Nanoscience Applications in Diabetes Treatment / Ali Rastegari.

Format:

Book

Author/Creator:

Rastegari, Ali, author.

Language:

English

Subjects (All):

Diabetes--Treatment.

Diabetes.

Diabetes--Prevention.

Physical Description:

1 online resource (128 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., [2023]

Summary:

Nanotechnology has shown immense promise for advancing blood glucose control. This technology offers the potential to safeguard pancreatic cells from autoimmune destruction by driving the creation of innovative therapeutic agents that can be delivered to specific targets. In this book, you will find a comprehensive exploration of diabetes and its approved medical treatments. The book delves into how nanotechnology can amplify the efficacy of current treatment modalities, potentially paving the way for a gene therapy solution to combat this disease. Starting with the history of diabetes treatment, the book explains treatment challenges for diabetes before getting into the three ways nanoscience is helping in diabetes treatment: insulin delivery, drug delivery and nucleotide delivery. Each chapter is contributed by accomplished experts in their respective fields, who strive to offer a thorough, yet accessible discussion of the subject. Readership General readers, science enthusiasts and scholars interested in diabetes medicine.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Abbreviations

List of Contributors

The Story of Diabetes and its Causes

Ramin Malboosbaf1,* and Neda Hatami1

INTRODUCTION

TYPE 1 DIABETES

Role of Genetics

Role of the Environment

Infection

Dietary Factors

Natural History and Prognosis

Effects on Glucose Metabolism

Effect on Lipid Metabolism

Effects on Protein Metabolism

PATHOPHYSIOLOGY OF TYPE 2 DIABETES

Insulin-sensitive Tissues

Insulin Resistance and the Risk of Type 2 Diabetes Mellitus

Adipose Tissue and Insulin Resistance

Role of Gut Microbiome and Metabolome in Diabetes and Insulin Resistance

Role of Gut Hormones

Genetics

Environmental Influences

Sleeping

Maturity-onset Diabetes of the Young, Latent Autoimmune Diabetes of Adults, and Double Diabetes

CONCLUSION

REFERENCES

Treatment Approaches and Challenges

PHARMACOLOGIC THERAPY FOR ADULTS WITH TYPE 1 DIABETES

Insulin Therapy

PHARMACOLOGIC THERAPY FOR ADULTS WITH TYPE 2 DIABETES

NON-INSULIN TREATMENT FOR TYPE 2 DIABETES MELLITUS

Insulin Secretagogues

Sulfonylureas

Meglitinides

Amylin Analogs

Biguanides

Metformin

Insulin Sensitizers

Alpha-glucosidase Inhibitors (AGIs)

Incretin Mimetics

GLP-1 Agonists

DPP-4 Inhibitors

Sodium-glucose Co-transporter Two Inhibitors

Insulin in Type 2 Diabetes

Nanomedicine for Insulin Delivery in Diabetes

Morteza Rafiee-Tehrani1, Somayeh Handali1, Mohammad Vaziri1, Sepideh Nezhadi1 and Farid Abedin Dorkoosh1,*

NANOCARRIERS BASED INSULIN DELIVERY

Liposome

Chitosan

PLGA

Solid Lipid Nanoparticle (SLN)

Hydroxyapatite (HAP)

Nanogels

Micelle.

Dendrimer

Exosomes

Nanoscience for Drug Delivery in Diabetes

N. Vishal Gupta1,*, M. Sharadha1, K. Trideva Sastri1, Souvik Chakraborty1, Hitesh Kumar1, Vikas Jain1 and Surajit Dey2

NANOMEDICINE IN DIABETES: NEED-BASED APPROACH

Nanomedicine in the Management of Diabetes

ORGANIC MATERIAL-BASED NANOMEDICINES

Lipid-based Nanocarriers

Liposomes and Pro-liposomes

Solid Lipid Nanoparticles (SLNs)

Nanostructured Lipid Carriers (NLCs)

Nano-emulsions

Microemulsions

Nano-capsules

Self-nano-and Micro-emulsifying Drug Delivery Systems (SMEDDS and SNEDDS)

Natural Polymeric Nanoparticles

Chitosan-Based Nanoparticles

Alginate-Based Nanoparticles

Dextran-Based Nanoparticles

Synthetic Polymeric Nanoparticles

PLGA (Poly Lactic-co-Glycolic Acid) Based Nanoparticles

PLA Based Nanoparticles

Miscellaneous

Nanosuspensions

Dendrimers

Micelles

Hydrogels

INORGANIC MATERIAL-BASED NANOMEDICINE

Carbon Nanotubes (CNTs)

Metallic Nanoparticles (MNPs)

SPECIALIZED NANOMEDICINES

Natural Carrier Systems-based Nanomedicines

Erythrocytes-based Nanocarriers

Exosomes-based Nanocarriers

Phytosome-based Nanocarriers

Sphingosomes-based Nanocarriers

CHALLENGES WITH NANOMEDICINE IN THE MANAGEMENT OF DIABETES

CONCLUSION AND FUTURE PERSPECTIVES

Nanoscience for Nucleotide Delivery in Diabetes

Ali Rastegari1,*

DNA DELIVERY APPROACH

RNA DELIVERY APPROACH

FUTURE AND CHALLENGES

Subject Index

Back Cover.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815196535

OCLC:

1491309950