Neutron Capture Therapy : Principles and Applications / edited by Wolfgang A. G. Sauerwein, Andrea Wittig, Raymond L. Moss, Yoshinobu Nakagawa, Koji Ono.

Format:

Book

Contributor:

Sauerwein, Wolfgang A. G., Editor.

Wittig, Andrea, Editor.

Moss, Raymond L., Editor.

Nakagawa, Yoshinobu., Editor.

Ōno, Kōji, Editor.

Series:

Medicine Series

Language:

English

Subjects (All):

Radiology.

Internal medicine.

Internal Medicine.

Local Subjects:

Radiology.

Internal Medicine.

Physical Description:

1 online resource (XI, 806 p. 287 illus., 203 illus. in color.)

Edition:

2nd ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

This book, now in a revised and updated second edition, provides a comprehensive summary of recent progress in boron neutron capture therapy (BNCT). BNCT is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and to release instantaneously two heavy particles with a path length of one cell diameter or less. This in principle allows for tumor cell-selective high-LET particle radiotherapy. In the past BNCT depended solely on fission reactor-based irradiation facilities, but the appearance of accelerator-based neutron sources placed in hospitals has opened a new chapter for BNCT. This edition covers all the important aspects of BNCT, including neutron sources, boron chemistry, drugs for BNCT, boron analysis and imaging, dosimetry, and radiation biology. The use of BNCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. BNCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in a language that will be readily understood by all participating disciplines.

Contents:

1. Principles of Neutron Capture Therapy

2. History of Boron Neutron Capture Therapy

3. Fission reactor-based neutron irradiation facilities for BNCT

4. Neutron sources: accelerators (principles)

5. Compact Neutron Generator for BNCT

6. Cyclotron-based neutron source, Sumitomo BNCT system, “NeuCure”

7. The accelerator-based BNCT system at the National Cancer Center Hospital (NCCH), Tokyo, Japan.

8. iBNCT, a linac-based neutron source for boron neutron capture therapy, developed by the Tsukuba group

9. Dedicated solutions: Neutron Therapeutics

10. Dedicated solutions: DC tandem accelerator

11. Project of Proton Linac based BNCT system (A-BNCT) in Korea

12. A new neutron irradiation system – Fukushima SiC

13. Neutron capture enhanced fast neutron therapy

14. Boron chemistry

15. Basic Information on Drug Development and Specific Requirements in the Case of BNCT

16. Basics of pharmacokinetics and pharmacodynamics

17. Drugs for BNCT: BSH and BPA

18. A commercially available BNCT Drug: Steboronine® from Stella Pharma

19. Boron Compounds: New Candidates for Boron Carriers in BNCT

20. Boron Analysis and Boron Imaging in BNCT

21. Proteomic Investigations for BNCT

22. Boron Imaging – macroscopic: PET

23. Boron Imaging: Localized quantitative detection and imaging of Boron by Magnetic Resonance

24. In vivo dose distribution imaging

25. Physical Dosimetry and Spectral Characterization of Neutron Sources for Neutron Capture Therapy

26. The Clinical Commissioning of Beams for Neutron Capture Therapy

27. Commissioning of an accelerator-based BNCT facility for clinical purposes

28. Treatment Planning

29. Prescribing and reporting in BNCT

30. Boron Neutron Capture Therapy (BNCT) Radiobiology

31. The Tolerance of BNCT

32. BNCT of oral cavity melanoma in dogs

33. Latest research on radiobiology studies for the application of BNCT to thyroid cancer

34. Clinical trial design and strategies for the implementation of BNCT into clinical practice

35. External Beam BNCT for Glioblastoma Multiforme

36. BNCT, a Useful Modality to Treat Recurrent Malignant Gliomas

37. Boron neutron capture therapy for high-grade meningiomas

38. Malignant Melanoma

39. Head And Neck Squamous Cell Carcinoma: The Helsinki Clinical Trials

40. Clinical results: patients with head and neck squamous cell carcinoma who have no other treatment option

41. Clinical results: salivary gland cancer

42. BNCT for malignant pleural mesothelioma

43. BNCT for multiple or disseminated pleural tumors

44. BNCT for multiple liver metastases

45. Clinical results: Genital tumor

46. Boron Neutron Capture Therapy (BNCT) for soft tissue sarcoma

47. Boron Neutron Capture Therapy for Children with Malignant Brain Tumors

48. Application of Neutron Capture Therapy for Local Recurrent Breast Cancer

49. Boron Neutron Capture Synovectomy

50. Clinical BNCT facilities in Japan

51. Radiation Protection

52. Regulatory aspects and licensing of BNCT facilities.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-031-82591-8

OCLC:

1524424121