Adventures in Gut Neuroscience / Marcello Costa.

Format:

Book

Author/Creator:

Costa, Marcello, author.

Language:

English

Subjects (All):

Neurosciences--History.

Neurosciences.

Neurosciences--Research.

Physical Description:

1 online resource (226 pages)

Edition:

First edition.

Place of Publication:

Adelaide, Australia : Wakefield Press, [2023]

Summary:

Marcello Costa published his first paper in Neuro-gastroenterology in 1965. He pioneered many methods to investigate the organization and functions of the so-called 'little brain in the gut', the Enteric Nervous System. This monograph summarizes his extensive work in collaboration with close to 200 colleagues from different countries.

Contents:

Cover

Title page

Imprint

Dedication

Contents page 1

Contents page 2

Foreword

Introduction

I. An adventurous and curious boy

II. A New world

III. Return to birthplace

IV. The enteric plexuses in the 1960s

V. Histochemistry of biogenic amines and the gut

VI. First encounter with organ bath pharmacology

VII. A political student and life in the 1960s

VIII. Geoff Burnstock and the Australian adventure

IX. Overcoming the tyranny of language in Melbourne in the '70s

X. Cutting ties with Torino

XI. European interlude via South America seeking a research career

XII. Settling in Australia: from Melbourne to Adelaide

XIII. Exploring the neural bases of intestinal behaviour

Recording from enteric nuerons

Polarity of enteric nerve pathways

XIV. On the function of the enteric inhibitory motor neurons

Developing new methods for visualizing adrenergic transmitters

Beyond noradrenergic nerves: other amine neurons in the gut?

XV. In search for more unknown transmitters in the gut: 5-hydroxytryptamine

XVI. The environment at Flinders in mid 1970s

XVII. On the conceptual distinction between the pharmacology and the physiology of neurotransmitters

The era of neuropeptides in the nervous system

XVIII. Whole-mount methods for visualizing neuropeptides in the intestine

XIX. Substance P as an enteric neurotransmitter

XX. The golden decade of the 1980s: unravelling the enteric circuits

My links with a remarkable colleague

XXI. Fast (spark) and slow (soup) synaptic transmission in the nervous system

Slow synaptic transmission in the enteric nervous system

XXII. VIP and the NANC inhibitory nerves

One or more transmitters for every neuron

Multiple neuronal markers

XXIII. Visualising cholinergic neurons in the enteric nervous system (ENS).

Where are te enteric motor neurons in gut?

XXIV. Emergence of the concept of chemical coding of neurons

Plurichemical transmission

XXV. Multidisciplinary approach to unravelling enteric neural circuits

Ultrastructure of the ENS and synaptic connections

Analytical methods to confirm the biochemical nature of substances visualised by IHC.

XXVI. Beyond the gut

Other species

Travelling as a researcher to Japan

XXVII. Was our work on guinea pigs wasted?

Beyond the gut again

XXVIII. The 1990s

a decade of closures and further explorations

The gut and opioid drugs

The discovery of nitric oxide as neurotransmitter

Using the chemical coding concept to identify more functional classes of enteric neurons

Neurofilaments in enteric neurons

XXIX.F inal unravelling of the enteric circuits

the arrival of Simon Brookes

XXX. Spatial pharmacology

Mechanisms of peristalsis in the isolated guinea-pig small intestine

The first comprehensive summary of the identifiable classes of enteric neurons

XXXI. Presidency of the Australian Neuroscience Society and other adventures

Further adventures in Patagonia

Crossing waters by sailboard

Working with a giant pharmaceutical company: AstraZeneca

My links with Swedish scientists

XXXII. The Human ENS

Extending studies to the innervation of other viscera

XXXIII. Teaching administration and research

Varenna teaching slides

Cognitive science course at Flinders

XXXIV.The new millennium

beyond anatomy and physiology

spatio-temporal representation of gut movements

Modelling of peristalsis

XXXV. Back to the brain and eventually back to the gut

Return to the experimental labs

Developing the new spatio-temporal mapping methods

XXXVI. My last years: the enteric circuits in the modern era.

Conceptual issues remaining open at the end of my research career

Acknowledgements

References

Brief Curriculum Vitae

Chronology

Research productivity

Conferences

Teaching

Public Engagement

Colleagues perspectives

John Chalmers, AC FAA FAAHMS FRACP

John Furness FAA

Bill Blessing

Ian Gibbins

Judy Morris

Simon Brookes

Nick Spencer

Phil Dinning

Wakefield Press

Back cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9781923042162

1923042165