Analytical Techniques for Biomedical Nanotechnology / Ajeet Kaushik, Sesha S. Srinivasan, and Yogendra Kumar Mishra, editors.

Format:

Book

Contributor:

Kaushik, Ajeet, editor.

Srinivasan, Sesha S., editor.

Mishra, Yogendra Kumar, editor.

Series:

IOP Ebooks Series

Language:

English

Subjects (All):

Biomedical engineering.

Physical Description:

1 online resource (529 pages)

Edition:

First edition.

Place of Publication:

Bristol, England : IOP Publishing Ltd, [2023]

Summary:

This book provides a comprehensive overview of analytical techniques for applications in biomedical nanotechnology, at both the fundamental and applied level. It includes a discussion of how fundamental knowledge of techniques can be translated to applications, coverage of state-of-art analytical techniques, and the prospects and challenges of each technique.

Contents:

Intro

Preface

Acknowledgements

Editor biographies

Ajeet Kaushik

Sesha S Srinivasan

Yogendra K Mishra

List of contributors

Chapter 1 Emergence of analytical techniques

1.1 Introduction

1.2 Nanomaterials

1.2.1 Analyte/biomarker

1.3 Electrochemical system

1.3.1 Optical systems (fluorescence, SPR, Raman, mass spectroscopy)

1.3.2 Electron microscope (SEM, TEM, AFM, EDX, XPS)

1.3.3 Magnetic systems (NMR, VSM)

1.3.4 Microfluidic system

1.4 Conclusion and future direction

Acknowledgement

References

Chapter 2 Electrochemical techniques for biomedical nanotechnology

2.1 Introduction

2.2 Principles of electrochemical analytical methods

2.2.1 Potentiometry-based analysis

2.2.2 Voltammetry-based analysis

2.2.3 Amperometry-based analysis

2.2.4 Impedimetry-based analysis

2.3 Status of electrochemical analytical techniques in biomedical nanotechnology

2.3.1 Electrochemical analysis of neurotransmitters

2.3.2 Electrochemical analysis of glucose

2.3.3 Electrochemical analysis of cancer biomarkers

2.4 Recent nanotechnological advancement of electrochemical sensors in biomedicine

2.4.1 Wearable electrochemical sensors

2.4.2 Planar electrochemical sensors

2.4.3 Microfluidic electrochemical sensors

2.5 Conclusion

Chapter 3 UV-visible spectroscopy in biomedical nanotechnology

3.1 Introduction

3.1.1 UV-Vis spectroscopy

3.2 Visible spectrum

3.2.1 Basic principle

3.3 Instrumentation

3.3.1 Light sources

3.3.2 Sources of visible radiation

3.3.3 The monochromator (wavelength selector)

3.3.4 Sample cell

3.3.5 Detectors

3.3.6 Photomultiplier tube detector

3.3.7 The photodiode detector

3.4 Applications of UV-Vis spectroscopy.

3.4.1 Interaction of ZnO nanoparticles with sucrose and honey molecules for biomedical applications

3.4.2 Preparation of aluminum oxide nanoparticles by laser ablation and a study of their applications as antibacterial and wound healing agents

3.4.3 Silver nanoparticles for biomedical application using green synthesis

3.4.4 Synthesis of gold nanoparticles using the green approach for biomedical applications

3.5 Conclusions

Acknowledgment

Chapter 4 FTIR spectroscopy and microscopy in biomedical nanotechnology

4.1 Introduction

4.2 Nanotechnology in biomedical science

4.3 Methods of FTIR spectroscopy and microscopy

4.3.1 FTIR spectroscopy

4.3.2 FTIR microscopy

4.4 FTIR spectroscopy in biomedical applications

4.4.1 Cancer study, diagnosis, and treatment

4.4.2 Nanoscale imaging

4.4.3 Drug release and drug delivery

4.4.4 Bioinformatics

4.4.5 Microbial cell identification and differentiation

4.4.6 Microbial microcolonies

4.4.7 Identification and diagnosis of disease states

4.5 Conclusion

Chapter 5 Raman spectroscopy and microscopy in biomedical nanotechnology

5.1 Introduction

5.2 Raman spectroscopy

5.3 Advanced Raman scattering techniques

5.3.1 Surface-enhanced Raman spectroscopy

5.3.2 Coherent anti-Stokes Raman spectroscopy

5.3.3 Resonance Raman spectroscopy

5.3.4 Spatially offset Raman spectroscopy

5.3.5 Raman microscopy

5.4 Applications

5.4.1 Disease diagnostics

5.4.2 Biomolecule detection

5.4.3 Circulating tumor cell detection

5.4.4 Raman imaging of cells and tissues

5.5 Current challenges and future prospective

Chapter 6 Quartz crystal microbalance for biomedical nanotechnology

6.1 Introduction

6.2 QCM biosensor

6.3 QCM biosensors and nanoparticles

6.4 Potential applications of QCM.

6.4.1 Detection of cell adhesion

6.4.2 Detection of cytotoxicity and cell viability

6.4.3 Detection of phenomena in cells

6.4.4 Detection of VOCs and non-VOCs

6.4.5 Detection of gaseous analytes

6.4.6 Detection of bacteria/pathogen

6.4.7 Detection of biomolecules

6.5 Conclusions and future trends

Chapter 7 Application of nuclear magnetic resonance spectroscopy in biomedical nanotechnology

Abbreviations

7.1 Introduction

7.2 Basics of NMR spectroscopy

7.3 Applications of NMR spectroscopy

7.3.1 NMR application in gold-thiols nanoparticles

7.3.2 NMR application in gold nanoclusters

7.3.3 Application of NMR in drug delivery systems

7.4 Conclusion

Chapter 8 Mass spectroscopy in biomedical nanotechnology

8.1 Introduction

8.2 Biomedical applications of nanoparticles

8.2.1 Magnetic nanoparticles

8.2.2 Bimetallic nanoparticles

8.2.3 Metallic nanoparticles

8.2.4 Metal oxide nanoparticles

8.3 Mass spectroscopy in biomedical applications

8.3.1 Mass spectroscopy for the detection of nanoparticles in neuroscience

8.3.2 Mass spectroscopy for the analysis of sulfur drugs and biothiols using silver nanoparticles

8.3.3 Metal oxide nanoparticle-assisted laser desorption/ionization mass spectrometry for various medical applications

8.3.4 Mass spectrometry imaging of Lepidium meyenii using gold nanoparticles

8.3.5 Mass spectroscopy for the characterization of engineered nanoparticles

8.3.6 Mass spectroscopy for the elucidation of tellurium biogenic nanoparticles

8.3.7 Mass spectrometry analysis of carbon nanomaterials for various applications

8.4 Conclusion

Chapter 9 Magnetic measurement systems for biomedical nanotechnology

9.1 Introduction

9.1.1 Basic characteristics of magnetic materials.

9.1.2 Biomedical nanotechnology

9.2 Magnetic materials

9.2.1 Synthesis of magnetic nanomaterials

9.2.2 Characterization techniques

9.3 Applications of MNPs in medical biotechnology

9.3.1 Magnetic fluid hyperthermia

9.3.2 Drug delivery

9.3.3 Magnetic resonance imaging

9.3.4 Electrochemical sensors

9.3.5 Gene therapy

9.4 Conclusion

Chapter 10 Application of x-ray diffraction for biomedical nanotechnologies: current insights and perspectives

10.1 Introduction

10.2 Instrumentation and sampling of XRD

10.3 Data collection and detection of XRD

10.4 Types of nanoparticles used in XRD

10.4.1 Silver nanoparticles

10.4.2 Gold nanoparticle

10.4.3 Copper nanoparticles

10.4.4 Cadmium sulfide

10.4.5 Metal oxide nanoparticles

10.4.6 Magnetic nanoparticle

10.5 Techniques used by XRD for biomedical nanotechnologies

10.6 Protein crystallography of XRD

10.7 Macromolecule crystallography by XRD

10.8 Drug discovery by XRD

10.9 Impact of XRD on oncology

10.10 Influence of XRD on pharmaceutical industry

10.11 Conclusion

Chapter 11 Scanning electron microscopy for biomedical nanotechnology

11.1 Introduction

11.1.1 Electron backscatter diffraction in SEM

11.1.2 X-ray analysis in SEM

11.1.3 Field emission gun scanning electron microscopy

11.1.4 Cryogenic scanning electron microscopy

11.1.5 Low accelerating voltage SEM

11.1.6 Electron beam (e-beam) lithography integrated SEM

11.1.7 SEM with nanomanipulator

11.1.8 SEM and biomedical applications

11.1.9 Comparison of bone grafts

11.1.10 Study of porosity in scaffolds used in tissue engineering

11.1.11 Orthodontic transplants' microscopic study

11.1.12 SEM in nanoscience

11.1.13 Anatomical studies during surgeries

11.1.14 Challenges and future aspects.

11.2 Conclusion

Chapter 12 Transmission electron microscopy for biomedical nanotechnology

12.1 Introduction

12.1.1 Nanotechnology

12.1.2 Origin of nanotechnology

12.2 Electron microscopy

12.2.1 Invention of electron microscope

12.2.2 EM-working principle

12.2.3 Magnification of electron microscope

12.2.4 Resolving power

12.2.5 Uses of electron microscope

12.3 Transmission electron microscopy

12.3.1 Advancement in transmission electron microscope

12.3.2 Instrumentation of TEM

12.4 Working principle of transmission electron microscopy

12.5 Specimen preparation for TEM

12.6 Applications of TEM in biomedical nanotechnology

12.6.1 Bio-imaging application

12.6.2 Drug delivery application

12.6.3 Biosensor application

12.6.4 Tissue engineering application

12.6.5 Antimicrobial application

12.7 Challenges and future perspective of TEM

12.8 Conclusion

Chapter 13 Energy dispersive spectroscopy for biomedical nanotechnology

13.1 Introduction

13.2 General instrumentation

13.2.1 Detector and its working

13.2.2 Sample preparation

13.3 EDX result analysis for some biological identities

13.3.1 Application of EDS analysis in tissue engineering for element detection

13.3.2 Role of EDS analysis in nanotechnology

13.3.3 Detection of heavy elements in biological samples

13.3.4 EDX analysis of living (wet) plants and animal using the 'NanoSuit' method

13.4 Conclusion and future prospects

Chapter 14 Atomic force microscopy for biomedical nanotechnology

14.1 Introduction

14.2 Basic working principal

14.2.1 Cantilever tip shape

14.2.2 Cantilever stiffness for biological samples

14.3 Calibration

14.3.1 Calibration of cantilever stiffness

14.4 Forces in aqueous solution.

14.5 Models for cell mechanic's study.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9780750344753

075034475X

OCLC:

1429723156