Electrocardiography of Channelopathies : A Primer for the Clinical Cardiologist / Manlio F. Marquez-Murillo, editor.

Format:

Book

Contributor:

Márquez Murillo, Manlio F., editor.

Series:

Electrocardiography in Cardiac Practice Series

Language:

English

Subjects (All):

Electrocardiography--Examinations, questions, etc.

Electrocardiography.

Electrocardiography--Programmed instruction.

Physical Description:

1 online resource (228 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2025]

Summary:

Electrocardiography of Channelopathies: A Primer for the Clinical Cardiologist introduces readers to the inherited arrhythmia syndromes that are a leading cause of sudden cardiac death.

Contents:

Front Cover

ELECTROCARDIOGRAPHY OF CHANNELOPATHIES

ELECTROCARDIOGRAPHY OF CHANNELOPATHIESA PRIMER FOR THE CLINICAL CARDIOLOGISTEDITED BYMANLIO F. MÁRQUEZ-MURILLOIGNACIO CHÁVE ...

Copyright

Dedication

Contents

Contributors

Preface

1 - Introduction: An historical perspective

1. Introduction

2 - How to measure the QT interval in your office. Pitfalls to avoid

2. Correction of the QT interval. Why is it important?

3. QT interval correction formulas. Where did it come from?

4. QT interval measurement. Is there a possibility for error?

4.1 End of QT interval: It can get complicated

5. A list of common pitfalls to avoid in the measurement of QT/QTc interval

6. Specific considerations in measuring the QT interval in children

7. Conclusions

References

3 - Clinical applicability of QT formulae to correct QT interval

2. Methods for QT interval correction

3. Clinical implications of QTc intervals

4. Conclusion

4 - Usefulness of digital health devices for QT measurement and as an aid for diagnosis of channelopathies

2. Handheld ECGs for QT measurement

3. Smartwatch ECGs for QT measurement

4. Tips for the busy clinician

5 - Brief review of maneuvers to unmask the LQTS

2. Stand up test (Passive orthostatic challenge or Viskin's test)

2.1 Abnormal QT hysteresis

2.2 QT stunning

3. Exercise stress test

3.1 Which patients should undergo an exercise stress test?

3.2 What are the limitations of provocative exercise testing?

4. The epinephrine infusion challenge

4.1 Mayo Clinic protocol

4.2 Shimizu protocol

4.3 Effects of epinephrine in the QT interval

5. Adenosine test

6. Tips for the busy clinician

References.

6 - Drug-induced Torsades de Pointes and other forms of "acquired LQTS"

1. What is the difference between congenital and acquired LQTS?

2. What is the mechanism behind an acquired LQTS?

3. Risk assessment for drug-induced prolonged QT and risk of ventricular arrhythmias

4. Acquired long QT interval in the recent COVID-19 pandemic

5. Polypharmacy as a risk factor for acquired LQTS

6. Acute coronary syndromes and acquired long QT

6.1 Ischemic VT versus acquired LQTS in the setting of ischemia and the role of quinidine

7. Tips for the busy clinician

7 - ECG findings of isolated long QT syndrome 1

2. Why we should know about LQTS subtypes?

3. Representative ECG traces of LQT1

4. Alternative maneuvers

5. Tips for the busy clinician

8 - ECG findings of long QT syndrome type 2

2. Representative ECG tracings

3. Provocative maneuvers (Viskin's test)

9 - ECG findings in long QT syndrome type 3 (LQT3)

1. Definition

2. Clinical findings

2.1 NaV1.5 gain-of function phenotype

3. NaV1.5 mixed gain and loss-of function phenotype

10 - Andersen-Tawil syndrome (LQT7): A focus on ECG alterations

1. Background11Part of this chapter was adapted from the following article published in Spanish: Márquez MF, Totomoch-Serra A, ...

2. Pathophysiology

What is the role of the Kir 2.1 channel?

2.2 How is the KCNJ2 gene affected by ATS-1?

2.3 How does the abnormality of the Kir2.1 channel affect the heart?

2.4 Could there be other factors behind ATS?

3. Cardiac manifestations

3.1 Q-T interval or Q-U interval prolongation?

3.2 Characteristics of premature ventricular contractions and ventricular bigeminy in ATS-1

3.3 Ventricular arrhythmias.

4. Future perspectives

Acknowledgments

11 - The electrocardiographic spectrum of the long QT syndrome in pediatric patients

2. Representative ECG tracings (could be a 12-lead ECG, a stress-treadmill test, a holter monitoring rhythm strip, or all in s ...

3. Alternative maneuvers (Viskin's test, lidocaine test)

4. Typical and atypical ECG patterns

5. Tips in four steps for the busy clinician

12 - ECG of short QT syndrome

1.1 Genetic background and pathophysiology

1.2 Clinical manifestations

1.3 Diagnosis

2. Representative ECG tracings-ECG findings

3. Description of main ECG diagnostic findings of representative tracings

13 - High-risk electrocardiographic markers for sudden death in Brugada syndrome

2. Electrocardiographic diagnosis

3. Sudden cardiac death risk stratification

4. Brugada phenocopy

4.1 Introduction

4.2 Definition and mechanisms

4.3 Causes of Brugada phenocopy

4.4 Diagnosis

5. Conclusions

Further reading

14 - ECG in Brugada syndrome beyond ST-segment elevation: Application of the beta angle and the base of the triangle

2. Brugada ECG patterns

3. Recognizing high-risk ECG features in patients with BrS ECG pattern

4. The β-angle and the base of the triangle in clinical practice

5. Association between the β-angle and the base of the triangle with the ajmaline inducibility test

6. Clinical vignette

7. Conclusion

8. Tips for the busy clinician

15 - Electrocardiography of polymorphic ventricular tachycardia

2. Polymorphic VT associated with long QT.

3. Polymorphic VT associated with primary electric diseases without QT prolongation

3.1 Brugada syndrome

3.2 Short QT syndrome

3.3 CPVT

4. Polymorphic VT/VF associated with early repolarization syndrome

5. Idiopathic VF and short-coupled related VT/VF

6. Polymorphic VT/VF in structural heart diseases

Abbreviations

16 - Electrocardiographic diagnostics in catecholaminergic polymorphic ventricular tachycardia: ECG, Holter, and st ...

1. Introduction11Part of this chapter was adapted from the following article published: Márquez MF, Totomoch-Serra A, Rueda A, ...

2. Clinical diagnosis

3. Pathophysiology

4. Genetics of CPVT

5. ECG features

6. Holter monitoring and loop recorders

7. Treadmill stress testing: The cornerstone of diagnosis

8. Conclusions

9. Tips for the busy clinician

17 - ECG diagnosis of early repolarization pattern

1.1 Original definitions

1.2 Early repolarization syndrome

2. Current definition of early repolarization

2.1 Relevance of the slope of the ST segment

3. Representative examples

4. Population studies (epidemiology)

4.1 Is there an association of early repolarization with sudden death?

5. Debate: Early repolarization or delayed depolarization?

Index

A

B

C

D

E

F

G

H

I

K

L

M

N

P

Q

R

S

T

U

V

Back Cover.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780443223457

0443223459

OCLC:

1474241276