Enzymatic Targets for Drug Discovery Against Alzheimer's Disease / Dileep Kumar and Prashant Tiwari.

Format:

Book

Author/Creator:

Kumar, Dileep, author.

Tiwari, Prashant, author.

Language:

English

Subjects (All):

Alzheimer's disease.

Physical Description:

1 online resource (289 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Ltd., [2023]

Summary:

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer's disease (AD). It brings together researchers across the globe having varied scientific backgrounds and expertise in a single volume.The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment. The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies. Readership Students and researchers in the field of neuroscience, medicine and pharmacology.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Recent Advances In Tacrine-Based Anti-Alzheimer’s Drug Design

Atukuri Dorababu1,*

INTRODUCTION

Multi-Target Anti-Alzheimer’s Agents

Tacrine-Heterocycle Hybrids

Tacrine - Non-Heterocycle Hybrids

Cholinesterase Inhibitors

Tacrine-Heterocycle Based ChE Inhibitors

Tacrine-Non-Heterocycle-Based Derivatives

DISCUSSION AND CONCLUSION

REFERENCES

Epigenetics of Alzheimer’s Disease: Past, Present and Future

Divya Adiga1, Sangavi Eswaran1, S. Sriharikrishnaa1, Nadeem G. Khan1, Shama Prasada Kabekkodu1,* and Dileep Kumar2,3

Alzheimer’s Disease (AD)

ROLE OF EPIGENETIC MODIFICATIONS IN AD

DNA Methylation

Hydroxy-Methylation

Mitochondrial DNA Methylation

Histone Modifications

Non Coding RNAs (ncRNAs)

Long-Non Coding RNAs (LncRNAs) in AD Pathogenesis Generated by AI.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

Includes bibliographical references.

ISBN:

9789815136142

9815136143

OCLC:

1416923137