Biopolymer networks : design, dynamics and discovery / Rae M. Robertson-Anderson.

Format:

Book

Author/Creator:

Robertson-Anderson, Rae M., author.

Contributor:

Institute of Physics (Great Britain), publisher.

Series:

IOP (Series). Release 24.

Biophysical Society-IOP series.

IOP ebooks. 2024 collection.

[IOP release $release]

Biophysical Society-IOP series

IOP ebooks. [2024 collection]

Language:

English

Subjects (All):

Biopolymers.

Polymer networks.

Local Subjects:

Biopolymers.

Polymer networks.

Physical Description:

1 online resource (various pagings) : illustrations (some color).

Place of Publication:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2024]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Biography/History:

Rae M. Robertson-Anderson is Professor of Physics and Biophysics and Associate Provost for Engaged Scholarship at the University of San Diego, where she has established an internationally recognized research program to elucidate macromolecular dynamics and microscale mechanics of bio-inspired soft and active matter systems. Robertson-Anderson is a leading expert in the design of novel microrheology methods and complex biopolymer composites to address critical questions in soft matter physics and cell biology. She is equally passionate about promoting and advancing undergraduate research and education, and building community among diverse scientists and with the general public. Robertson-Anderson has been awarded over $5M in grants to support her research, and her 74 publications feature 85 undergraduate co-authors.

Summary:

This reference text provides a broad overview of biopolymer networks written for an interdisciplinary audience of cellular and molecular biologists, soft matter and polymer physicists, materials scientists, and chemical engineers. It opens with an introduction to biopolymers and their networks, followed by an overview of important polymer physics theories and concepts, experimental tools to measure network properties, and computational analysis techniques to characterize and interpret data. The book follows with a description of model biopolymer networks--from design to rheology--before embarking on a discussion of novel network designs and their emergent physical properties, including topologically-novel polymers, composites, active matter, and liquid-liquid phase separation. It closes with a community-led perspective on key open questions and grand challenges, and how we may come together to advance understanding of biopolymer networks and their utility in diverse applications. Part of Biophysical Society-IOP series.

Contents:

part I. Let's get started. 1. Introduction to biopolymers and their networks

1.1. Polymers 101

1.2. Biopolymer basics

1.3. Biopolymer networks in biology

1.4. Biopolymer networks in physics and engineering

1.5. What next?

part II. Making sense and measuring. 2. Polymer physics for everyone

2.1. The beauty of polymer physics

2.2. Polymer flexibility

2.3. Single polymer conformations

2.4. Single polymer dynamics

2.5. Beyond the standard tube model

2.6. Rheology

2.7. Semiflexible polymers

2.8. Rigid rod polymers

2.9. Crosslinked polymer networks

2.10. Nonlinear viscoelasticity

2.11. To be continued ...

3. Measuring mechanics, dynamics, and structure

3.1. Direct imaging of biopolymers

3.2. Direct measurements of force, stress, and dynamics

3.3. What's next

4. Analysis methods, algorithms, and deliverables

4.1. Single-molecule center-of-mass tracking

4.2. Single-particle tracking (SPT)

4.3. Particle-image velocimetry (PIV)

4.4. Differential dynamic microscopy (DDM)

4.5. Spatial image autocorrelation

4.6. Advanced techniques and further reading

5. Biopolymer network design, dynamics, and mechanics

5.1. DNA solutions : from dilute to highly entangled

5.2. Entangled and crosslinked actin networks

5.3. Entangled and crosslinked networks of microtubules

5.4. Intermediate filament (IF) networks

5.5. Canonical building blocks for complex biopolymer networks

part III. Beyond the basics

novel and complex networks. 6. Networks of topologically-novel biopolymers

6.1. Relaxed circular (ring) biopolymers

6.2. Supercoiled circular biopolymers

6.3. Concatenated ring biopolymers

6.4. Branched biopolymers

6.5. Building in complexity

7. Biopolymer composites, blends, and crowding

7.1. Biopolymer blends

7.2. Biopolymer composites

7.3. Considerations and outlook

part IV. Spatiotemporal heterogeneity : from active matter to coacervates. 8. Active, responsive, and reconfigurable networks

8.1. Motor-driven cytoskeleton networks

8.2. Chemically-triggered biopolymer networks

8.3. Non-equilibrium DNA networks

8.4. Considerations and outlook

9. Self-assembly and phase separation

9.1. Beyond local heterogeneity

9.2. Introduction to liquid-liquid phase separation (LLPS)

9.3. Crowding and liquid-liquid phase separation

9.4. Complex coacervates

9.5. LLPS of intrinsically disordered proteins

9.6. LLPS of nucleic acids

9.7. Structurally heterogeneous condensates

9.8. Active and dynamic liquid-liquid phase separation

9.9. Viscoelastic phase separation (VPS)

9.10. Considerations and outlook

part V. What now? 10. Past, present, and future : perspectives from the community

10.1. What we have learned

10.2. What we are still learning

10.3. Who 'we' are and what we think

10.4. What are the big open questions in the field of biopolymer networks?

10.5. What is needed in the research community to make advances in the field?

10.6. What is a 'must-read' for anyone interested in learning more about the field?

Notes:

"Version: 20240801"--Title page verso.

Includes bibliographical references.

Title from PDF title page (viewed on September 3, 2024).

Other Format:

Print version:

ISBN:

9780750350372

9780750350365

OCLC:

1455015905

Access Restriction:

Restricted for use by site license.