Methods for Laboratory Studies : (Focusing Area : Natural Product Drug Discovery) / Torequl Islam.

Format:

Book

Author/Creator:

Islam, Torequl, author.

Series:

Research advances in communication studies.

Research Advances in Communication Studies

Language:

English

Subjects (All):

Drug development.

Drugs--Research--Methodology.

Drugs.

Physical Description:

1 online resource (392 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"In the dynamic field of drug discovery and development, non-clinical and pre-clinical studies are the foundation of success. With global relevance, "Methods for Laboratory Studies" is your comprehensive guide, offering vital insights for researchers, educators, and students worldwide. The book begins by highlighting the crucial role of non-clinical studies, conducted with strict adherence to Good Laboratory Practice (GLP) regulations. From experimental animals to diverse therapeutic goals, it ensures the highest safety and compliance standards. Dive deeper into early pre-clinical studies, the compass for Go/No-Go decisions. Here, you'll uncover the core elements of a new drug's journey, from pharmacokinetics to safety profiles, including toxicogenetics. Emphasizing GLP-compliant studies, like repeated dosage toxicity, genotoxicity, and safety pharmacology, it guarantees safe human exposure before human trials. Before entering human trials, meticulous completion of non-clinical and pre-clinical studies establishes a robust foundation for Investigational New Drug (IND) applications. Gain insights into the comprehensive research data package bridging the gap between animal and human trials as you turn the pages. After IND approval, additional GLP tests assess carcinogenicity, genotoxicity, chronic toxicity, and reproductive and developmental toxicity. "Methods for Laboratory Studies" isn't just a textbook; it's your gateway to mastering drug discovery. Whether you're a student, educator, or seasoned researcher, this book provides lucid, essential guidelines, empowering you to shape the future of pharmaceutical science"-- Provided by publisher.

Contents:

Natural product drug discovery

Introduction to non-clinical and pre-clinical studies

Collection and extraction of materials

Isolation of lead compounds

Management of experimental animals

Acute toxicity study and dose determination

Administration route selection

Nanotechnology : the interaction of metal ions with extract

Biological activity studies

Biopharmaceutical studies

Toxicity analysis

Computer-aided drug design (in silico study)

Reagent preparation.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Islam, Torequl Methods for Laboratory Studies (Focusing Area: Natural Product Drug Discovery)

ISBN:

9798891133389

OCLC:

1415896502