SCN2A-related disorders / edited by Alfred L. George, Jr.

Format:

Book

Contributor:

George, Alfred L., editor.

Series:

Elements in genetics in epilepsy 2633-2086.

Cambridge elements. Elements in genetics in epilepsy, 2633-2086

Language:

English

Subjects (All):

Developmental disabilities--Genetic aspects.

Developmental disabilities.

Physical Description:

1 online resource (81 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2024.

Summary:

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core

Notes:

Title from publisher's bibliographic system (viewed on 15 Nov 2024).

ISBN:

9781009530347

1009530348

9781009530354

1009530356

9781009530361

1009530364

Access Restriction:

Open Access. Unrestricted online access