Modelling the short QT syndrome gene mutations and their role in cardiac arrhythmogenesis Ismail Adeniran

Format:

Book

Author/Creator:

Adeniran, Ismail, author.

Series:

Springer theses

Language:

English

Subjects (All):

Heart--Ventricles--Diseases.

Heart.

Heart--Ventricles--Abnormalities.

Physics.

Cardiology.

Cell Membrane.

Systems Biology.

physics.

Medical Subjects:

Physics.

Cardiology.

Cell Membrane.

Systems Biology.

Physical Description:

1 online resource

Place of Publication:

Cham Springer [2014]

Language Note:

English

Summary:

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as 'outstanding.'

Contents:

Ion Channels and the Action Potential

Potassium Channels Implicated in the Short QT Syndrome

The Short QT Syndrome

Model Development

Methods, Experimental Protocols and Mathematical Preliminaries

Increased Vulnerability of the Human Ventricle to Re-entrant Excitation in HERG-linked SQT1

Mathematically Modelling the Functional Consequences of the SQT2 Mutation

Proarrhythmia in KCNJ2-linked Short QT Syndrome: Insights from Modelling

Relationship between Electrical and Mechanical Systole in the Short QT Syndrome: Insights from Modelling

Discussion and Conclusion

Notes:

Includes bibliographical references

Print version record

UofL: Multi-user access

Other Format:

Print version Adeniran, Ismail. Modelling the short qt syndrome gene mutations

ISBN:

9783319072005

3319072005

OCLC:

881450445

Publisher Number:

(WaSeSS)ssj0001276754

Access Restriction:

Restricted for use by site license