Phytochemicals as an epigenetic modifier in cancer prevention / edited by Nidhi Puranik, Deepa Yadav, and Sangeeta Shukla.

Format:

Book

Contributor:

Puranik, Nidhi, editor.

Yadav, Deepa, editor.

Shukla, Sangeeta, editor.

Series:

IOP Ebooks Series

Language:

English

Subjects (All):

Cancer--Prevention.

Cancer.

Phytochemicals--Therapeutic use.

Phytochemicals.

Physical Description:

1 online resource (360 pages)

Edition:

First edition.

Place of Publication:

Bristol, England : IOP Publishing, [2023]

Summary:

Phytochemical-based cancer therapeutics by targeting epigenetic and cell signalling.

Contents:

Intro

Acknowledgments

Editor biographies

Dr Nidhi Puranik

Dr Deepa Yadav

Professor (Dr) Sangeeta Shukla

List of contributors

Chapter Phytochemicals and cancer: an overview

1.1 Introduction

1.2 Hallmarks of cancer

1.3 Phytochemicals and cancer

1.3.1 Polyphenols

1.3.2 Alkaloids

1.3.3 Terpenoids

1.3.4 Organosulfur compounds (OSCs)

1.3.5 Nitrogen-containing compounds

1.4 Different mechanism of phytochemicals as an anti-cancerous agent

1.4.1 Anti-oxidants

1.4.2 Cell cycle inhibition

1.4.3 Autophagy

1.4.4 Necrosis and apoptosis

1.4.5 Epigenetic regulator

1.4.6 Anti-mutagenic

1.4.7 miRNA regulation

1.5 Purification of anti-cancer phytochemicals

1.6 Conclusion and future prospective

References

Chapter Vitamins: an emerging natural therapeutic drug to prevent cancer

2.1 Introduction

2.2 Vitamins

2.3 Vitamins and cancer

2.3.1 Vitamin A and cancer

2.3.2 Vitamin B complex and cancer

2.3.3 Vitamin C and cancer

2.3.4 Vitamin D and cancer

2.3.5 Vitamin E and cancer

2.3.6 Vitamin K and cancer

2.4 Conclusion and future prospective

Chapter Phytochemicals as an epigenetic modifier to prevent cancer

Abbreviations

3.1 Introduction

3.2 Epigenetics

3.2.1 DNA methylation

3.2.2 Histone modification

3.2.3 Non-coding RNAs

3.3 Oxidative stress and epigenetics

3.4 Phytochemicals

3.4.1 Polyphenols

3.4.2 Alkaloids

3.4.3 Terpenoids

3.4.4 Organosulfur compounds

3.5 Concluding remark and future prospective

Chapter Role of dietary natural food as a therapeutic drug to prevent lung cancer

4.1 Introduction

4.2 Epigallocatechin gallate

4.2.1 Structure

4.2.2 Function

4.3 Isothiocyanates

4.3.1 Structure

4.3.2 Function

4.4 Indole-3-carbinol.

4.4.1 Structure

4.4.2 Function

4.5 Genistein

4.5.1 Structure

4.5.2 Function

4.6 Curcumin

4.6.1 Structure

4.6.2 Function

4.7 Polyphenol from pomegranate

4.7.1 Structure

4.7.2 Function

4.8 Fisetin

4.8.1 Structure

4.8.2 Function

4.9 α-Carotene

4.9.1 Structure

4.9.2 Function

4.10 β-Carotene

4.10.1 Structure

4.10.2 Function

4.11 Lycopene

4.11.1 Structure

4.11.2 Function

4.12 Lutein

4.12.1 Structure

4.12.2 Function

4.13 β-Cryptoxanthin

4.13.1 Structure

4.13.2 Function

4.14 Astaxanthin

4.14.1 Structure

4.14.2 Function

4.15 Canthaxanthin

4.15.1 Structure

4.15.2 Function

4.16 Fucoxanthin

4.16.1 Structure

4.16.2 Function

4.17 Probiotics

4.17.1 Structure

4.17.2 Function

4.18 Carvone

4.18.1 Structure

4.18.2 Function

4.19 Alliin

4.19.1 Structure

4.19.2 Function

4.20 Shogaol

4.20.1 Structure

4.20.2 Function

4.21 Carnosic acid and rosmarinic acid

4.21.1 Structure

4.21.2 Function

4.22 Omega-3

4.22.1 Structure

4.22.2 Function

4.23 Vitamin A

4.23.1 Structure

4.23.2 Function

4.24 Vitamin B

4.24.1 Structure

4.24.2 Function

4.25 Vitamin D

4.25.1 Structure

4.25.2 Function

4.26 Vitamin E

4.26.1 Structure

4.26.2 Function

4.27 Vitamin C

4.27.1 Structure

4.27.2 Function

4.28 Micronutrients

4.29 Summary

Chapter Polyphenols and their metabolites: a molecular regulator at the epigenetic level in cancer protection

5.1 Introduction

5.2 Polyphenols and their metabolites

5.3 Chemical structure of four classes of polyphenols

5.4 Food sources of polyphenols:

5.5 Medicinal properties of polyphenols

5.5.1 Polyphenols as a neurodegenerative modulatory agent

5.6 Anticancer properties of polyphenols.

5.7 Epigenetic regulation of gene expression

5.7.1 DNA methylation mechanism

5.7.2 Histone modification

5.7.3 Non-coding RNA

5.8 Epigenetic modifications by polyphenols

5.9 Conclusion

Chapter Potential role of nutritional factors in lung cancer prevention and management

6.1 Introduction

6.2 Malnutrition in patients with lung cancer

6.3 Nutrient's role in lung cancer treatment

6.3.1 Role of probiotics/prebiotics in lung cancer

6.3.2 Role of vitamins and minerals in lung cancer

6.3.3 Role of protein and amino acids in lung cancer

6.3.4 Role of polyunsaturated fatty acids enriched diets in lung cancer

6.3.5 Role of fibers-enriched diet in lung cancer

6.3.6 Anti-inflammatory and antioxidant in lung cancer

6.4 Physical activity and lung cancer prevention

6.5 Conclusion

Chapter Plant flavonoids and cancer chemoprevention: their role in epigenetic regulations

7.1 Introduction

7.2 Epigenetics of cancer

7.3 Epigenetics modulators: Flavonoids

7.3.1 Dietary flavonoids

7.3.2 Hormetic effects of dietary flavonoids

7.3.3 Damage of cellular DNA

7.4 Anticancerous agent: plant flavonoids

7.5 Current challenges

7.6 Conclusion and future prospects

Chapter Targeting foremost molecular signaling pathways regulating tumor development with phytochemicals

8.1 Introduction

8.2 Molecular signaling pathways and cancer

8.2.1 Fibroblast growth factor and receptor (FGFRs)

8.2.2 Notch signaling

8.2.3 The wingless-type (Wnt)/β-catenin signaling

8.2.4 BCL-2 family

8.2.5 Receptor tyrosine kinase family

8.2.6 Foxo family

8.2.7 PI3K/AKT/mTOR pathway

8.2.8 CDK and CDK pathway

8.2.9 TLR4 signaling pathway

8.3 Reactive oxygen species and cancer

8.4 Phytochemicals.

8.5 Phytochemicals-based regulation of cancer signaling pathway

8.5.1 Polyphenol

8.5.2 Alkaloids

8.5.3 Terpenoids

8.5.4 Organosulfur compound

8.5.5 Nitrogen-containing compounds

8.6 Conclusion and future prospective

Chapter Natural phytochemicals as anti-cancer agents: from past to present scenario

9.1 Introduction

9.2 Cancer treatment drugs and their limitations

9.3 Plants and their medicinal properties

9.3.1 History of plants as anti-cancer agents

9.3.2 Current contribution of phytochemicals in cancer treatment

9.3.3 Future possibilities of phytochemicals in cancer treatment

9.4 Discussion

9.5 Conclusion

Chapter An overview of phytochemicals under clinical trials for various cancers

10.1 Introduction

10.2 Herbal plants and their role in cancer prevention

10.2.1 Garlic (Allium sativum)

10.2.2 Camptotheca acuminata

10.2.3 Curcumin

10.2.4 Hibiscus sabdariffa

10.2.5 Viola tricolor

10.2.6 Resveratrol

10.2.7 Green tea

10.2.8 Panax ginseng

10.2.9 Rhus verniciflua

10.2.10 Viscum album

10.2.11 Isoflavones

10.2.12 Isothiocyanates

10.2.13 (−)-Epigallocatechin-3-gallate (EGCG)

10.2.14 Capsaicin

10.2.15 Lycopene

10.2.16 Piperlongumine

10.2.17 Podophyllotoxins

10.2.18 Cabazitaxel

10.2.19 Genistein

10.3 Conclusion

Chapter Screening of possible anti-cancer phytochemicals against cancer by structure-based docking studies

11.1 Introduction

11.2 Mechanism of cancer

11.2.1 Classification of cancer

11.2.2 Causes of cancer

11.2.3 P53 gene and protein

11.2.4 EGFR

11.2.5 COX proteins

11.2.6 JAK/STATs signaling pathways

11.3 Methodology

11.3.1 Ligand preparation

11.3.2 Preparation of protein structure

11.3.3 Active site prediction.

11.3.4 Docking studies

11.4 Pharmacological potential of phytochemicals

11.5 Physicochemical/pharmacokinetics properties of phytochemicals

11.6 Docking analysis

11.7 Docking results and discussion

11.7.1 EGFR-HER2/3 and VEGFR

11.7.2 GLUT 4

11.7.3 NF-κβ

11.7.4 BRCA2, estrogen and progesterone receptor

11.7.5 Cyclin-dependent kinase (CDK)

11.7.6 P53-MDM2 pathway

11.7.7 COX inhibition

11.7.8 Tyrosine kinases and human topoisomerase

11.8 Conclusion

Chapter Modern approaches to study the effects of phytochemicals on cellular epigenome

12.1 Introduction

12.2 Methods in epigenome profiling

12.2.1 Direct methods

12.2.2 Indirect methods

12.2.3 Integrative approach

12.3 Conclusion

Chapter Advancement in phytochemical delivery systems for improved anti-cancer activity

13.1 Introduction

13.2 Mechanism of action of phytochemicals

13.2.1 Effects of detoxifying carcinogens

13.2.2 Regulation of different cell death pathways

13.2.3 Targeting angiogenesis by phytochemicals

13.2.4 Synergistic effects of phytochemicals in combinations with classical antineoplastic agents

13.3 Delivery systems for enhanced bioavailability of phytochemicals

13.3.1 Solubility

13.3.2 Bioavailability

13.3.3 Stability

13.3.4 Release

13.4 Delivery systems of phytochemicals

13.4.1 Lipid-based delivery systems

13.4.2 Vesicular systems

13.4.3 Liposomes

13.4.4 Transfersomes, ethosomes, phytosomes, and niosomes

13.4.5 Non-vesicular systems

13.4.6 Solid lipid nanoparticles

13.4.7 Nanostructured lipid carriers

13.4.8 Protein-based delivery systems

13.4.9 Systems for delivering carbohydrates

Chapter Potential role of nanophytochemicals in breast cancer therapy

14.1 Introduction

14.2 Breast cancer.

14.2.1 Epidemiology.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9780750352543

075035254X

OCLC:

1417047412