Coffee and Human Health : Chemistry and Mechanisms of Action.

Format:

Book

Author/Creator:

Grosso, Giuseppe.

Series:

Issn Series

Issn Series ; v.Volume 45

Language:

English

Subjects (All):

Coffee.

Bioactive compounds.

Physical Description:

1 online resource (431 pages)

Edition:

1st ed.

Place of Publication:

Cambridge : Royal Society of Chemistry, The, 2025.

Summary:

Written by renowned researchers in the field, this title provides an updated overview of existing evidence for the good and bad health effects of coffee consumption.

Contents:

Cover

Copyright

Preface

Contents

Chapter 1 Introduction to Coffee History, Preparation Methods, and the Basic Chemistry of Its Bioactive Compounds

1.1 Introduction

1.2 History of Coffee

1.3 Coffee Market and Consumption

1.4 Coffee Types, Processing, and Preparation Methods

1.5 Coffee Bean Components: A Magic Bullet for Health?

1.5.1 Caffeine

1.5.2 Chlorogenic Acids

1.5.3 Diterpenes

1.5.4 Melanoidins

1.5.5 Trigonelline

1.6 Conclusions

References

Chapter 2 Coffee Preparations and Roasting

2.1 Introduction

2.2 Effect of Preparations on Coffee Quality

2.2.1 Effect of Fermentation

2.2.2 Effect of Steam Treatment

2.2.3 Effect of Decaffeination

2.2.4 Effects of Other Preparations

2.3 Effect of Roasting on Coffee Quality

2.4 Conclusions

Acknowledgments

Chapter 3 Recent Trends in Spent Coffee Grounds: Phytochemical Profiling and Valorization Opportunities

3.1 Introduction

3.2 Spent Coffee Grounds' Chemical Profiling and Antioxidant Capacity

3.2.1 Antioxidant Compounds

3.2.2 Mineral Composition

3.2.3 Proteins

3.2.4 Spent Coffee Ground Oil

3.2.5 Sterol Composition

3.2.6 Fatty Acid Profile

3.3 Spent Coffee Ground Valorization

3.4 Conclusion

Chapter 4 Caffeine

4.1 Introduction

4.1.1 Caffeine - Resources, Concentrations, and Techniques

4.1.2 Caffeine - Pharmacokinetics

4.2 Biological Effects of Caffeine

4.2.1 Caffeine - Cardiovascular System and Its Components

4.2.2 Caffeine - Adipose Tissue

4.2.3 Caffeine - Skeletal Muscle Tissue

4.2.4 Caffeine - Central Nervous System (CNS)

4.3 Conclusions

Author Contributions

Chapter 5 Cafestol and Kahweol

5.1 Introduction

5.2 Chemistry of Cafestol and Kahweol

5.3 Biosynthesis.

5.4 Composition of Coffee Diterpenes in Nature

5.4.1 Inter-species Differentiation

5.4.2 Intra-species Differentiation

5.4.3 Diterpenes in Seed and Non-seed Parts

5.4.4 Biological and Ecological Roles in Plants

5.4.5 Extraction and Isolation from Green Coffee Beans

5.5 Instrumental Analysis for Identification and Quantification

5.6 Coffee Roasting and Its Degradation Products

5.7 Content in Coffee Beverages

5.7.1 Extraction Parameters in Coffee Brewing

5.7.2 Brew Quality

5.8 Biological Activities

5.9 Absorption, Metabolism, and Excretion

5.10 Conclusions

Chapter 6 The Main Coffee Polyphenols: Chlorogenic, Ferulic, and Caffeic Acids

6.1 Introduction

6.2 Structure of Chlorogenic Acid

6.3 Source of Chlorogenic Acid

6.4 Absorption and Blood Transfer of Chlorogenic Acid

6.5 Health Benefits of Chlorogenic Acid

6.5.1 Effects of Chlorogenic Acid on T2DM

6.5.2 Effects of Chlorogenic Acid on Diabetic Complications

6.5.3 Effects of Chlorogenic Acid on Hypertension

6.5.4 Effects of Chlorogenic Acid on Dyslipidemia

6.6 Health Benefits of Ferulic Acid

6.6.1 Effects of Ferulic Acid on T2DM

6.6.2 Effects of Ferulic Acid on Diabetic Complications

6.6.3 Effects of Ferulic Acid on Hypertension

6.6.4 Effects of Ferulic Acid on Dyslipidemia

6.7 Health Benefits of Caffeic Acids

6.7.1 Effects of Caffeic Acids on T2DM

6.7.2 Effects of Caffeic Acids on Diabetic Complications

6.7.3 Effects of Caffeic Acids on Hypertension

6.7.4 Effects of Caffeic Acids on Dyslipidemia

6.8 Conclusion

Abbreviations

Chapter 7 Coffee Melanoidins and Gut Health

7.1 Introduction

7.2 Chemistry of Coffee Melanoidins

7.2.1 Chemical Routes of Melanoidin Formation

7.3 Coffee Melanoidins in the Gastrointestinal Tract.

7.3.1 Coffee Melanoidins and Enzyme Activity

7.3.2 Coffee Melanoidins and Antioxidant Activity

7.3.3 Coffee Melanoidins and Gut Microbiota

7.4 Conclusions

Chapter 8 Coffee, the Metabolome and the Gut Microbiome

8.1 Introduction

8.1.1 The Metabolome

8.1.2 Microbiota and Microbiome

8.2 Coffee-related Metabolome

8.3 Effects of Coffee Consumption on Gut Microbiota

8.4 Conclusions

Chapter 9 Coffee and Oxidative Stress

9.1 Introduction

9.2 Oxidative Stress and Health

9.3 Inflammation and Health

9.4 Oxidative Stress and Coffee Consumption

9.5 Inflammation and Coffee Consumption

9.6 Conclusion

Chapter 10 Coffee and Cardiovascular Disease

10.1 Introduction

10.2 Coffee and Arterial Hypertension

10.2.1 Mechanisms

10.2.2 Coffee and Risk of Hypertension

10.2.3 Coffee and Blood Pressure Control in Patients with Arterial Hypertension

10.2.4 Coffee Consumption Through the Prism of Clinical Guidelines and Recommendations

10.2.5 Summary and Practical Conclusions

10.3 Coffee and Lipid Disorders

10.3.1 A Chemical Explanation for the Difference in the Effect of Coffee Consumption on the Lipid Profile

10.3.2 Coffee and Lipids from the Perspective of Guidelines/Recommendations of Scientific Societies

10.3.3 Summary and Practical Conclusions

10.4 Coffee and Heart Diseases

10.4.1 Coronary Artery Disease

10.4.2 Coffee and the Risk of ACS and Prognosis of Patients After ACS

10.4.3 Coffee and the Risk of Stroke and Prognosis of Stroke Patients

10.4.4 Coffee and the Risk of PAD

10.4.5 Coffee and the Risk of HF

10.4.6 Mechanisms

10.4.7 Summary and Practical Conclusions

10.5 Coffee and Arrhythmias

10.5.1 Results of Clinical Studies

10.5.2 Summary and Practical Conclusions.

10.6 Coffee and Cardiovascular Mortality

10.6.1 Does the Type of Coffee Make a Difference?

10.6.2 Do Coffee Additives Make a Difference?

10.6.3 Filtered or Unfiltered Coffee?

10.6.4 Summary and Practical Conclusions

Chapter 11 Coffee and Metabolic Disorders

11.1 Metabolic Syndrome: Definition and Outcomes

11.2 Coffee and Metabolic Changes

11.2.1 Coffee and Lipid Profile

11.2.2 Coffee and Obesity

11.2.3 Coffee and Metabolic Syndrome

11.3 The Effect of Coffee on Hyperglycemia and Diabetes Mellitus

11.4 Final Comments

Chapter 12 Coffee and Liver Health

12.1 Introduction

12.2 Chronic Liver Diseases

12.2.1 ALD

12.2.2 NAFLD

12.2.3 Liver Fibrosis and Cirrhosis

12.2.4 Liver Cancers

12.3 Clinical and Epidemiological Evidence on Coffee and Liver Health

12.3.1 Coffee Consumption and Markers of Liver Function

12.3.2 Coffee Consumption and Risk of ALD, NAFLD, and Liver Fibrosis

12.3.3 Coffee Consumption and Risk of Liver Cancers

12.4 Mechanisms of Coffee Against Liver Diseases

12.4.1 Coffee and Steatosis

12.4.2 Coffee, Inflammation and Liver Fibrosis

12.4.3 Coffee and Liver Cancers

12.5 Conclusions

Chapter 13 Coffee and Neurodegenerative Diseases

13.1 Introduction

13.2 Coffee Consumption and Dementia

13.3 Coffee Consumption and Parkinson's Disease

13.4 Coffee Consumption and Structural Brain Parameters

13.5 Molecular Mechanisms Underlying the Effects of Coffee and Its Components on the Brain

13.6 Conclusions

Chapter 14 Effects of Caffeine on Kidney Stone Disease and Renal Cancer

14.1 Introduction

14.2 Caffeine in Daily Life and Its Pharmacokinetics

14.3 Caffeine and Kidney Functions

14.4 Roles of Caffeine in Kidney Stone Disease

14.5 Roles of Caffeine in RCC

14.6 Conclusions.

Acknowledgments

Chapter 15 Coffee and Cancer

15.1 Introduction

15.2 Coffee and Digestive Tract Cancers

15.2.1 Oral, Pharyngeal, Laryngeal, and Esophageal Cancers

15.2.2 Gastric Cancer

15.2.3 Colorectal, Colon, and Rectal Cancers

15.3 Pancreatic Cancer

15.4 Liver Cancer and Hepatocellular Carcinoma

15.5 Female Cancers

15.5.1 Breast Cancer

15.5.2 Endometrial Cancer

15.5.3 Ovarian Cancer

15.5.4 Regulation of Sex Hormones' Blood Concentration

15.6 Prostate Cancer

15.7 Lung Cancer

15.8 Bladder Cancer

15.9 Skin Cancers

15.10 Brain Cancers and Glioma

15.11 Blood Cancers

15.12 Mechanisms by Which Coffee May Influence Cancer Risk

15.12.1 Antioxidant Properties

15.12.2 Induction of Endogenous Defense

15.12.3 DNA Methylation

15.12.4 Inhibition of Metastases

15.12.5 Inhibition of Inflammation

15.12.6 Inhibition of Angiogenesis

15.12.7 Moderate Stress Stimulation

15.13 Conclusions

Chapter 16 Coffee Components: Acrylamide, Mycotoxins, and Furan

16.1 Introduction

16.2 Acrylamide

16.3 Furan

16.4 Mycotoxins

16.4.1 Ochratoxins

16.4.2 Other Mycotoxins

16.4.3 Mitigation Strategies

16.5 Conclusions

Chapter 17 Coffee and Osteoporosis and the Risk of Bone Fractures

17.1 Osteoporosis - A Global Health Problem

17.2 Coffee Consumption and Osteoporosis - Potential Biological Mechanisms

17.3 Coffee Consumption and Bone Mineral Density and the Risk of Osteoporosis

17.4 Coffee Consumption and the Risk of Bone Fractures

17.5 Coffee Consumption by People with Osteoporosis - What Do the Guidelines Say?

17.6 Conclusion

Chapter 18 Caffeine and Genetics

18.1 Introduction

18.2 Genetics of Habitual Caffeine Consumption

18.3 Caffeine Pharmacokinetics.

18.3.1 Genetics of Caffeine Absorption and Distribution.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

1-83916-686-X

1-83916-685-1

OCLC:

1517976260