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Molecular Medicine and Biomedical Research in the Era of Precision Medicine : New Technologies and Personalized Drug Therapies for Patient Care.
Elsevier ScienceDirect eBook - Biochemistry, Genetics and Molecular Biology 2025 Available online
View online- Format:
- Book
- Author/Creator:
- Sobti, R. C.
- Language:
- English
- Physical Description:
- 1 online resource (1424 pages)
- Edition:
- 1st ed.
- Place of Publication:
- Academic Press [Imprint] March 2025 San Diego : Elsevier Science & Technology Books Saint Louis : Elsevier [Distributor] Saint Louis : Elsevier [Distributor]
- Chantilly : Elsevier Science & Technology, 2025.
- Summary:
- Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.- Investigates the molecular basis and mechanisms of diseases, including cardiovascular, infectious, and neurological diseases- Presents molecular-based therapeutics for personalized treatment and the diagnosis of various conditions- Considers a range of technologies in the field of biomedicine and molecular medicine, including artificial intelligence and nanotechnology
- Contents:
- 9780443223013v1
- Front Cover
- Molecular Medicine and Biomedical Research in the Era of Precision Medicine
- Copyright
- Dedication
- Contents
- Contributors
- About the book
- Preface
- Molecular medicine and biomedical research in the era of precision medicine: New technologies, lifestyle interventions and ...
- Introduction
- The emergence of precision medicine
- Disease subtyping
- Molecular subtyping
- Biomarkers
- Diagnostic biomarkers
- Prognostic biomarkers
- Predictive biomarkers
- Other biomarkers
- Biomarker combinations
- Genomics
- Epigenomics
- Transcriptomics
- Proteomics
- Metabolomics
- Microbiomics and metagenomics
- Proteogenomics and multimodal omics
- Clinically enriched subtypes and deep phenotyping
- Tailored treatment
- Cancer
- Targeted therapy for cancers
- Antibodies
- Small molecules as inhibitors
- Neurodegenerative diseases
- Functional precision medicine
- Other aspects of precision medicine
- Environmental, social and behavioural factors
- Electronic health records
- Digital health
- Big data analytics and AI
- Conclusion
- REFERENCES
- 1 - Molecular medicine for the effective treatment of nonsmall cell lung carcinoma: A clinical and translational ap ...
- NSCLC's proven molecular targets
- EGFR as molecular targets of NSCLC
- Anaplastic lymphoma kinase (ALK) pathway
- Neurotrophic tropomyosin receptor kinase (NTRK)
- ROS-1
- BRAF
- Alternative strategies for improving precision medicine in NSCLC
- NSCLC biomarkers
- Immunohistochemical biomarkers
- Blood and serum based circulating tumour protein biomarkers
- miRNAs-Potential diagnostic biomarkers
- A new kind of drug treatment: Immune checkpoint inhibitors.
- Methodology for treating patients with metastatic NSCLC
- A translational perspective on epigenetic therapy in NSCLC
- References
- 2 - Current development in molecular medicine from diagnosis to treatment
- Challenges in cancer diagnosis and treatment
- Molecular medicine: A tool for diagnosis and treatment of cancer
- Latest biotechnological interventions within the field of molecular medicine
- Exosomal delivery
- Stem cell biology
- CRISPR-Cas9
- Immunotherapy
- RNA interference
- miRNA
- Bioinformatic tools, cancer databases and artificial intelligence
- Deep learning in cancer prognosis or prediction
- Nanotechnology: Nanoparticles in diagnosis and treatment
- 3D cell culture models organoids and spheroids
- Future perspectives
- Abbreviations
- 3 - Single-cell RNA sequencing as a precision medicine approach for complex metabolic disorders
- Single cell transcriptomics and metabolic disorders
- Introduction to single-cell RNA sequencing
- Experimental procedure of high throughput single-cell RNA sequencing
- Sample preparation
- Droplet based method
- Micro- and nano-well based method
- Reverse transcription &
- cDNA amplification
- Library construction and sequencing platforms
- Data analysis and cell annotation (in-silico analysis)
- Advantage of single-cell RNA sequencing over bulk analysis
- Utility of scRNA sequencing in metabolic diseases
- Type II diabetes mellitus
- 4 - miRNAs and the precision revolution: Unleashing personalised medicine in oncology
- MicroRNAs: Biogenesis and mechanisms of action
- MicroRNAs as biomarkers in oncology
- Role of miRNAs as diagnostic biomarkers in cancer
- miRNA-based prognostic markers for cancer outcome prediction
- MicroRNAs and cancer development.
- Circulating miRNAs in cancer
- MicroRNAs in cancer therapy
- Precision medicine in oncology: Challenges and future prospect
- 5 - Nucleic acid based molecular markers in the diagnosis of cancer
- Biomarker
- Molecular marker
- Nucleic acid based markers
- DNA based methods
- Mutations associated with cancer
- Loss of heterozygosity and microsatellite instability
- DNA methylation
- Mitochondrial DNA mutations
- Viral DNA
- RNA based methods
- Telomerase
- Cytokeratin mRNA
- Melanoma antigen gene (MAGE)
- Survivin
- Uroplakins
- Human mammaglobin (hMAM)
- 6 - Impact of pharmacometabolomics in new drug discovery, and development of novel therapies for the management of ...
- Metabolomic technologies
- Pharmacometabolomics
- Noncommunicable diseases
- Cardiovascular diseases
- Metabolomics and cardiovascular disease
- Metabolomics and cancer
- Chronic respiratory diseases
- Metabolomics and chronic obstructive pulmonary disease
- Metabolomics and asthma
- Diabetes
- Diabetes and metabolomics
- Pharmacometabolomics in new drug discovery and development
- Pharmacometabolomics in new drug discovery and development for noncommunicable diseases
- Implication towards cardiovascular disease
- Implication towards cancer
- Implication towards diabetes mellitus
- 7 - Antibiotic resistance and development of alternative therapies
- Brief history and development of antibiotics
- Mechanisms and emergence of antibiotic resistance
- Limiting uptake of drug
- Modification of drug target
- Inactivation of an antimicrobial agent
- Active drug efflux
- Consequence and global impact of antibiotic resistance
- Alternative therapies
- Phage therapy.
- Antimicrobial peptides (AMPs)
- Microbiome therapeutics
- Immunotherapies
- CRISPR-Cas
- Phytochemicals
- Concluding remarks
- 8 - Recent advances and future prospects of adoptive cell-based cancer immunotherapy
- Non-specific cell therapy
- Lymphokine-activated killer (LAK) cell-mediated cell therapy
- Cytokine-induced killer (CIK) cell-mediated cell therapy
- Natural killer (NK) cell based adoptive cell immunotherapy
- Specific immunotherapy
- Adoptive T cell therapy
- Tumour-infiltrating lymphocyte (TIL) therapy
- Endogenous T cell therapy
- Engineered T cell therapy
- CAR-T cell therapy
- Neoantigen-targeted adoptive cell therapy
- EGFRvIII
- Kirsten rat sarcoma virus (KRAS) mutant
- Tn-MUC1
- IDH1 mutant
- Nanoparticle assisted adoptive T cell therapy
- Conclusions
- List of abbreviations
- Conflict of interest
- Acknowledgements
- 9 - Unravelling the impact of NLRP3 inflammasome in fibrosis: Molecular insights into the fibrosis of diverse tissu ...
- NLRP3 inflammasome: An in-depth analysis
- Molecular components of the NLRP3 inflammasome
- Overview of the NLPR3 inflammasome activation
- Lysosomal damage theory
- Reactive oxygen species theory
- The mitochondrial DNA hypotheses
- Molecular mechanism of NLRP3 activation
- Priming and activation of NLRP3
- NLRP3 activation
- Canonical activation of NLRP3
- K+ efflux
- Ca2+ influx
- Cl− efflux
- Lysosomal disruption
- Mitochondrial factors
- Metabolic changes
- Trans-Golgi disassembly
- NLRP3 and pyroptosis
- Regulation by post-translation modifications of NLRP3
- Ubiquitylation
- Phosphorylation
- Sumoylation
- Non-canonical inflammasome activation
- Alternative inflammasome activation.
- Monocytes/macrophages and neutrophils: Role of immune cells in the NLRP3 inflammasome function
- Canonical NLRP3 signalling
- Non-canonical NLRP3 signalling
- Diverse fibrotic disorders and NLRP3
- Cardiac fibrosis
- Lung fibrosis
- Hepatic fibrosis
- Renal fibrosis
- Dermal fibrosis
- Potential therapeutical interventions targeting NLRP3
- Pharmacotherapy options
- NLRP3 inhibitors in early clinical trials
- Current hurdles and future strategies in the NLRP3 therapy
- Future research directions
- Author contribution
- 10 - Unlocking the therapeutic potential of stem cells in lung cancer management: Ushering in a new era of personal ...
- Brief overview of the pathophysiology of lung cancer
- Traditional approaches for lung cancer management
- Focussing on stem cells in lung cancer
- Theories associated with cellular origin
- Key biomarkers involved in cellular detection
- Insights from preclinical studies
- Interplay of immunotherapy and stem cells survival
- Therapeutic potential of plant-derived bioactive compounds
- 11 - Clinical implications of nitric oxide in health and disease: Molecular and cellular mechanisms
- Role of nitric oxide in infectious diseases
- Clinical implications and future prospects of nitric oxide in infectious diseases
- Role of nitric oxide in cancer
- Clinical implications and future prospects of nitric oxide in cancer
- Role of nitric oxide in neurological disorders
- Clinical implications and future prospects of nitric oxide in neurological disorders
- Role of nitric oxide in respiratory diseases
- Exhaled nitric oxide as a diagnostic marker
- Inhaled nitric oxide as therapeutic agent.
- Clinical implications and future prospects of nitric oxide in respiratory disorders.
- Notes:
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-443-22301-7
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