Role of inflammation in the pathogenesis of Parkinson's disease / Malú Gámez Tansey.

Format:

Video

Author/Creator:

Tansey, Malú Gámez, author.

Language:

English

Subjects (All):

Brain--Metabolism.

Brain.

Gastrointestinal system--Microbiology.

Gastrointestinal system.

Physical Description:

1 streaming video file (37 min., 56 sec.) : color, sound

Place of Publication:

London : Henry Stewart Talks Ltd, 2025.

System Details:

video file

Contents:

Introduction

Disclosures

Unifying mechanisms

Neuroimmune crosstalk

Microglia and macrophages

Peripheral vs. CNS immune responses

How and when?

Human longevity, genetics and inflammation

The janus head of immune aging

Inflammation to neurodegeneration

Acute inflammation

Chronic inflammation

How inflammation links to dementia

Innate immune dysfunction

Involvement of gut microbiota

Signaling inflammation across the GBA

GBA in inflammation-associated diseases

Motor and non-motor PD symptoms

The perfect storm for PD development

Non-motor PD symptoms

Body first vs. brain first

Environmental toxicants

Gut barrier is critical for brain health

Intestinal inflammation

What do we know?

Gut dysbiosis

Inflammation, loss of SCFAs and leaky gut

Short-Chain Fatty Acids (SCFAs)

Association between IBD and PD risk

Inflammatory bowel disease (IBD)

PD and IBD gut microbiome comparison

Demographics of publicly available datasets

ANCOM-BC2 differential abundance analyses

Shared depletion: Bacteria

Shared depletions: SCFA-synthesis pathways

Comparison to UFPF dataset

Similarities in taxonomic depletions

Conclusions

Take home message.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved August 14, 2025, from https://doi.org/10.69645/BEAA4322.