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The Nervous System / Mayeen Uddin Khandaker and Mohsin Kazi, editor.
- Format:
- Book
- Series:
- Stem Cell Innovation in Health and Disease Series
- Stem Cell Innovation in Health and Disease Series ; Volume 5
- Language:
- English
- Subjects (All):
- Nervous system--Diseases--Treatment.
- Nervous system.
- Stem cells--Therapeutic use.
- Stem cells.
- Physical Description:
- 1 online resource (201 pages)
- Edition:
- First edition.
- Place of Publication:
- London : Academic Press, [2025]
- Summary:
- The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics.
- Contents:
- Front Cover
- The Nervous System
- Copyright Page
- Contents
- List of contributors
- About the editors
- Preface
- Acknowledgment
- General introduction
- 1 Stem cell-based organoid culture system as an innovative model of the central nervous system development and disease system
- Introduction
- Organoid
- Organoids as disease models and their medical applications
- Brain organoid
- Current methodologies of generating three-dimensional brain organoids
- Approaches to disease
- Cellular competent organoid model: integration of cell compartments
- Neuroimmune organoids: contribution of the innate and adaptive immune cells
- Modeling neurodegenerative disorders
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
- Modeling brain cancer
- Conclusion
- References
- 2 Applying innovative genome editing technologies (e.g., CRISPR/Cas9 systems) in stem cell engineering and neurological disorders and diseases
- Stem cells
- Embryonic
- Stem cell applications in tissue engineering
- Stem cells and their fate
- CRISPR-Cas gene-editing system
- Discovery and development of CRISPR technology
- A unique pattern of recurrent intervals
- The boom in CRISPR technology
- Gene editing in animal cells
- CRISPR-Cas9 in neurodegenerative diseases
- Mechanism of CRISPR/Cas9 system
- Adaptation
- Interference
- Glioblastoma
- Epilepsy
- 3 Role of genetically engineered and modified animal models in investigating neurogenic diseases and disorder
- Evolutional and neurobiological understanding of psychopathology
- Opportunities provided by companion animal models of neurological disease
- Obstacles to the use of companion animal models in neuroscience research.
- Challenges for producing animal models of mental illness
- Evaluating animal models of neuropsychiatric disorders
- Genome editing in large animals
- Spontaneous neurological diseases in companion animals
- Stroke
- Alzheimer's disease and cognitive dysfunction syndrome
- 4 Stem cell therapeutics in neurological disorders: classification, mechanisms and clinical applications
- Stem cell as a therapeutic platform
- Stem cell classification
- Why stem cell transplantation therapy?
- Clinical application with stem cell transplantation and other cell therapies in neurological diseases
- Amyotrophic lateral sclerosis
- Multiple sclerosis
- Preclinical studies
- Clinical studies
- Hematopoietic stem cell transplantation
- Mesenchymal stem cell transplantation
- Neural stem cells
- Mesenchymal stem cells
- Induced pluripotent stem cells
- 5 Emerging trends in stem cell-based treatments for neurodegenerative diseases
- Classification based on differential potency
- Classification based on the origin
- Subclassifications of adult stem cells
- Stem cell-based therapies for Alzheimer's
- Overview
- Mechanisms of Alzheimer's disease progression
- Studied treatment for Alzheimer's disease
- Stem cell therapy for Parkinson's
- Mechanisms of Parkinson's disease progression
- Studied treatment for Parkinson's disease
- Stem cell therapies for amyotrophic lateral sclerosis
- Mechanism of amyotrophic lateral sclerosis
- Studied treatment for amyotrophic lateral sclerosis
- 6 Derivation and application of haploid neural stem cells in central nervous system disorders and diseases.
- Introduction
- Strokes
- Details of stem cell in stroke recovery
- Spinal cord injury
- Two spinal cord injuries/disorders + stem cell implications
- 7 Mesenchymal stem cell-related therapies for neurological diseases and disorders
- List of abbreviations
- Therapeutic potential of mesenchymal stem cell-mediated therapy
- Neuroregeneration
- Migration
- Immunomodulation
- Current treatments
- Pharmacological treatments
- Nonpharmacological and behavioral care strategies
- Mesenchymal stem cell-related therapies
- Future directions in research
- Pathophysiology
- Future prospects
- 8 The gold standard induced pluripotent stem cells and induced pluripotent stem cell-derived neural cells in modeling neurological diseases
- Production of induced pluripotent stem cells
- Neural differentiation of induced pluripotent stem cells
- Neural cultures in vitro
- Induced pluripotent stem cell-derived cells in neurological disease modeling
- Limitations of induced pluripotent stem cells
- Conclusions and future prospects
- 9 Stem cell innovation in neurological and neurodegenerative disorders: general conclusion, challenges, and prospective
- Roles of the organoids and gene-editing technology in modeling and investigating neurological and neurodegenerative disorders/diseases
- Genome editing technologies in neurological disorders and diseases
- Stem cell-based therapy of neurological disorders and diseases
- Conflicts of interest
- Index
- Back Cover.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780443274152
- 0443274150
- OCLC:
- 1504142890
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