Acute Lymphoblastic Leukemia in Children and Adolescents / edited by Gabriele Escherich, Valentino Conter.

Format:

Book

Author/Creator:

Escherich, Gabriele.

Contributor:

Conter, Valentino.

Series:

Pediatric Oncology, 2191-0812

Language:

English

Subjects (All):

Hematology.

Pediatrics.

Oncology.

Local Subjects:

Hematology.

Pediatrics.

Oncology.

Physical Description:

1 online resource (387 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2024.

Summary:

This book is a comprehensive and up-to-date compendium on diagnosis, treatment and late effects of Acute Lymphoblastic Leukemia in children, adolescents and young adults. After introductory chapters on the epidemiology and biology of ALL, treatment considerations are extensively reviewed, also with emphasis on special patient groups, such as Infants, Adolescents and patients with Down Syndrome. Immunotherapy in Acute Lymphoblastic Leukemia is reviewed as well as strategies for patients with Lymphoblastic Lymphoma and for patients with refractory or relapsed ALL. The authors are internationally recognized experts and offer up-to-date insights on etiology, biology, and treatment. This book will prove indispensable for those treating or researching into this disease.

Contents:

Part I: Epidemiology and Predisposition of ALL. Genetic predisposition for leukemia

Association of leukemia with genetic diseases. Part II: Biology and Diagnostics of ALL. Genetic aberrations and profiles in Bcp ALL

Genetic aberrations and profiles in T ALL

Features of ALL in children, adolescents, and young adults

Immunological Diagnosis

MRD response: FCM, Ig/Tcr PCR, NGS. Part III: Stratification and treatment considerations in ALL. Stratification and treatment of Bcp ALL and T-ALL

Stratification and treatment of Adolescents/AYA

CNS therapy

Stratification and treatment of Down Syndrome

Stratification and treatment of Infants

Stratification and treatment of BCR/ABL and ABL class fusion. Part IV: Immunotherapy in ALL. Immunotherapy with monoclonal antibodies

Immunotherapy with CAR-T. Part V: Strategies for patients with Lymphoblastic Lymphoma/mature B-ALL. Stratification and treatment of lymphoblastic lymphomas

Stratification and treatment of mature B ALLs. Part VI: Strategies for patients with refractory or relapsed ALL. Relapses: classification and treatment

HSCT in 1rst CR and after subsequent CRs: indications, conditioning regimens. Part VII: Toxicity and Late effects following ALL treatment. Genetic disposition for toxicity Late toxicity including SMN

late effects after HSCT. Part VIII: Perspectives and Future directions

Global disparities in ALL treatment and outcome

New agents.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Escherich, Gabriele Acute Lymphoblastic Leukemia in Children and Adolescents

ISBN:

9783031711800

OCLC:

1484071304