Implementation of Personalized Precision Medicine : Expanding the Clinical Vision Towards Prevention, Early Detection and Precision Treatment of Disease to Drive Extended Healthspan.

Format:

Book

Author/Creator:

Stanford, William P.

Contributor:

Kelly DAOM, Matcm.

Language:

English

Subjects (All):

Medical care-Technological innovations.

Medical innovations.

Precision medicine.

Physical Description:

1 online resource (448 pages)

Edition:

1st ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2024.

Summary:

Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes the landscape of precision medicine as it stands in relation to implementation of individualized approaches based on the patient's unique genomic and.

Contents:

Intro

Implementation of Personalized Precision Medicine: Expanding the Clinical Vision Towards Prevention, Early Detection, and ...

Copyright

Contents

Contributors

Editors statement

Chapter 1: Epigenetics and methylation risk scores

The evolution of epigenetics in biomedical research

DNA methylation

Epigenetic technology and its application in health and disease

The emerging field of methylation risk scoring

The power of machine learning to develop predictors of disease

ML-based development of disease classifiers in clinical medicine

Applications in nononcological disease

Applications in aging: The biological clock

The clinical application of MRS in the health care setting

Limitations, challenges, and the future of clinical adoption of MRS at the point of care

Acknowledgments

References

Chapter 2: Polygenic risk scores: A conceptual overview to add PRS to your clinical toolbox

Introduction

Association, not causation

Polygenic risk scores come in all sizes

Garbage in, garbage out

Ready for clinical use

Better when were together

The promise of PRS

Chapter 3: The proteomics revolution: Forging a new path to personalized health care

Introduction: Proteomics as ``the one ring to rule them all´´

Why protein networks? And if they are so good, why didnt it happen earlier?

Proving a breakthrough

Interpreting the results: Expertise in proteomics not required

Traditional diagnostic test development vs the new discipline

what's the difference?

Physiology and utility, the chicken made the egg

Or is it that the egg made the chicken?

Getting comfortable with the unknown

The few vs the many

reductive vs expansive tensions

Eliminate the immutable

From the vein to the lab: Abuse of blood as a living tissue.

Why the cardio-metabolic portfolio bias? Why not cancer?

Where can proteomics win in cancer?

Integrated programmatic planning

Where does it go from here? Bumps on the road to widespread adoption

Overcoming the bias against predicting risk: Prognostic vs diagnostic

Countering the religion about ``concentration as truth´´

How to redefine analytic validation

Translation into clinical utility and reimbursement by insurers

Leading to a challenge to the diagnostics business model

Winds in our favor-What might accelerate the impact of proteomics in personalized medicine?

Invisible personalized medicine: Proteomics in drug development

The future: Unsupervised learning and AI

Conclusions

Chapter 4: Pharmacogenetic clinical implementation

Clinical use and considerations

Psychiatric

Gastrointestinal

Cardiovascular

Respiratory

Multimorbidity

Rheumatology

Infectious disease

The implementation of pharmacogenomics into point of care

Challenges to implementation

Cost savings with implementation of PGx

Conclusion

Chapter 5: Seeing clearly to treat precisely: Advances in molecular imaging and theranostics in precision health

Overview

Imaging across a range of scales

The tools of molecular imaging

Imaging anatomy

Imaging cellular and molecular signatures

Imaging metabolic markers

Imaging cell surface markers

Imaging immune cells for diagnosis and monitoring cellular therapeutics

AI in molecular imaging

Reporter genes

Nanomedicine

Imaging earlier in the disease course

Chapter 6: Early quantum computing applications on the path towards precision medicine

A quantum state of mind

Applying quantum computing in medicine

Genomics and clinical research

Diagnostics.

Treatments and interventions

Making it practical and useful

Chapter 7: Gene therapy: State of the art precision medicine

Current gene therapy studies in rare diseases

Risk factors and challenges of gene therapy

Immune responses

Targeting the wrong cells

Tumor formation

Ethical concern

High cost of gene therapy

Long-term impact of gene therapy

Multifactorial diseases

The future of gene therapy in rare disease

Antisense oligonucleotides, small molecule drugs, and enzyme replacement therapy

Embryo screening and prenatal gene therapy for rare diseases

Chapter 8: Precision mitochondrial medicine: Uncovering pathways across diverse diseases

The landscape of mitochondrial dysfunction

Mitochondrial structure and function

Implications of mitochondrial health in chronic diseases

Mitochondrial myopathies

Neurodegenerative diseases

Alzheimer's disease

Parkinson's disease

Cardiovascular diseases

Heart failure

Atherosclerosis

Metabolic disorders

Type 2 diabetes

Obesity

Inflammatory disorders

Rheumatoid arthritis

Inflammatory bowel disease

Cancer

Altered energy metabolism

Mitochondrial dynamics

Apoptosis

Genomic instability

Rare genetic disorders

Leigh syndrome

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes

Age-related conditions

Sarcopenia

Age-related macular degeneration

Autoimmune diseases

Systemic lupus erythematosus

Precision medicine

Addressing current challenges in progressing precision mitochondrial medicine

State-of-the-art technologies facilitating diagnosis of mitochondrial diseases

References.

Chapter 9: Antigen-specific immunotherapy: The ultimate precision medicine for the treatment of autoimmune diseases

Self/nonself-discrimination

Current treatments for autoimmune diseases

Antigen-specific immune regulation for the treatment of allergy

Lessons learned on delivery of antigens for autoimmune diseases

Therapeutic approaches suitable for the delivery of intact antigens

Therapeutic approaches based on T cell epitopes

Clinical trials of immunotherapy with apitopes

Precision medicine and antigen-specific immunotherapy

Chapter 10: The future of precision diabetes: Digital twin

Overview of diabetes: Prevalence and global impact

Biomarkers in diabetes: Current landscape

Digital twin technology in diabetes management

Digital twin technology overview

Artificial intelligence in diabetes management

Machine learning and healthcare sensor data

Whole body digital twin technology

Predictor implementation

Sensors and data collection

Twin app for personalized recommendations

Operation and support

Patent and operationalization

Data correlation and recommendations

Glycemic improvements

MAFLD improvement

Cardiovascular improvements

Improvements in complications

Additional improvements

Measures of success and future consolidation

Consolidating gains in future diabetes management

Continuous monitoring and feedback

Dynamic adjustments and early interventions

Patient education and engagement

Integration of advanced technologies

Research and development

Future directions in diabetes prevention and reversal

Chapter 11: Precision oncology: Indications and challenges in the implementation of high-throughput sequencing in clinica ...

Introduction.

Precision medicine studies in pan-cancer indications

Molecular tumor board: Definition and objectives

Levels of actionability of molecular alterations

High-throughput sequencing: Clinical applications

Challenges in interpreting NGS

Challenges in implementing NGS on a large-scale basis

Integration of big data in clinical practice: future perspectives

Annex 1: Case studies

Chapter 12: Bringing ``precision´´ to psychiatry: Challenges and promises

Identification of etiological risk factors

Identification of biological mechanisms underlying etiological risk factors using model systems

Human brain imaging and integration with genetic information

Drug discovery efforts and integration of genetic information

Artificial intelligence (AI) in the implementation of precision psychiatry

Chapter 13: Precision medicine in cardiovascular disease

Precision in cholesterol/atherosclerosis/coronary artery disease

Hypertensive heart disease

Cardiomyopathy/arrhythmias

The return to precision and personalization

Precision medicine in cardiovascular disease

Coronary artery disease (CAD)

Myocardial infarction (MI)

Hypertension

Advancements in technology provide the road to prevention

The specific case for type 2 diabetes

Chapter 14: Precision bone health: Genetic testing for low bone density

Osteoporosis is a major health concern

Bone growth is dynamic

How osteoporosis is diagnosed

Most cases of osteoporosis are undiagnosed

Genetic studies on bone mineral density and osteoporosis

Polygenic risk scores for BMD and osteoporosis

DNA testing to diagnose and treat osteoporosis

The future: P4 medicine for osteoporosis

Chapter 15: Functional nutrigenomics: A personalized shift in treating inflammation.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

0-323-97276-4

OCLC:

1474242109