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Principles of tissue engineering. / Robert Lanza.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Tissue engineering.
- Physical Description:
- 1 online resource
- Edition:
- 5th ed.
- Place of Publication:
- Waltham, Massachusetts : Elsevier, [2020]
- Summary:
- Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade.The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information.
- Contents:
- Front Cover
- Principles of Tissue Engineering
- Copyright Page
- Contents
- List of contributors
- Preface
- 1 Tissue engineering: current status and future perspectives
- Clinical need
- Current state of the field
- Smart biomaterials
- Cell sources
- Embryonic stem cells
- Induced pluripotent stem cells
- Adult stem cells
- Whole organ engineering
- Biofabrication technologies
- Electrospinning
- Inkjet three-dimensional bioprinting
- Extrusion three-dimensional bioprinting
- Spheroids and organoids
- Imaging technologies
- Tissue neovascularization
- Bioreactors
- Organ-on-a-chip and body-on-a-chip
- Integration of nanotechnology
- Current challenges
- Future directions
- Tissue neovasculatization
- Conclusions and future challenges
- References
- Further reading
- 2 From mathematical modeling and machine learning to clinical reality
- Introduction
- Modeling stem cell dynamics
- Positive feedback-based molecular switches
- Variability in stem cell populations
- Modeling tissue growth and development
- Monolayer tissue growth in vitro
- Tissue growth on complex surfaces in vitro
- Three-dimensional tissue growth in vitro
- Pattern formation
- Machine learning in tissue engineering
- Supervised methods
- Unsupervised methods
- Machine learning of cellular dynamics
- Regulatory network inference
- From mathematical models to clinical reality
- 3 Moving into the clinic
- Current state of tissue engineering
- Pathway for clinical translation
- Regulatory considerations for tissue engineering
- Conclusion
- Acknowledgment
- References.
- Further reading
- One: The basis of growth and differentiation
- 4 Molecular biology of the cell
- The cell nucleus
- Control of gene expression
- Transcription factors
- Other controls of gene activity
- The cytoplasm
- The cytoskeleton
- Microtubules
- Microfilaments
- Small GTPases
- The cell surface
- Cell adhesion molecules
- Extracellular matrix
- Signal transduction
- Growth and death
- Culture media
- Cells in tissues and organs
- Cell types
- Tissues
- Organs
- Reference
- General
- Chromatin
- Signaling, general
- Cytoskeleton, adhesion molecules and extracellular matrix
- 5 Molecular organization of cells
- Molecules that organize cells
- Changes in cell-cell adhesion
- Changes in celleextracellular matrix adhesion
- Changes in cell polarity and stimulation of cell motility
- Invasion of the basal lamina
- The epithelial-mesenchymal transition transcriptional program
- Transcription factors that regulate epithelial-mesenchymal transition
- Regulation at the promoter level
- Posttranscriptional regulation of epithelial-mesenchymal transition transcription factors
- Molecular control of the epithelial-mesenchymal transition
- Ligand-receptor signaling
- Growth factor-β pathway
- Wnt pathway
- Signaling by receptor tyrosine kinase ligands
- Notch pathway
- Hedgehog pathway
- Additional signaling pathways
- A model for epithelial-mesenchymal transition induction
- List of acronyms and abbreviations
- Glossary
- 6 The dynamics of cell-extracellular matrix interactions, with implications for tissue engineering
- Historical background
- Extracellular matrix composition
- Receptors for extracellular matrix molecules
- Cell-extracellular matrix interactions
- Development
- Adhesion and migration
- Proliferation.
- Differentiation
- Apoptosis
- Wound healing
- Proliferation
- Differentiation
- Signal transduction events during cell-extracellular matrix interactions
- Relevance for tissue engineering
- Avoiding a strong immune response that can cause chronic inflammation and/or rejection
- Creating the proper substrate for cell survival and differentiation
- Providing the appropriate environmental conditions for tissue maintenance
- 7 Matrix molecules and their ligands
- Collagens
- Fibrillar collagens
- Fibril-associated collagens with interrupted triple helices (FACIT)
- Basement membrane-associated collagens
- Other collagens
- Major adhesive glycoproteins
- Fibronectin
- Laminin
- Elastic fibers and microfibrils
- Other adhesive glycoproteins and multifunctional matricellular proteins
- Vitronectin
- Thrombospondins
- Tenascins
- Proteoglycans
- Hyaluronan and lecticans
- Perlecan
- Small leucine-rich repeat proteoglycans and syndecans
- 8 Morphogenesis and tissue engineering
- Introduction to tissue morphogenesis
- Biology of tissue morphogenesis
- Morphogens as bioactive signaling molecules during morphogenesis
- The extracellular matrix as a key regulator of tissue morphogenesis
- Cell-cell interactions during tissue morphogenesis
- Tissues as integrated systems in the body
- Engineering tissue morphogenesis
- Cells as building units in tissue engineering
- Biomaterial scaffolds as artificial extracellular matrices
- Morphogens as signaling cues in tissue engineering
- Tissue remodeling in healthy and diseased environments
- Current focuses and future challenges
- 9 Gene expression, cell determination, differentiation, and regeneration
- Determination and differentiation.
- MyoD and the myogenic regulatory factors
- Negative regulators of development
- MicroRNAs-regulators of differentiation
- Pax in development
- Satellite cells in skeletal muscle differentiation and repair
- Tissue engineering-repairing muscle and fostering regeneration by controlling determination and differentiation
- Two: In vitro control of tissue development
- 10 Engineering functional tissues: in vitro culture parameters
- Key concepts for engineering functional tissues
- Fundamental parameters for engineering functional tissues
- Fundamental criteria for engineering functional tissues
- Importance of in vitro studies for engineering functional tissues
- In vitro studies relevant to tissue engineering and regenerative medicine
- In vitro platforms relevant for high throughput screening of drugs and other agents
- Influence of selected in vitro culture parameters on the development and performance of engineered tissues
- Culture duration
- Cartilage tissue engineering
- Cardiac tissue engineering
- Biomaterials
- Cartilage tissue-engineering biomaterials
- Fiber-reinforced constructs for cartilage repair
- Stratified and osteochondral constructs for cartilage repair
- Bioinductive and bioactive scaffolds
- Cardiac tissue-engineering biomaterials
- Bioreactors and growth factors
- Cell seeding
- Construct cultivation
- Cartilage tissue-engineering bioreactors
- Cardiac tissue-engineering bioreactors
- Bioreactors and mechanical forces
- Effects of hydrodynamic forces
- Effects of mechanical tension, compression, and shear loading
- Mechanical effects on engineered cartilage tissue
- Electromechanical effects on engineered myocardium
- Acknowledgments
- 11 Principles of bioreactor design for tissue engineering.
- Introduction
- Macrobioreactors
- Design principles
- Mass transport
- Physiological biomimicry cues
- Cell environment
- Sustainable bioreactors
- Cell manufacturing quality attributes and process analytics technology
- Future outlook
- Microgravity bioreactor
- Real-time assessment in the bioreactor
- Microbioreactors
- Flow rheology
- Cell microenvironment
- Integration of multiple compartments
- Types of microreactors
- Components and integration into microreactors
- Applications
- Drug testing and screening
- Experimental models of disease
- Prognostic/diagnostic tools
- Summary
- 12 Regulation of cell behavior by extracellular proteins
- Thrombospondin-1
- Thrombospondin-2
- Tenascin-C
- Osteopontin
- Secreted protein acidic and rich in cysteine
- 13 Cell and matrix dynamics in branching morphogenesis
- The basis of branching morphogenesis
- Branching morphogenesis in the lung
- Branching morphogenesis in the salivary gland
- Branching morphogenesis in the kidney
- Contributions of other cell types
- MicroRNAs in branching morphogenesis
- Extracellular matrix components in branching morphogenesis
- Collagen
- Heparan sulfate proteoglycan
- Fibronectin and integrins
- Basement membrane microperforations
- Mathematical and computational models
- Geometry
- Mechanical forces
- Signaling mechanisms
- 14 Mechanobiology, tissue development, and tissue engineering
- Mechanical forces in biological systems
- Tension
- Compression
- Fluid shear
- Cellular mechanosensing
- Stretch-activated ion channels
- Cell-cell adhesions
- Cell-substrate adhesions
- The extracellular matrix.
- Cellular effects of mechanotransduction.
- Notes:
- Description based on print version record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-12-821401-5
- 0-12-818422-1
- OCLC:
- 1148934799
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