Biochemical Mechanisms for Metabolic Syndrome / edited by Tejal Gandhi, Anita Mehta.

Format:

Book

Author/Creator:

Gandhi, Tejal.

Contributor:

Mehta, Anita.

Series:

Advances in Biochemistry in Health and Disease, 2512-2150 ; 31

Language:

English

Subjects (All):

Metabolism.

Metabolism--Disorders.

Biochemistry.

Cytology.

Medical genetics.

Medical microbiology.

Metabolic Disease.

Metabolic Pathways.

Medical Genetics.

Medical Microbiology.

Local Subjects:

Metabolism.

Metabolic Disease.

Biochemistry.

Metabolic Pathways.

Medical Genetics.

Medical Microbiology.

Physical Description:

1 online resource (586 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2024.

Summary:

The book "Biochemical Mechanisms for Metabolic Syndrome" delves into the intricate biochemistry underlying the complex condition known as Metabolic Syndrome. The main focus of the book is to provide a comprehensive overview and in-depth exploration of the various biochemical processes and molecular mechanisms contributing to the development and progression of Metabolic Syndrome. The book is structured into several chapters, each with a specific purpose. The initial chapters, lay the groundwork by introducing the concept of Metabolic Syndrome, its historical context, prevalence, and the risk factors associated with it. Subsequent chapters tackle various aspects of insulin resistance and its underlying mechanisms, lipid metabolism dysregulation, the impact of obesity, and the complex interplay between Metabolic Syndrome and hypertension. The book then shifts focus to exploring the genetic predisposition to Metabolic Syndrome and delves into recently explored indepth cellular and tissue mechanisms, including the role of gut barrier dysfunction and adipose tissue remodeling. Chapters dedicated to molecular mechanisms and signaling pathways offer a deeper understanding of the inflammatory resolution, and endoplasmic reticulum stress in the context of Metabolic Syndrome. Another significant aspect of the book is the exploration of the Brain-Gut-Adipose Axis and endocrine regulation, looking at the impact of gut microbiota-derived metabolites, gut hormones, and neuronal regulation on Metabolic Syndrome. Additionally, omics technologies are covered extensively, ranging from genomics, transcriptomics, proteomics, and epigenomics, to unravel the molecular complexity of Metabolic Syndrome. The latter part of the book delves into therapeutic approaches, including lifestyle interventions, pharmacological interventions, and dietary strategies. It also explores the therapeutic potential of brown adipose tissue, and highlights future directions and emerging research in the field of Metabolic Syndrome biochemistry. Overall, the book will provide a valuable resource for researchers, healthcare professionals, and students seeking a comprehensive understanding of the biochemical intricacies of Metabolic Syndrome and potential avenues for therapeutic interventions.

Contents:

Part I: Overview and Introduction to Metabolic Syndrome

1. The biochemical symphony of metabolic syndrome: An intricate introduction

2. Insulin resistance and its biochemical basis in metabolic syndrome

3. Lipid metabolism dysregulation: Impact on metabolic syndrome

4. The weighty impact: Exploring the importance of obesity in metabolic Syndrome

5. Connecting the dots: The complex relationship between metabolic syndrome and hypertension

6. The orchestra of genetics: Genetic predisposition to metabolic syndrome Prachi Kariaa and Kirti Patela

Part II: Cellular and Tissue Mechanisms in Metabolic Syndrome

7. cGAS-STING: A regulator of intestinal barrier dysfunction and metabolic syndrome

8. Adipose tissue remodeling and metabolic syndrome progression

9. Mitochondrial dysfunction, metabolic syndrome and the Pathogenesis of Metabolic Diseases

Part III. Emerging Molecular Mechanisms and Signaling Pathways

10. Inflammatory resolution and its relevance to metabolic syndrome

11. Role of Brain Natriuretic Peptide in Metabolic and Hypertrophic Heart Failure

12. Endoplasmic reticulum stress and unfolded protein response in metabolic syndrome

13. The Impact of Nrf2 Signalling Pathway in Redox Regulation, Inflammation Attenuation, and Management of Metabolic Syndrome: A Systematic Review

Part IV. Brain-Gut-Adipose Axis and Endocrine Regulation

14. Gut Microbiota-derived metabolites and their impact on Obesity

15. The Impact of Gut Hormones and the Gut-Adipose-Liver Axis in Metabolic Syndrome: An Overview of Nrf2 Involvement in the Signaling Pathways

16. Neuronal regulation of thermogenesis and energy expenditure in Metabolic syndrome

17. Endocrine interplay in metabolic syndrome

Part V. Omics Technologies: Unraveling the Molecular Complexity of Metabolic Syndrome

18. Understanding Cardiometabolic Diseases through Transcriptomic approach

Part VI. Current Therapies and Future Perspectives of Metabolic Syndrome

19. Metabolic Syndrome Management through Omega-3 polyunsaturated fatty acids and Antioxidant-Rich Diets: An Approach from Marine and Vegetarian Sources

20. Pharmacological Interventions of Metabolic Syndrome

21. Metabolic syndrome and associated cognitive dysfunction: a pharmacological perspective

22. Brown adipose tissue and its therapeutic potential for Metabolic Syndrome

23. Bariatric Surgery and Metabolic Syndrome

24. Complementary and Alternative medicine in Metabolic Syndrome Management

25. Future Directions and Emerging Research in Metabolic syndrome.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9783031756863

OCLC:

1482098066