Immunology : A Short Course.

Format:

Book

Author/Creator:

Coico, Richard.

Contributor:

Sunshine, Geoffrey.

Language:

English

Subjects (All):

Immune System Processes.

Physical Description:

1 online resource (433 pages)

Edition:

7th ed.

Place of Publication:

New York : John Wiley & Sons, Incorporated, 2015.

Summary:

Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: Has been fully revised and updated, with a brand new art program to help reinforce learning Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area Highlights important therapeutic successes resulting from targeted antibody therapies Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications.

Contents:

Intro

Title Page

Copyright Page

Contents in Brief

Contents

About the Authors

Contributors

Preface and Acknowledgments

How to Use Your Textbook

About the Companion Website

Chapter 1 Overview of the Immune System

Introduction

Innate and Adaptive Immunity

Innate Immunity

Adaptive Immunity

Clonal Selection Theory

Active, Passive, and Adoptive Immunization

Major Characteristics of the Adaptive Immune Response

Cells Involved in the Adaptive Immune Response

Humoral and Cellular Immunity

Humoral Immunity

Cell-Mediated Immunity

Generation of Diversity in the Immune Response

Benefits of Immunology

Damaging Effects of the Immune Response

The Future of Immunology

The Short Course Begins Here

References and Bibliography

Chapter 2 Innate Immunity

Physical and Chemical Barriers of Innate Immunity

Origin, Differentiation, and Characterizationof Cells of the Innate Immune System

Pattern Recognition: The Hallmark of Innate Immune Responses

Pattern Recognition Receptors

Complement

Intracellular and Extracellular Killing of Microorganisms

Inflammation

Hallmark Signs of Inflammation

Localized Inflammatory Responses

Chronic Inflammation

Fever

Review Questions

Answers to Review Questions

Chapter 3 Adaptive Immunity

Cells and Organs Involved in Adaptive Immunity

The Lymphatic Organs

Lymphocyte Migration and Recirculation

The Fate of Antigen after Penetration

Frequency of Antigen-Specific Naïve Lymphocytes

Interrelationship between Innate and Adaptive Immunity

Chapter 4 Immunogens and Antigens

Requirements for Immunogenicity

Foreignness

High Molecular Weight

Chemical Complexity

Degradability.

Haptens

Further Requirements for Immunogenicity

Primary and Secondary Responses

Antigenicity and Antigen-Binding Site

Epitopes Recognized by B Cells and T Cells

Major Classes of Antigens

Binding of Antigen with Antigen-Specific Antibodies or T Cells

Cross-Reactivity

Adjuvants

Chapter 5 Antibody Structure and Function

Isolation and Characterization of Immunoglobulins

Structure of Light and Heavy Chains

Domains

Hinge Region

Variable Region

Immunoglobulin Variants

Isotypes

Allotypes

Idiotypes

Structural Features of IgG

Biologic Properties of IgG

Agglutination and Formation of Precipitate

Passage through the Placenta and Absorption in Neonates

Opsonization

Antibody-Dependent Cell-Mediated Cytotoxicity

Activation of Complement

Neutralization of Toxins

Immobilization of Bacteria

Neutralization of Viruses

Structural Features of IgM

Biologic Properties of IgM

Complement Fixation

Neonatal Immunity and First Line of Humoral Defense

Agglutination

Isohemagglutinins

Structural and Biologic Properties of IgA

Biologic Properties of IgA

Role in Mucosal Infections

Bactericidal Activity

Antiviral Activity

Structural and Biologic Properties of IgD

Structural and Biologic Properties of IgE

Importance of IgE in Parasitic Infections and Hypersensitivity Reactions

Kinetics of the Antibody Response Following Immunization

Primary Response

Secondary Response

The Immunoglobulin Superfamily

Chapter 6 Antigen-Antibody Interactions, Immune Assays, and Experimental Systems

Antigen-Antibody Interactions.

Primary Interactions Between Antibody and Antigen

Association Constant

Affinity and Avidity

Secondary Interactions between Antibody and Antigen

Agglutination Reactions

Precipitation Reactions

Immunoassays

Direct-Binding Immunoassays

Solid-Phase Immunoassays

Immunofluorescence

Direct Immunofluorescence

Indirect Immunofluorescence

Flow Cytometry

Immunoabsorption and Immunoadsorption

Cellular Assays

Assays of Lymphocyte Function

B-Cell and T-Cell Proliferation Assays

Antibody Production by B Cells

Effector Cell Assays for T Cells and Natural Killer Cells

Cell Culture

Primary Cell Cultures and Cloned Lymphoid Cell Lines

B-Cell Hybridomas and Monoclonal Antibodies

T-Cell Hybridomas

Genetically Engineered Molecules and Receptors

Experimental Animal Models

Inbred Strains

Adoptive Transfer

SCID Mice

Thymectomized and Congenitally Athymic (Nude) Mice

Transgenic Mice and Gene Targeting

Transgenic Mice

Knockout and Knock-in Mice

Analysis of Gene Expression

Microarrays to Assess Gene Expression

Chapter 7 The Genetic Basis of Antibody Structure

A Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression

Genetic Events in Synthesis of Ig Chains

Organization and Rearrangement of Light-Chain Genes

κ-Chain Synthesis

λ-Chain Synthesis

Organization and Rearrangement of Heavy-Chain Genes

Allelic Exclusion and the Regulation of Ig Gene Expression

Class or Isotype Switching

Generation of Antibody Diversity

Presence of Multiple V Genes in the Germline

VJ and VDJ Combinatorial Association

Random Assortment of H and L Chains

Junctional Diversity

Somatic Hypermutation

Somatic Gene Conversion.

Role of Activation-Induced Cytidine Deaminase in Generating Antibody Diversity

Chapter 8 Biology of the B Lymphocyte

Development of B Lymphocytes

Overview

Sites of Early B-Cell Differentiation

Pro-B and Pre-B Cells: First Ig Rearrangements

Immature B Cells

Transitional B cells

Mature B Cells

Plasma Cells

Memory B Cells

Sites of Antibody Synthesis

Interaction of Antigen, B Cells, and Helper T Cells in the Lymph Node

Events in the Germinal Center

Antibody Synthesis in Mucosal Tissue

Thymus-Independent Antibody Responses

B-Cell Membrane Proteins

Stage-Specific Markers

Antigen-Binding Molecules: Membrane Immunoglobulin

Signal Transduction Molecules Associated with Membrane Immunoglobulin

Molecules Involved in T-B Cell Interactions

Homing

Intracellular Signaling in B Cells

Chapter 9 How T Cells Recognize Antigen: The Role of the Major Histocompatibility Complex

How The MHC Got Its Name

MHC Role in Antigen Presentation

Different MHC Molecules Are Expressed by Distinct Host Cells and Interact with Different Sets of T Cells

MHC Class I

MHC Class II

Variability of MHC Class I and MHC Class II Molecules

Structure of MHC Class I and Class II Molecules

Structure of MHC Class II Molecules

Antigen Processing and Presentation: How MHC Molecules Bind Peptides and Create Ligands That Interact with T Cells

Exogenous Antigens and Generation of MHC Class II-Peptide Complexes

Endogenous Antigens: Generation of MHC Class I-Peptide Complexes

Cross-Presentation: Exogenous Antigens Presented in the MHC Class I Pathway.

Which Antigens Trigger Which T-Cell Responses?

MHC Molecules Bind Peptides Derived from Self-Molecules

Inability to Respond to an Antigen

Other Types of Antigen That Activate T-Cell Responses

Superantigens

Lipids and Glycolipids

Multiple Antigens Activate γδ T Cells

Genes of the HLA Region

Nomenclature of Polymorphic MHC Molecules

Regulation of Expression of MHC Genes

Codominant Expression

Coordinate Regulation

Inheritance of MHC Genes

MHC in Other Species

Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease

Chapter 10 Biology of the T Lymphocyte

The Antigen-Specific T-Cell Receptor

Molecules That Interact with Antigen

The T-Cell Receptor Complex

Co-Receptors

Other Important Molecules Expressed on the T-Cell Surface

γδ T Cells

Genes Coding for T-Cell Receptors

Generation of T-Cell Receptor Diversity

T-Cell Differentiation in the Thymus

The Thymus as Primary Organ for T-Cell Differentiation

Key Steps in Thymic Differentiation

Early T-Cell Receptor Gene Rearrangements: Double-Negative Cells and Splitting Off of γδ T Cells

Pre-T Cells

Double-Positive Cells

Thymic Selection

Leaving the Thymus

Generation of the T-Cell Repertoire

Characteristics of αβ T Cells Emerging from the Thymus

Further Differentiation of CD4+ and CD8+ T Cells Outside the Thymus

Differentiation of Other Cell Types in the Thymus

Chapter 11 Activation and Function of T Cells

A Two-Signal Model for the Activation of T Cells

Dendritic Cells Are the Key APC for Naïve T Cells

Activation of CD4+ T Cells.

Paired Interactions at the Surface of the APC and CD4+ T Cell.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Coico, Richard Immunology

ISBN:

9781118396902

1118396901

OCLC:

881469757