Membrane transport mechanism 3D structure and beyond Reinhard Krämer, Christine Ziegler, editors

Format:

Book

Contributor:

Kramer, Reinhard, editor.

Ziegler, Christine, editor.

Series:

Springer series in biophysics v. 17

Springer Series in Biophysics 0932-2353 17

Language:

English

Subjects (All):

Biological transport.

Carrier proteins.

Biochemistry.

Carrier Proteins.

Biological Transport.

biochemistry.

Medical Subjects:

Carrier Proteins.

Biological Transport.

Biochemistry.

Physical Description:

1 online resource

Place of Publication:

Heidelberg Springer 2014

Summary:

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing number of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture, or, more precisely, a molecular movie. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics

Contents:

Dance Lessons for Proteins: The Dynamics and Thermodynamics of a Sodium/Aspartate Symporter

Characterizing the Structure, Function and Evolution of Human Solute Carrier (SLC) Transporters Using Computational Approaches

Structures of the Prokaryotic Galactose Transporter vSGLT and Their Implications on Alternating Access Mechanism in Human SGLT1

Moving Crystallographic Snapshots: A Mechanism for Transport Regulation in BetP

Development of Refined Homology Models: Adding the Missing Information to the Medically Relevant Neurotransmitter Transporters

The Life and Times of Lac Permease: Crystals Ain't Enough

Alternating Access Within the POT Family of Oligopeptide

Proton Symporters

The Maltose ABC Transporter: Where Structure Meets Function

Cooperative Transport Mechanism and Proton-Coupling in the Multidrug Efflux Transporter Complex ArcAB-TolC

What Can a Living Fossil Tell Us About Evolution and Mechanism of Ion-Coupled Transporters: The Story of Small Multidrug Transporters Symmetrically Asymmetric: EmrE Seen from the NMR Perspective

Notes:

Online resource; title from PDF title page (SpringerLink, viewed March 17, 2014)

Other Format:

Printed edition:

ISBN:

9780191643408

0191643408

9783642538391

3642538398

364253838X

9783642538384

OCLC:

875003166

Access Restriction:

Restricted for use by site license