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Vagus Nerve Stimulation / Peter Staats [and three others], editors.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Neural stimulation.
- Neural stimulation--Data processing.
- Physical Description:
- 1 online resource (430 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Stacy Masucci, [2025]
- Summary:
- In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated.Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component.
- Contents:
- Intro
- Vagus Nerve Stimulation
- Copyright
- Dedication
- Contents
- Contributors
- Preface
- Introduction
- Section I: Why is the vagus getting so much attention
- Chapter 1: Vagus insufficiency syndrome
- Anatomy of the vagus nerve
- Explaining medically unexplained symptoms
- Traditional treatment of MUSs
- Vagus insufficiency syndrome
- History of vagus nerve stimulation
- Noninvasive VNS
- Cervical nVNS
- Headache disorders
- Episodic cluster headache
- Chronic cluster
- Acute treatment of migraine
- Prevention of migraine
- Novel diseases being studied for treatment with VNS
- Fibromyalgia
- Rheumatoid arthritis
- Sjögrens Syndrome
- Asthma
- Posttraumatic stress disorder
- Gastrointestinal dysfunction
- Anxiety and depression
- Building the rationale for vagal control of MUS
- Exploring the economic impact of MUS
- Vagus nerve stimulation in vagus insufficiency
- Conclusion
- References
- Chapter 2: Randomized controlled studies do not reflect the complexity of chronic disease, including the vagal response
- Common links to chronic illnesses
- Threat physiology
- Allostatic load
- Overall resilience of the nervous system
- Root causes
- Obstacles to treatment
- Prospective randomized studies are insufficient in defining ``standard of care´´
- An example treatment paradigm
- Overview of solutions
- Chapter 3: Vagus nerve stimulator (VNS)-What the surgeon needs to know
- Indications
- Contraindications
- VNS hardware
- Leads
- Implantable pulse generators
- LivaNova VNS implantable pulse generators
- Surgical noninplantable accessories
- Nonsurgical accessories
- De novo VNS system implantation
- Preoperative work-up
- Surgical technique
- Patient position
- Marking skin incisions (Fig. 23)
- Cervical skin incision.
- Chest skin incision
- Cervical dissection
- Vagus nerve exposure
- Wrapping lead contacts on the nerve
- Creating IPG pocket
- Lead tunneling
- Strain relief bend and loop
- Implant IPG
- System testing
- Closure
- Programming
- Postoperative regimen
- Complications
- Side effects of VNS
- MRI compatibility
- Electrosurgery
- IPG replacement
- Lead revision
- Explantation of entire VNS system
- Chapter 4: Noninvasive vagus nerve stimulation: History, mechanisms, indications, and obstacles
- Relevant anatomy of the vagus nerve
- Mechanism
- Measurement of vagus nerve function
- Part one: Cognitive approaches
- Mindfulness and biofeedback
- Deep breathing and muscle relaxation techniques
- External approaches to vagus nerve stimulation
- Cold water immersion
- Safe and sound protocol
- Vagal maneuvers
- Noninvasive vagus nerve stimulation
- Cervical vagus nerve stimulation
- Auricular vagus nerve stimulation
- Electromagnetic field therapy
- Obstacles to the use of noninvasive vagus nerve stimulation
- Technical challenges
- Variable response rates
- Device limitations
- Patient education and acceptance
- Regulatory and reimbursement issues
- Lack of long-term data
- Future directions
- Conclusions
- Chapter 5: Exploring vagus nerve stimulation through the lens of the polyvagal theory*
- Evolution and the emergence of a ventral vagal circuit
- A functional social engagement system
- Sensory pathways of the social engagement system: Potential portals to stimulate vagal function
- Vagal pathways
- Vagus nerve stimulation: Assumed mode of action
- Ventral vagal complex: A portal for vagus nerve stimulation
- Role of afferents in vagus nerve stimulation.
- Recruiting the acoustic efferent limb of the social engagement system: A portal to stimulate vagal efferent activity
- Vagal brake
- Summary
- Section II: Neurologic conditions
- Chapter 6: Vagus nerve stimulation for the management of epilepsy
- Mechanism of action
- Local effects
- Central effects
- Effects over neurochemistry, neurotransmitters, and neuroinflammatory pathways
- Clinical use and efficacy
- Closed-loop stimulation
- Quality-of-life improvement
- SUDEP and VNS
- Practical aspects of programming and maintenance of the VNS device
- Predicting treatment outcomes
- Patient selection
- Conclusions and future directions
- Chapter 7: Noninvasive vagus nerve stimulation in migraine treatment
- Migraine clinical presentation
- Migraine pathophysiology
- Migraine pharmacotherapy and limitations
- Mechanism of action of noninvasive vagus nerve stimulation
- Noninvasive vagus nerve stimulation efficacy in migraine treatment
- Noninvasive vagus nerve stimulation safety
- Migraine treatment with noninvasive vagus nerve stimulation
- Chapter 8: Vagal nerve stimulation in rare headache disorders
- History of VNS
- Epilepsy studies
- Depression studies
- Physiology of VNS in headache disorders
- Modalities of VNS
- VNS in cluster headache
- VNS in indomethacin-sensitive headaches
- VNS in SUNA/SUNCT
- Chapter 9: Vagus nerve stimulation for the management of traumatic brain injury
- The history of electrical neuromodulation
- Electroconvulsive therapy
- Deep brain stimulation
- Vagus nerve stimulation
- Cranial nerve X: Vagus nerve
- Anatomy
- Mechanisms of action
- EEG effects
- Altered neurotransmitter levels and cerebral blood flow.
- Vagus nerve stimulation in animal models of traumatic brain injury
- Pro-inflammatory cytokine overproduction following traumatic brain injury
- Vagus nerve stimulation approaches
- Implanted devices
- Placement
- Surgical approach
- Complications and side effects
- Transcutaneous
- Cervical application
- Auricular application
- Off-label uses and future applications
- tVNS for TBI: A pilot study
- Rationale for the study
- Study design
- Preliminary results
- Limitations
- Section III: Evolving therapy for neurologic conditions
- Chapter 10: Vagus nerve stimulation in acute stroke: Review based on current modalities and emerging trends
- Overview of acute strokes
- Pathophysiology of acute strokes
- Clinical manifestations and consequences
- Introduction to vagus nerve stimulation
- Historical background of VNS
- Application of VNS in neurological disorders
- VNS in acute stroke: Mechanisms and rationale
- Mechanisms underlying VNS in stroke recovery
- Rationale for using VNS in acute stroke management
- Preclinical studies supporting the use of VNS in stroke
- Overview of clinical trials investigating VNS in acute stroke patients
- Ongoing trials
- Current modalities of VNS in acute stroke
- Electrical parameters of VNS
- Clinical efficacy of VNS in acute stroke
- Summary of clinical studies evaluating the efficacy of VNS in acute stroke patients
- Analysis of outcomes such as functional recovery, neurological deficits, and quality of life
- Emerging modalities and future directions
- Noninvasive VNS techniques
- Potential advantages and limitations compared to invasive VNS
- Investigation of VNS combined with other therapeutic modalities
- Synergistic effects and rationale for combination therapies.
- Novel targets and mechanisms
- Advances in understanding the neurobiological mechanisms underlying VNS efficacy
- Predictive biomarkers
- Identification of biomarkers predicting response to VNS therapy
- Personalized medicine approaches for optimizing VNS treatment in acute stroke patients
- Chapter 11: Using vagus nerve stimulation to direct synaptic plasticity and treat neurological disease
- Summary of findings from nonclinical studies
- Rationale for the use of VNS paired with rehabilitation
- VNS paired with rehabilitative training improves recovery of motor function in multiple rat models of brain injury
- VNS paired with rehabilitative training improves recovery in rat models of SCI
- Summary of findings from clinical research
- VNS is widely used and safe
- VNS paired with rehabilitation improves recovery after neurological injury
- Chapter 12: Vagus nerve stimulation for the management of tinnitus
- Pathophysiology
- Treatments for tinnitus
- Sound paired vagus nerve stimulation for tinnitus
- How does sound paired VNS exert its clinical benefit?
- Vagus nerve stimulation and tinnitus
- Chapter 13: Vagus nerve stimulation for the management of neurodegenerative disorders
- Parkinsons disease
- Alzheimers disease
- Traumatic brain injury
- Stroke
- Mild cognitive impairment
- Chapter 14: Vagal nerve stimulation for cognitive and performance enhancement
- The historical context of VNS in medical applications
- The concept of enhancing cognition through VNS
- Anatomy and function of the vagus nerve
- Role of the vagus nerve in the autonomic nervous system.
- The connection between the vagus nerve and cognitive processes.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 0-12-816997-4
- OCLC:
- 1472989599
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