Integral gene drives for malaria control / Nikolai Windbichler.

Format:

Video

Author/Creator:

Windbichler, Nikolai, author.

Language:

English

Subjects (All):

Genetics, Population.

Mosquitoes--Control.

Mosquitoes.

Physical Description:

1 streaming video file (28 min., 49 sec.) : color, sound

Place of Publication:

London : Henry Stewart Talks Ltd, 2025.

System Details:

video file

Contents:

Introduction

Gene drives

Engineered gene drives

What species could gene drive technology be applied to?

Engineered CRISPR/Cas9 gene drives for malaria control

Quick note

The structure of gene drive constructs for population modification

Classic modification gene drive: malaria control (1)

Classic modification gene drive: malaria control (2)

Testing a classic gene drive

Integral gene drives for population modification

Separating gene drive & antimalarial effector modules

An integral gene drive (1)

Ribosome skipping using 2A peptides

An integral gene drive (2)

Testing integral gene drives

Example: the MM-CP integral gene drive effector

When should antimalarial effectors act?

Antimicrobial peptides as promising effectors

Expression of Magainin2 & Melittin from a mosquito midgut gene (1)

Expression of Magainin2 & Melittin from a mosquito midgut gene (2)

Oocyst growth severely impaired in homozygous MM-CP females

Sporozoite development retarded

Reduced lifespan & reproductive output in homozygous MM-CP females

Ross-MacDonald equation

MM-CP allele capable of efficient non-autonomous gene drive

Modelling the impact of deployment on malaria transmission

Modelling the impact of MM-CP propagation on malaria transmission

Testing non-autonomous effectors against patient derived parasites

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved August 14, 2025, from https://doi.org/10.69645/BIMZ7525.