Biophysics of the failing heart physics and biology of heart muscle R. John Solaro, Jil C. Tardiff, editors

Format:

Book

Contributor:

Solaro, R. John, editor, author.

Tardiff, Jil C., editor, author.

Series:

Biological and medical physics, biomedical engineering 1618-7210

Biological and Medical Physics, Biomedical Engineering 1618-7210

Language:

English

Subjects (All):

Heart--Mechanical properties.

Heart.

Biophysics.

Biomedical engineering.

biomedical engineering.

Physical Description:

1 online resource

Place of Publication:

New York Springer 2013

Language Note:

English

Summary:

Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels

Contents:

Introduction to the Biophysics of the Failing Heart R. John Solaro, Jil C. Tardiff Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure Aleksey V. Zima, Dmitry Terentyev Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes Kathrin Banach Biophysics of Membrane Currents in Heart Failure Man Liu, Vikram Maddikunta Brahmanandam Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function E. Douglas Lewandowski Cytoskeletal Nuclear Links in the Cardiomyocyte Elizabeth McNally Biophysical Forces Modulate the Costamere and Z-Disc for Sarcomere Remodeling in Heart Failure Allen M. Samarel, Yevgeniya Koshman Heart Failure: The Final Frontier for Biophysics in Cardiovascular Medicine? Luis F. Santana Arrhythmogenesis, Heart Failure, and the Biophysics of Z-Band Protein Networks M. Vatta, R. John Solaro Biophysics of Titin in Cardiac Health and Disease Brian R. Anderson, Henk L. Granzier Sarcomeres and the Biophysics of Heart Failure Jillian N. Simon, Jil C. Tardiff

Notes:

Includes index

Online resource; title from PDF title page (SpringerLink, viewed August 20, 2013)

Includes bibliographical references and index

Other Format:

Printed edition:

ISBN:

9781461476788

146147678X

1461476771

9781461476771

OCLC:

857659758

Access Restriction:

Restricted for use by site license