The NLRP3 inflammasome : an attentive arbiter of inflammatory response / Puneetpal Singh.

Format:

Book

Author/Creator:

Singh, Puneetpal, author.

Language:

English

Subjects (All):

Immune response.

Inflammation.

Physical Description:

1 online resource (238 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2024]

Summary:

Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer's disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms. This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders. This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals. Readership Researchers, clinicians, and healthcare professionals.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Role of NLRP3 Inflammasome in Airway Inflammation and Fibrosis

Anju Jaiswal1, Asha Kumari2 and Rashmi Singh1,*

INTRODUCTION

INNATE IMMUNE SYSTEM AND PATTERN RECOGNITION RECEPTORS (PPRS)

LPS INDUCED RESPIRATORY DISEASES

LPS Induced Asthmatic Exacerbations

Inflammasome: An Important Aspect of Innate Immune System

Activation Mechanism of the NLRP3 Inflammasome

NLRP3 Inflammasome and Airway Inflammation

Role of NLRP3 Inflammasome in Chronic Airway Inflammation

Airway Fibrosis

Immunomodulation

CURCUMIN AS IMMUNOMODULATORY AGENT

CONCLUDING REMARKS

ACKNOWLEDGEMENT

REFERENCES

NLRP3 Inflammasome: A Novel Mediator in Pulmonary Hypertension

Sushweta Mahalanobish1, Noyel Ghosh1 and Parames C. Sil1,*

Overview of NLRP3 Inflammasome

Effectors of NLRP3 Inflammasome Activation

Oxidative Stress and Reactive Oxygen Species (ROS)

Lysosomal Activity Generated by AI.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

ISBN:

9789815223941

9815223941

OCLC:

1432590917