A Guide to Breast Cancer Research : From Cellular Heterogeneity and Molecular Mechanisms to Therapy / edited by Therese Sørlie, Robert B. Clarke.

Format:

Book

Author/Creator:

Sørlie, Therese.

Contributor:

Clarke, Robert B.

Series:

Advances in Experimental Medicine and Biology, 2214-8019 ; 1464

Language:

English

Subjects (All):

Cancer.

Oncology.

Cancer--Treatment.

Metastasis.

Tumors--Immunological aspects.

Tumors.

Cancer Biology.

Cancer Therapy.

Tumour Immunology.

Local Subjects:

Cancer Biology.

Oncology.

Cancer Therapy.

Metastasis.

Tumour Immunology.

Physical Description:

1 online resource (926 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

The book presents key topics at the forefront in breast development and cancer research in chapters authored by leading scientists in the field. The chapters provide a basis for understanding major concepts, model systems, cells of origin and heterogeneity in human breast development and cancer. The book builds on this understanding to guide readers through the cellular and molecular basis of breast cancer and the most important signaling pathways. Finally, the book describes mechanisms of metastasis and cancer immunity, and treatment options and resistance to therapy. It is targeted at young scientists and early career researchers and provides an overview of current topics in breast cancer research. Each chapter includes key learning points, boxes and conclusions to highlight the most important information. This book will interest anyone who wants to learn about the main areas of breast cancer research and the most important recent advances.

Contents:

Part I: Development and cancer: basic concepts

Chapter 1: Introductory chapter by Sorlie and Clarke

Chapter 2: Embryonic mammary gland morphogenesis

Chapter 3: Breast morphogenesis: from normal development to cancer

Chapter 4: Single-Cell Analysis in the Mouse and Human Mammary Gland

Part II: Development and cancer: model systems and approaches

Chapter 5: Recording lineage history with cellular barcodes in the mammary epithelium and in breast cancer

Chapter 6: Models for studying ductal carcinoma in situ progression

Chapter 7: Patient-derived xenografts of breast cancer

Chapter 8: Rat Models of Breast Cancer

Part III: Development and cancer: cells of origin and heterogeneity

Chapter 9: Cells of origin of breast cancer and intertumoral heterogeneity

Chapter 10: Mechanisms of regulation of cell fate in breast development and cancer

Chapter 11: Classification of breast cancer through the perspective of cell identity models

Part IV: Cellular and molecular basis

Chapter 12: The Microenvironment in DCIS and its Role in Disease Progression

Chapter 13: Molecular basis of breast tumor heterogeneity

Chapter 14: E-cadherin-mediated cell-cell adhesion and invasive lobular breast cancer

Part V: Signalling pathways

Chapter 15: Hormone signaling in breast development and cancer

Chapter 16: RANK/RANKL signaling pathway in breast development and cancer

Chapter 17: Metabolic Reprogramming and Adaption in Breast Cancer Progression and Metastasis

Part VI: Metastasis and immunity

Chapter 18: Microenvironmental regulation of dormancy in breast cancer metastasis: “An ally that changes allegiances”

Chapter 19: The Roles of Myeloid Cells in Breast Cancer Progression

Chapter 20: Immune microenvironment in breast cancer metastasis

Part VII: Subtypes, treatment and resistance

Chapter 21: Clinical Implications of Breast Cancer Intrinsic Subtypes

Chapter 22: Targeting Estrogen Receptor signalling in breast cancer therapy

Chapter 23: CDK4/6 inhibitor resistance in ER+ breast cancer

Chapter 24: HER2-positive breast cancer treatment and resistance.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9783031708756

303170875X

OCLC:

1498702204