type)
- Glossary
- Nomenclature
- Mutational studies
- 22 Aminopeptidase N (Streptomyces lividans)
- Structural chemistry and preparation
- 23 The cold-active M1 aminopeptidase from the Arctic bacterium Colwellia psychrerythraea
- Aminopeptidase activity
- Cold-adapted activity
- Gene sequence and homology
- Conformational stability
- Crystal structure
- Structural determinants of cold adaptation
- Zinc-binding site
- Aminopeptidase active site
- Epoxide hydrolase active site
- 24 Tricorn interacting factors F2 and F3
- 25 Peptidyl-dipeptidase A/angiotensin I-converting enzyme
- Reaction and specificity
- Angiotensin I-converting enzyme functions: new aspects
- Assay methods
- Inhibitors
- Primary structure
- Tertiary structure
- Physical properties
- Sources of angiotensin I-converting enzyme protein
- Isolation and purification of angiotensin I-converting enzyme
- Gene structure.
- Mechanism of angiotensin I-converting enzyme anchorage and solubilization
- Angiotensin I-converting enzyme immunochemistry to detect conformational changes
- Tissue distribution
- Genetic control of angiotensin I-converting enzyme
- Altered angiotensin I-converting enzyme expression in diseases
- Glossary entries
- 26 Angiotensin-converting enzyme-2
- Synopsis
- 27 Peptidyl-dipeptidase A (invertebrate)
- 28 Thimet oligopeptidase
- 29 Neurolysin
- Acknowledgment
- 30 Saccharolysin
- 31 Mitochondrial intermediate peptidase
- Biological properties
- Related enzymes
- 32 Oligopeptidase MepB
- Biological aspects.
- Distinguishing features.
- Notes:
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-443-28850-X
- OCLC:
- 1527723878
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