Alternative Remedies and Natural Products for Cancer Therapy : an Integrative Approach / edited by Motamarri Venkata Naga Lalitha Chaitanya, Galvina Pereira, and Heyam Saad Ali.

Format:

Book

Author/Creator:

Chaitanya, Motamarri Venkata Naga Lalitha, Author.

Contributor:

Chaitanya, Motamarri Venkata Naga Lalitha., editor.

Pereira, Galvina, editor.

Ali, Heyam Saad, editor.

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Technological innovations.

Physical Description:

1 online resource (325 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., 2023.

Summary:

This book provides a holistic view of natural products and remedies that have been used to treat cancer. The editors aim to educate readers about the importance of the translational role of natural products in cancer treatment by compiling 14 chapters. The book emphasizes an integrative approach to the topic by blending traditional knowledge that supports alternative therapies with the science of phytochemicals and drug discovery technologies as a means to manage the disease. Key topics include alternative therapies (such as aromatherapy and immune boosting herbal medications), cytotoxic and anti-cancer phytochemicals, drug delivery and discovery technologies (including high-throughput screening) and some drug targets of interest for cancer treatment (such as topoisomerases and caspases). Readers will be able to learn about natural sources of ant-cancer compounds, and the methods used by research and development experts in pharmaceutical and nutraceutical industries to isolate and formulate these compounds. This book will be a handy resource for a wide range of readers. This includes researchers, traditional medical practitioners, PG students, Ph.D. scholars and general readers to understand the role of natural products in cancer treatment. key features ü Explains the importance of alternative therapies in the management of cancer ü Emphasizes the ethnopharmacological approaches to cancer ü Explores natural anticancer drug libraries ü Discusses the role of modern cancer targets and the importance of in-silico tools in anticancer drug discovery ü Addresses modern drug discovery tools and drug delivery technologies concerning their applications in cancer treatment. ü Includes references for further reading Readership Researchers in pharmacology and natural product chemistry; clinicians in oncology and chemotherapy. General readers interested in

anti-cancer medicine.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Clinical Role of Modern Ayurveda in Treating Cancer

Galvina Pereira1,*, Motamarri Venkata Naga Lalitha Chaitanya2 and Rashmi Saxena Pal3

INTRODUCTION

CANCER: AYURVEDIC PERSPECTIVE

Pathophysiology of Cancer as per Ayurveda

Ayurveda in Cancer Treatment

Ayurveda in Post Cancer Therapy

CLINICAL ROLE OF MODERN AYURVEDA

Challenges in Practicing Modern Ayurveda

CONCLUSION

REFERENCES

Aromatherapy: An Adjuvant Treatment in Cancer

Poonam Agrawal1,*

Classification of Aromatherapy

Essential Oil Chemical Composition

Anti-Cancer Mechanism of Action of Essential Oil

Aromatherapy And Cancer Clinical Trials

Anxiety and Aromatherapy

Quality of Life and Aromatherapy

Pain and Aromatherapy

Nausea and Vomiting and Aromatherapy

Sleep Quality and Aromatherapy

Fatigue

Essential Oil Safety

The Traditional Immune Boosting Recipes

Rokeya Sultana1,*

Traditional System of Medicine and its Role in Immunity Boosting

Medicinal Plants Used in Alternative/Traditional Medicines

Common Plants Used as Immunity Boosters Recipies

Commonly used Traditional immune-boosting recipes

The Indian Cytotoxic Weed Flora and Their Phytochemicals

Prabha Thangavelu1,*, Jubie Selvaraj2, Rashmi Saxena Pal3 and Vishnu Nayak Badavath4

Significance of Weeds

Basic Insight into Cancer

Phytochemicals used for cytotoxicity Activity from Weeds

Glimpses of cytotoxic weed plants in India

Acalypha Indica Linn.

Tridax procumbens linn

Leucas aspera (Willd.)linn

Cleome rutidosperma linn

Commelina benghalensis linn

Euphorbia hirta linn

Argemone Mexicana linn.

Adhatoda vasica linn

Calotropis procera linn.

Lantana camara linn

Solanum nigrum linn

Parthenium hysterophorus Linn

Solanum xanthocarpumSchrad. &amp

Wendl.

Scoparia Dulcis linn

Achyranthes aspera linn

Launaeaprocumbens Linn

Heliotropium indicum linn

Ipomoea carnea Jacq

Alternanthera sessilis Linn

Alternanthera philoxeroides (Mart.) Griseb.

Chromolaena odorata linn

Cassia tora Linn

Ageratum conyzoides Linn

Solanum mauritianumScop.

Cestrum aurantiacum Lindl

Cytisus scoparius Linn

Erigeron karvinkianus DC

Phytolacca dodecandraL'Her

Cnicuswallichi DC

Achyranthes bidentataBlume

Artemisia nilagiricalinn

Centella asiatica linn

Berberis vulgaris linn

Declarations

ABBREVIATIONS USED IN THIS CHAPTER

High Throughput Screening Techniques in Anticancer Drug Discovery and Development from Botanicals

Madhavi Patel1,* and Vishal Patel2

PREAMBLE

Cancer and Role of Botanicals - Historical Aspects

Importance of HTS in Anticancer Drug Discovery

HTS Techniques for Anticancer Agents

Anticancer Drug Target Identification

Creating a Botanical Library for HTS Screening

Cell Based HTS Assay

Cell Proliferation/Cell Death Assay

D Cultures

Cell-Based Reporter Assays

Molecular Assays

Analysis of Botanicals for Characterization of Identified Compounds

Assay Miniaturization and Advancement in HTS

Dereplication Techniques: Assistance in Drug Discovery from Botanicals

Merits And Demerits of HTS Screening for Anticancer Agents

Anticancer Phytochemicals of 21st Century: A Multitargeted Approach and Role of Humanism in Oncology

Jubie Selvaraj1,*, Motamarri Venkata Naga Lalitha Chaitanya2, Akey Krishna Swaroop1, Prabha Thangavelu3 and Rashmi Saxena Pal4

INTRODUCTION.

APPROACH TO MULTI-DRUG TARGETING

NETWORK PHARMACOLOGY APPROACHES

CANCER THERAPY THROUGH MULTITARGETING

CORRELATION OF ANTICANCER COMPOUNDS WITH ANTI-INFLAMMATORY, ANTIOXIDANT, ANTIBIOTIC AND ANTIMITOTIC DRUGS

Role of Antioxidants in Cancer Therapy

Role of Anti-inflammatory Agents in Cancer

Antibiotics and Anticancer Compounds

Antimitotics and Anticancer Compounds

CADD IN MULTITARGETED APPROACH

ROLE OF HUMANISM IN ONCOLOGY

Importance of In silico Tools in Anticancer Drug Discovery from Nature

Gnana Ruba Priya Muthaiah1,*, Motamarri Venkata Naga Lalitha Chaitanya2, Seema Sajjan Singh Rathore1, Maida Engels SE4 and Vishnu Nayak Badavath3

Role of Computers in Drug Design

Virtual Screening

Molecular Docking

Structure Based Pharmacophore Mapping

Ligand-Based Drug Discovery

Advantages of 3D Molecular Docking Studies

Ligand-based Pharmacophore

Quantitative Structure-Activity Relationship Modeling

Multiscale De Novo Drug Design

Quantum Chemical Approaches to Structure-Based and Ligand-Based QSAR Models

Using Molecular Dynamics Simulation to Find New Drug Binding Sites

Artificial Intelligence in Anticancer Drug Discovery

Successful Stories of Computational Drug Discovery

Cancer Modeling &amp

Network

Summary

Human Topoisomerases and Caspases: Important Targets in Cancer Therapy

Sandeep Goyal1,*, Mukesh Gangar1,*, Aditya Kulkarni1 and Charu Kamal Yerneni2

DNA TOPOISOMERASES

Classification and Terminology of Topoisomerases

Human topoisomerase I &amp

II

Types of DNA Topoisomerase Inhibitors

Role of Natural Products as Topoisomerase Inhibitors

Topoisomerase I inhibitors

Topoisomerase II inhibitors

CASPASES

Caspase Family

Caspases Structure

Caspases Functions.

Inflammatory Caspases

Apoptotic Caspases

Role of Caspases in Cancer

NATURAL PRODUCTS IN CANCER THERAPY

Cytotoxic Phytochemicals from Mushrooms as Potential Therapeutic Agents

Gana Manjusha Kondepudi1,*, Rashmi Saxena Pal2 and Malakapogu Ravindra Babu2

ANTICANCER METABOLITES IN MUSHROOMS.

Proteins

Alkaloids

Triterpenoids

Polyphenolic Compounds

CLINICAL STATUS OF SOME CYTOTOXIC NOVEL DRUGS LEADS DERIVED FROM MUSHROOMS

Spirulina: A Living Library of Anticancer Phytochemicals

Awotunde Oluwasegun Samson1,*, Omogbadegun Olu Richard1 and Mugambwa Joseph Yusuf 1

Anticancer Properties of Spirulina Platensis

β- Carotene and Polysaccharides

Phycocyanin (Pc)

Terpenoids A Potential Scaffold for Cancer Therapy: A Mechanistic Approach

Surya Kant Tripathi1, Stuti Biswal1, Munmun Panda1 and Bijesh Kumar Biswal1,*

TERPENOIDS

DIFFERENT FORMS OF TERPENOIDS

Monoterpenoids

Diterpenoids

Tetraterpenoids

Sesquiterpenoid

Sesterterpenoids

TERPENOIDS AND CANCER

TERPENOIDS REGULATE CANCER CELL DEATH PATHWAYS

TERPENOIDS REGULATE CELL CYCLE IN CANCER

TERPENOIDS TARGETING CELL SIGNALING PATHWAYS

EGFR signaling Pathway

PI3K/AKT and RAS/RAF/MEK/ERK signaling Pathway

WNT/β-catenin Pathway

STAT3 signaling Pathway

NF-κB signaling Pathway

NOTCH Signaling

SMAD Signaling Pathway

YAP Signaling

TERPENOIDS: ANTI-ANGIOGENIC EFFECTS

TERPENOIDS INHIBIT CANCER CELL MIGRATION, INVASION, AND METASTASIS

TERPENOIDS REGULATING KEY INFLAMMATORY PATHWAYS

Cytotoxic Phytochemical library of RosmarinusOfficinalis

Cannabis in the Treatment of Various Cancers andits Current Global Scenario.

Modern Nanotherapeutic Approaches in TheDelivery of Phyto Pharmceuticals in Anti CancerResearch

Subject Index

Back Cover.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Naga, Motamarri Venkata Alternative Remedies and Natural Products for Cancer Therapy: an Integrative Approach

ISBN:

9789815124699

9815124692

OCLC:

1409028209