Mathematical modelling of the cell cycle stress response Elahe Radmaneshfar

Format:

Book

Thesis/Dissertation

Author/Creator:

Radmaneshfar, Elahe, author.

Series:

Springer theses 2190-5053

Language:

English

Subjects (All):

Cell cycle--Mathematical models.

Cell cycle.

Genre:

dissertations

Academic theses

Physical Description:

1 online resource

Place of Publication:

Cham Springer 2014

Summary:

The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.? The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks

Contents:

A biological overview of the cell cycle and its response to osmotic stress and the [alpha]-factor

ODE model of the cell cycle response to osmotic stress

Boolean model of the cell cycle response to stress

Conclusion

List of equations, parameters and initial conditions

Effect of methods of update on existence of fixed points

Notes:

Ph. D. University of Aberdeen (2013?)

Includes bibliographical references

Online resource; title from PDF title page (SpringerLink, viewed October 14, 2013)

ISBN:

9783319007441

3319007440

3319007432

9783319007434

1306165539

9781306165532

OCLC:

862151628

Access Restriction:

Restricted for use by site license