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Neurobiology of infectious diseases. Volume 1. / edited by Tatiana Barichello, Rodrigo Hasbun and Felipe Dal-Pizzol.
- Format:
- Book
- Series:
- Neurobiology of Disease Series
- Neurobiology of Disease Series ; v.Volume 1
- Language:
- English
- Subjects (All):
- Communicable diseases.
- Nervous system--Diseases.
- Nervous system.
- Neurobiology.
- Physical Description:
- 1 online resource (1309 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Academic Press, [2025]
- Summary:
- Neurobiology of Infectious Diseases covers mechanisms underlying infectious diseases.It is divided into six distinct sections, beginning with the foundations of Neuroinfection.This section includes chapters on the role microbiota-gut-brain axis and specialized blood-neuronal barriers play in neurobiology of infectious diseases.
- Contents:
- Front Cover
- Neurobiology of Infectious Diseases
- Copyright
- Contents
- Contributors
- Foreword
- I - Foundations of neuroinfection
- 1 - Anatomical Organization of central nervous system (CNS)
- Introduction
- The brain
- Pathogen entry into the brain
- Brain cellular composition
- Neurons
- Glial cells
- Pathogens exploit neuronal cellular processes to infiltrate the CNS
- Brain signaling and communication
- Neurotransmitters
- Pathogen and neurotransmitters
- Glutamate
- Gamma-aminobutyric acid
- Acetylcholine
- Dopamine
- Serotonin
- Anatomical arrangements of gray matter
- Cerebral cortex
- Frontal lobe
- Temporal lobe
- Parietal lobe
- Occipital lobe
- Subcortical nuclei
- Basal ganglia
- Diencephalon
- Cerebellum
- Infections in the cerebellum
- Brainstem and cranial nerves
- Midbrain
- Pons
- Medulla
- Pathogen route of entry into the brain stem
- Cranial nerve injuries
- Cranial nerves as a pathway to infection
- Meninges
- Pachymeninx
- Subarachnoid space
- Leptomeninges
- Arachnoid
- Pia
- The CNS vasculature (arterial, venous system)
- Arterial supply
- Neurovascular tree
- Vascular system and infection
- Venous system
- Pathogen infiltration in the vasculature
- CSF and the ventricular system
- Anatomy of ventricular system
- CSF functions
- The ventricular system as a route for pathogens into the CNS
- Physical barriers to the CNS
- Blood-CSF barrier
- Pathogen entry into the BCB
- The blood-brain barrier
- Infiltration of the BBB
- Spinal cord
- Pathogenic infiltration of the spinal cord
- Pathogen routes of entry into the CNS
- Infiltration into the brain
- Infiltration through the nasopharynx
- Infiltration through the sinuses
- Infiltration through the middle ear
- Summary
- References
- Further reading.
- 2 - The enteric nervous system's (ENS) impact on the neurobiology of infectious diseases
- The microbiota-gut-brain axis
- The enteric nervous system
- The "healthy" gut-microbiota
- Metabolic and CNS disorders: A consequence of dysregulated microbiota-gut-brain axis functioning
- Diet-microbiota-gut-brain axis
- Targeting the microbiome-gut-brain axis
- 3 - The role of the microbiota-gut-brain axis on the neurobiology of infectious diseases
- The microbiota-gut axis and its metabolites
- The microbiota-gut-brain axis communication pathways
- The impact of the microbiota-gut-brain axis
- The microbiota-gut-brain axis in the neurobiology of the infectious disease
- Conclusion and future directions
- 4 - The role and function of specialized blood-neuronal barriers: Blood-CSF, blood-retinal, blood-spinal cord, bloo ...
- Blood blood-brain barrier during infections
- Blood-CSF barrier and infections
- Nose-brain barrier and infections
- Blood-labyrinth barrier during infections
- Blood-nerve barrier and infections
- Blood-retinal barrier and infections
- Glymphatic system function and infections
- Conclusions
- 5 - Neuroimmune interactions in the neurobiology of infectious diseases
- Neuroimmune signaling at the brain borders
- Blood-brain barrier
- Meninges and neuroimmune interactions
- Choroid plexus
- Important components and CNS-resident cells in the neuroinflammatory process
- Cytokines and chemokines
- The complement system
- Phagocytosis and ROS production
- CNS immune-mediated inflammation
- Microglia interaction with astrocytes, oligodendrocytes, and neurons in CNS-homeostasis
- Microglia interaction with astrocytes, oligodendrocytes, neurons, and peripheral immune cells in CNS-inflammation.
- Conclusion and future directions
- Acknowledgments
- 6 - The routes and mechanisms of microbial translocation to the central nervous system
- Detecting mechanisms of microbial translocation
- Hematogenous invasion
- Transcellular
- Description
- Molecular mechanism
- Pathway 1: FAK-dependent focal adhesion redistribution (Fig. 6.1A)
- Pathway 2: Arachidonic acid-mediated cytoskeletal reorganization (Fig. 6.1B)
- Pathway 3: β-arrestin redistribution (Fig. 6.1C)
- Paracellular
- Pathway 1: Junctional protein redistribution
- Pathway 2: Production of degradatory enzymes
- Pathway 3: Cytotoxicity
- Cellular hijacking or the ``Trojan horse''
- Mechanism
- Neuronal invasion
- Olfactory transmission
- Peripheral nerves
- Further readings
- II - Bacterial infections of CNS
- 7 - Brain infections, encephalitis and meningitis: Streptococcus pneumoniae
- Streptococcus pneumoniae
- S. pneumoniae epidemiology
- S. pneumoniae identification
- S. pneumoniae virulence factors
- S. pneumoniae colonization
- S. pneumoniae transmission
- S. pneumoniae antimicrobial resistance
- S. pneumoniae prevention
- S. pneumoniae host immune defenses
- Innate immunity response
- Inflammasome
- Chemokines and cytokines
- Complement system
- Acute phase serum proteins
- Adaptive immune responses
- S. pneumoniae: From nasopharyngeal colonizer to the central nervous system pathogen
- The olfactory route
- The otogenic route
- The blood-brain barrier route
- Glial cells reactivity
- Neuronal damage
- S. pneumoniae: Meningitis and encephalitis diagnosis
- Long-term cognitive impairment after S. pneumoniae infection
- Treatment
- Managing sequelae
- Conclusion
- References.
- 8 - Brain infections, encephalitis, and meningitis: Neisseria meningitidis
- Neisseria meningitidis
- Epidemiology
- Lifecycle of N. meningitidis
- CNS Neisseria invasions that may cause brain infection, encephalitis, and meningitis pathogenesis
- Clinical features of N. meningitidis infection in adults
- Clinical features of N. meningitidis infection in children
- Diagnostic workup
- Complications
- N. meningitidis-treatment, prognosis, and prevention
- Prevention
- Prophylaxis
- 9 - Brain infection, encephalitis, and meningitis: Streptococcus agalactiae
- Streptococcus agalactiae: Colonization
- Central nervous system Streptococcus agalactiae invasion
- Recognition of Streptococcus agalactiae brain infection by innate immune sensors
- Central nervous system immune response: Streptococcus agalactiae
- The role of glial cells in encephalitis, and meningitis
- Neuronal brain injury
- Long-term behavioral sequelae
- Diagnostic, clinical signs, and symptoms
- 10 - Brain infections, encephalitis, and meningitis: Mycobacterium tuberculosis
- Vignette
- a child with Tuberculous meningitis
- Pathophysiology
- Genetic susceptibility
- Diagnosis and staging
- Vaccination
- Outcome
- Future perspectives
- the role of omics
- Further reading
- 11 - Neurosyphilis
- A brief history of syphilis
- Clinical features
- Syphilitic meningitis
- Syphilitic gumma
- Meningovascular syphilis
- Brain parenchyma involvement
- Syphilitic meningomyelitis
- Tabes dorsalis
- Peripheral nervous system involvement
- Congenital neurosyphilis
- Diagnosis
- Acquired neurosyphilis
- Congenital syphilis
- Conclusion.
- References
- 12 - Brain infections, encephalitis, and meningitis: Lyme disease-Lyme borreliosis
- Definitions
- Lyme disease
- Nervous system infection
- LB: Clinical
- LB: Diagnostics
- LNB: Clinical
- LNB: Laboratory diagnosis
- LNB treatment
- Lyme encephalopathy
- Other associations
- 13 - Brain infections, encephalitis, and meningitis: Brucelosis
- Definition of neurobrucellosis
- Pathogenesis/pathology and clinical diagnosis
- Clinical manifestations
- Blood and CSF laboratory findings
- Image diagnosis
- Microbiological diagnosis of neurobrucellosis
- Bacteriological methods
- Brucella DNA detection in CSF
- Antibodies to Brucella in CSF and serological diagnosis
- Management and treatment
- 14 - Brain infections, encephalitis, and meningitis: Listeria monocytogenes-Listeriosis
- Pathogenesis
- Survival, traversal of the intestinal barrier, and hematogenous spread
- Central nervous system invasion by Listeria
- Direct invasion of the blood-brain or blood-CSF barriers
- Transport across the barrier by infected monocytes (Trojan horse mechanism)
- Axonal migration to the brain stem
- Specific in vivo models of neurolisteriosis
- Host response in the central nervous system
- Clinical features of central nervous system infections by Listeria
- Listeria-treatment and prognosis
- Management
- Prognosis
- 15 - Sepsis-associated encephalopathy: Understanding the brain dysfunction in sepsis
- Cerebral magnetic resonance imaging or cranial computer tomography
- Evoked potentials
- Analysis of the cerebrospinal fluid
- Biomarkers
- Electroencephalogram
- Neurobiology.
- Disruption of the BBB and neuroinflammatory process.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780443191312
- 044319131X
- OCLC:
- 1477225376
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