The auditory cerebellum : function and dysfunction / Jos J. Eggermont.

Format:

Book

Author/Creator:

Eggermont, Jos J., author.

Language:

English

Subjects (All):

Audiology.

Physical Description:

1 online resource (0 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2025]

Summary:

The Auditory Cerebellum: Function and Dysfunction focuses on the sensory and cognitive aspects of the cerebellum, with an emphasis on hearing, speech, music, speaking, and singing. This book fills the gap for information needed in audiology and auditory neuroscience, tinnitus, and developmental disorders with a strong auditory component. This book starts with a general overview on the connectivity between the cerebellum and auditory subcortical and cortical areas, including general cortical networks. There are several chapters devoted to the timing aspects of the cerebellum underlying speech and music perception as well as motor aspects in speaking and singing.Also discussed is the role of the cerebellum in hearing impairment, tinnitus, developmental disorders with a strong auditory component, including dyslexia, autism, attention deficit, and hyperactivity disorder. Dr. Jos Eggermont, a leading researcher in the field, uses a systems analysis approach that covers electrophysiology and neural imaging, both in animals and humans.- Discusses the modulating role of the cerebellum in auditory perception, particularly in speech, music, and related disorders- Reviews how developmental disorders show topographical differences in the cerebellum versus in neocortex- Examines studies on the role of the cerebellum in hearing impairment and tinnitus

Contents:

Front Cover

The Auditory Cerebellum

Copyright Page

Contents

About the author

Preface

Abbreviations

1 Anatomy, histology, physiology, and connectivity of the cerebellum

1.1 Large-scale anatomy

1.1.1 Morphology

1.1.2 Topographic functionality

1.2 Comparing the morphology of animal and human cerebellum

1.3 Histology

1.3.1 General

1.3.2 Organization and cell types

1.3.2.1 Granule cells

1.3.2.2 Golgi cells

1.3.2.3 Mossy fibers and climbing fibers

1.3.2.4 Unipolar brush cells

1.3.2.5 Purkinje cell firing patterns

1.3.2.6 Deep cerebellar nuclei

1.4 The cerebellar microcircuit

1.5 Cerebellar output

1.5.1 General

1.5.2 Connectivity with neocortex

1.5.3 Connectivity with brainstem and thalamus

1.5.4 Connectivity with basal ganglia

1.6 Cerebellar plasticity

1.7 Summary

References

2 The cerebellum as a time keeper

2.1 Setting the stage

2.1.1 Timing in the auditory system

2.1.2 Timing in the cerebellum

2.1.3 Specific neuron's involvement

2.1.4 Timing mechanisms in the olivocerebellar system

2.1.5 Time processing in the granular layer

2.2 Evidence of cerebellar involvement in timing from human lesion studies

2.3 If not as a clock, how does the cerebellum perform temporal processing?

2.4 Interaction with cerebral networks

2.5 The human olivocerebellar system

2.6 Role of oscillations

2.7 Summary

3 A cognitive role for the cerebellum

3.1 First suggestions and mixed receptions

3.2 Acceptance

3.3 Topographic analyses

3.3.1 Further evidence for cognitive areas from cerebellar diseases

3.3.2 Studies in healthy subjects

3.3.2.1 Activation

3.3.2.2 Connectivity

3.4 Social cognition

3.5 Working memory in general

3.6 Working memory in music and other auditory tasks

3.7 Working memory and reading.

3.8 Summary

4 The cerebellum and auditory perception

4.1 Early evidence for an auditory function from animal studies

4.1.1 Auditory-evoked potentials

4.1.2 Auditory-evoked single-unit activity

4.2 Response types of cerebellar auditory neurons

4.3 Cerebellar topography of responses to sound

4.4 Further dissecting auditory pathways to the cerebellum

4.4.1 General

4.4.2 Histology

4.4.3 Auditory responses of the (para)flocculus

4.4.4 Towards a connection model for the (para)flocculus

4.4.5 The cerebellar nuclei

4.5 Summary animal studies

4.6 Neuroimaging studies in humans

4.6.1 Cerebellar activation studies

4.6.2 Connectivity studies

4.7 Cerebellar deficits and auditory processing

4.8 Summary topography

4.8.1 Human studies

4.8.2 Comparing animal and human findings

4.9 Overall summary

4.9.1 Animal data

4.9.1.1 Auditory input to the cerebellum

4.9.1.2 Multimodal units in the cerebellum

4.9.1.3 The paraflocculus in particular

4.9.2 Human data

4.9.2.1 Auditory activation

4.9.2.2 Multimodal activation

5 The role of the cerebellum in music, speech, and language perception

5.1 Cerebellum and music perception

5.1.1 Normal perception

5.1.1.1 Cerebellar activation

5.1.1.2 Connectivity studies

5.1.2 Effects of aging in musicians

5.1.3 Lesion studies

5.2 Speech perception

5.2.1 Normal perception

5.2.2 Cerebellar lesions

5.3 Cerebellum and language

5.3.1 Early indications for a cerebellar language area

5.3.2 Gateway through the thalamus

5.3.3 The role of the cerebellum

5.3.3.1 Lateralization and topography

5.3.3.2 Native versus second language

5.4 Summary

5.4.1 Areas involved

5.4.2 Summary by modality

5.4.2.1 Music

5.4.2.2 Speech

5.4.2.3 Language

References.

6 Cerebellum involvement in speaking and singing

6.1 Clinical evidence on speech production

6.1.1 Cerebellar lesions and vocalization

6.1.2 Cerebellar ataxia

6.1.3 Stuttering

6.2 Cerebellar topography of speech production

6.2.1 Activation studies

6.2.2 Connectivity studies

6.3 Cerebellar topography of singing

6.3.1 PET studies

6.3.2 MRI studies

6.4 Further evidence for topographic differences between speaking and singing

6.5 Summary

6.5.1 Topographic comparison

6.5.2 Overall comparison of speaking and singing

6.5.2.1 Speaking

6.5.2.2 Singing

7 Maturation and aging of the cerebellum

7.1 Normal development

7.1.1 Structural

7.1.1.1 Infants

7.1.1.2 Children and adolescents

7.1.2 Functional connectivity

7.1.2.1 Newborns and infants compared to adults

7.1.2.2 Children and adolescents

7.2 Aging

7.2.1 Auditory aspects

7.2.2 Changes in cerebellar volume and neuron numbers

7.2.2.1 Postmortem human material

7.2.2.2 Magnetic resonance imaging studies

7.2.3 Correlation of cerebellar volume with cognition or function

7.3 Neural activity and connectivity

7.3.1 Neural activity and aging

7.3.2 Effects of aging on subcortical and neocortical connectivity

7.4 Summary

7.4.1 Topography and aging

7.4.2 Lifespan changes

7.4.2.1 Development

7.4.2.2 Aging

8 Cognitive developmental disorders

8.1 Introduction

8.2 Dyslexia

8.2.1 Auditory aspects

8.2.2 Cerebellar gray matter volume

8.2.3 Cerebellar activity

8.2.4 Functional connectivity

8.3 Autism spectrum disorder

8.3.1 Auditory aspects

8.3.1.1 Psychoacoustics

8.3.1.2 Evoked potentials

8.3.1.3 Functional magnetic resonance imaging studies

8.3.2 Postmortem cerebellum examinations

8.3.3 Cerebellar gray matter volume in autism spectrum disorder.

8.3.3.1 Early studies

8.3.3.2 More recent studies

8.3.4 Cerebellar activation

8.3.5 Structural and functional connectivity

8.3.5.1 Structural connectivity

8.3.5.2 Functional

8.3.6 Topography and behavior

8.4 Attention-deficit/hyperactivity disorder

8.4.1 Auditory aspects

8.4.2 Cerebellum gray matter volume

8.4.3 Neural activity and functional connectivity

8.4.3.1 Neural activity

8.4.3.2 Structural connectivity

8.4.3.3 Functional connectivity

8.5 Comparing autism spectrum disorder and attention-deficit and hyperactivity disorder

8.6 Comparing topographies

8.6.1 Dyslexia

8.6.2 Autism spectrum disorder

8.6.3 Attention-deficit and hyperactivity disorder

8.7 Overall summary

8.7.1 General

8.7.2 Dyslexia

8.7.3 Autism spectrum disorder

8.7.4 Attention-deficit and hyperactivity disorder

9 Schizophrenia and the cerebellum

9.1 Auditory aspects

9.2 Cerebellar gray matter changes

9.2.1 Mostly structural

9.2.2 Correlations with cognition

9.2.2.1 Some early studies

9.2.2.2 More recent studies

9.3 Regional blood oxygenation level-dependent activity

9.4 The dentate nuclei

9.5 Matter and structural connectivity changes

9.5.1 Graph theoretical metrics

9.5.2 Structural network changes and symptoms

9.6 Functional connectivity

9.7 Brain rhythms in schizophrenia

9.7.1 Neocortical areas

9.7.2 Cerebellum involvement

9.8 Auditory hallucinations

9.8.1 Phenomenology and topography

9.8.2 Prediction errors and auditory verbal hallucination

9.9 Summary

9.9.1 Topography

9.9.2 Detailed summary

10 Dementia and the cerebellum

10.1 The role of hearing loss

10.2 Cerebellar atrophy in dementia

10.2.1 Vascular and perfusion changes

10.2.2 Cerebellar atrophy and cell loss found in postmortem studies.

10.2.3 Neuroimaging studies of cerebellar volume changes in dementia

10.2.3.1 Mild cognitive impairment, Alzheimer's disease, and Lewy body dementia

10.2.3.2 Frontotemporal and other dementias

10.3 Activation and metabolic differences between mild cognitive impairment and Alzheimer's disease

10.4 The cerebellar network and its connectivity changes

10.5 Summary

10.5.1 Summary topography

10.5.2 Detailed summary

11 Cerebellar dysfunction in hearing loss and tinnitus

11.1 Cerebellar involvement in age-related hearing impairment and tinnitus

11.2 Hearing impairment

11.2.1 Animal cerebellum data

11.2.2 Human studies

11.2.2.1 Morphological studies

11.2.2.2 Connectivity studies

11.3 Tinnitus

11.3.1 Tinnitus and hallucinations

11.3.2 Animal cerebellum data on tinnitus

11.3.2.1 Role of unipolar brush cell activity changes in tinnitus

11.3.2.2 Cerebellar interaction with the cerebral auditory system

11.3.3 Human studies

11.3.3.1 Gray matter volume

11.3.3.2 Activation studies

11.3.3.3 Connectivity studies

11.4 Summary

11.4.1 Human topography

11.4.2 Summarizing human findings

11.4.2.1 Hearing loss

11.4.2.2 Tinnitus

12 Does the cerebellum predict?

12.1 Error-driven learning

12.2 Prediction versus timing

12.2.1 Cerebellar lesions

12.2.2 Models of cerebellar temporal processing

12.3 The role of attention in prediction

12.4 Internal models and predictive computation

12.4.1 Internal models

12.4.2 Predictive coding in the animal cerebellum

12.4.3 Human studies

12.5 Prediction networks in general

12.6 Summary

13 The cerebellum in auditory-related disorders: an underresearched area

13.1 Auditory cerebellar areas

13.1.1 Results from animal studies

13.1.2 According to human studies.

13.2 Human auditory topography in cognitive disorders.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780443298486

0443298483

OCLC:

1498868833