Jak-Inhibitors in Dermatology / edited by Ümit Türsen, Ayşe Serap Karadağ.

Format:

Book

Contributor:

Türsen, Ümit., Editor.

Karadag, Ayse Serap, Editor.

Series:

Medicine Series

Language:

English

Subjects (All):

Dermatology.

Allergy.

Allergology.

Local Subjects:

Dermatology.

Allergology.

Physical Description:

1 online resource (X, 165 p. 8 illus., 6 illus. in color.)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

This book covers the clinical usage of JAK inhibitors, which target Janus kinases and have shown promising results in the treatment of various dermatologic conditions, including atopic dermatitis, psoriasis, vitiligo, connective tissue disorders, autoimmune bullous diseases and alopecia areata. It is likely that JAK inhibitors will continue to play an important role in the management of these conditions, with clinical trials ongoing to assess their safety and efficacy in the treatment of other dermatologic disorders, such as vitiligo and hidradenitis suppurativa. However, it is important to note that JAK inhibitors can have potential side effects, including increased risk of infections, anemia and thrombosis. Therefore, careful monitoring of patients receiving JAK inhibitors is necessary to ensure their safety. Jak Inhibitors in Dermatology represents a treatise on this novel topic and discusses that while JAK inhibitors have shown great promise in the treatment of various dermatologic conditions, further research and monitoring is necessary to fully understand their potential benefits and risks. This book is therefore of great interest for all dermatologists as a first step to understanding this novel treatment.

Contents:

History of The Jak/Stat Pathway

Structures of Jak Inhibitors

Basic Pharmacology and Pharmacokinetics of Jak-Stat Inhibitors

Mechanism of Action

Pan-Jak Inhibitors / Non-Selective Jak Inhibitors

Selective Jak Inhibitor: Abrocitinib (Jak1-Selective)

Selective Jak Inhibitor: Ritlecitinib

Selective Jak Inhibitor: Upadacitinib (Jak1-Selective)

Novel Jak Inhibitors

Dermatological Indications: Atopic Dermatitis

Dermatological Indications: Alopecia Areata

Dermatological Indications: Psoriasis

Dermatological Indications: Vitiligo

Dermatological Indications: E-Other Dermatological Indications

Topical Jak Inhibitors

Safety, Toxicity Profile, and Side Effects

Jak Inhibitors/Drug Interactions

Use of Jak Inhibitors in Dermatology Under Special Conditions

The Future of Jak Inhibitors in Dermatology

Conclusion

Index.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-031-84274-X

OCLC:

1524420837