Scientific studies supporting development of transcriptomic points of departure for EPA transcriptomic assessment products (ETAPs) / Chang, Dan, [and eighteen others].

Format:

Book

Author/Creator:

Chang, Dan, author.

Language:

English

Subjects (All):

Environmental protection.

Physical Description:

1 online resource

Place of Publication:

Washington, DC : U.S. Environmental Protection Agency, 2024.

Contents:

ABBREVIATIONS

AUTHORS.

CONTRIBUTORS

1. EXECUTIVE SUMMARY

2. BACKGROUND

2.1. WORLDWIDE AND DOMESTIC CHEMICAL LANDSCAPE

2.2. TOXICITY TESTING DATA LANDSCAPE

2.3. HUMAN HEALTH ASSESSMENT LANDSCAPE

2.4. DEVELOPMENT OF THE EPA TRANSCRIPTOMIC ASSESSMENT PRODUCT (ETAP) TO ADDRESS THE HUMAN HEALTH ASSESSMENT GAP

2.5. VALUE OF INFORMATION (VOI) ANALYSIS OF THE POTENTIAL PUBLIC HEALTH AND ECONOMIC TRADE-OFFS OF ETAP

2.6. BOARD OF SCIENTIFIC COUNSELORS (BOSC) SCIENTIFIC REVIEW OF ETAP DEVELOPMENT AND IMPLEMENTATION

3. REVIEW OF TRANSCRIPTOMIC DOSE RESPONSE LITERATURE

3.1. EPA HISTORY, POLICIES, AND USE OF TRANSCRIPTOMICS

3.2. REPRODUCIBILITY OF TRANSCRIPTOMIC DATA

3.3. DOSE CONCORDANCE OF TRANSCRIPTIONAL AND APICAL RESPONSES

3.4. IMPACT OF EXPOSURE DURATION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

3.5. IMPACTS OF CHEMICAL MODE-0F-ACTION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

3.6. SCOPE OF CHEMICAL FUNCTIONAL USE, PROPERTIES, AND TOXICOKINETIC PARAMETERS FOR CHEMICALS WITH TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

3.7. IMPACTS OF ROUTE OF EXPOSURE AND TISSUE SELECTION ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

3.8. IMPACTS OF TECHNOLOGY PLATFORM ON TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

3.9. SUMMARY OF TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE

4. DEVELOPMENT OF TRANSCRIPTOMIC POINTS OF DEPARTURE FOR ETAP

4.1. OVERVIEW OF THE APPROACH TO DERIVE TRANSCRIPTOMIC POINTS OF DEPARTURE FOR ETAP

4.2. ANALYSIS TO SELECT STUDY DESIGN AND TRANSCRIPTOMIC PLATFORM SPECIFIC DOSE RESPONSE MODELING PARAMETERS

4.3. COMPARISON OF TRANSCRIPTIONAL AND APICAL DOSE CONCORDANCE IN THE CONTEXT OF INTER-STUDY VARIABILITY

5. SUMMARY AND CONCLUSIONS

6. APPENDIX

7. REFERENCES.

Notes:

Description based on publisher supplied metadata and other sources.