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Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders : Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders / Valentina Rapozzi, Luigi Xodo, and Benjamin Bonavida, editors.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Cancer--Chemotherapy--Congresses.
- Cancer.
- Inflammation--Chemotherapy--Congresses.
- Inflammation.
- Nitric oxide--Therapeutic use--Congresses.
- Nitric oxide.
- Physical Description:
- 1 online resource (358 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Academic Press, [2025]
- Summary:
- Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or.
- Contents:
- Front Cover
- Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders
- Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
- Copyright
- Contents
- Contributors
- About the editors
- Preface
- UDINE 2023 Third International Conference
- UDINE 2023
- Table of contents
- Sponsors
- Aim and scope
- Useful information
- Program
- Speakers' abstracts
- References
- Hypothesis
- Introduction
- Aims
- Methods
- Results
- Conclusions
- Acknowledgments
- Posters' abstracts
- Alphabetical list of speakers
- Oral presentations
- Poster presentations
- Objective of this volume
- Highlights
- I - General introduction
- 1 - Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery
- Pathophysiology of CSA-AKI and NO dysregulation
- Renal vasoconstriction
- Direct free-hemoglobin and catalytic iron injury
- Ischemia-reperfusion injury
- Conflict of interest statement
- II - Nitric oxide and cancer
- 2 - The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer
- Vasculogenic mimicry: Pathogenesis and clinical significance
- Dimethylarginine dimethylaminohydrolase 1: Biology and role in vasculogenic mimicry
- Recent developments in understanding the biological role of DDAH2 and its possible effects in vasculogenic mimicry
- General considerations
- References.
- III - Nitric oxide reactions in the cells and models to check its biological properties
- 3 - Decoding S-nitrosylation: Theoretical aspects and analytical approaches
- NO signaling
- Nitric oxide in physiology and pathology
- Vasodilation and muscle cell contraction
- Neurotransmission
- Metabolism and bioenergetics
- Immune response
- Tumorigenesis
- Mutagenicity and genome instability
- Cell death
- Angiogenesis
- Epithelial-to-mesenchymal transition
- S-nitrosylation detection: Approaches and challenges
- Indirect detection assays
- The biotin-switch assay
- Direct methods: Derivatization methods
- SNO-RAC method
- Gold nanoparticles
- Organomercury resin capture
- Organophosphine-based SNO labeling
- Direct (nonderivative) methods
- Mass spectrometry
- Immunohistochemistry
- Conclusion
- Conflict of interest
- 4 - Preclinical models to assess the pharmacological properties of NO derivatives
- From preclinical to clinical trials of drugs
- Cell-based in vitro pharmacological screening and safety assessment
- Cell culture source and maintenance
- Cell survival through the MTT test
- Cell proliferation
- Adherent cell migration (scratch assay)
- Cell chemotaxis and chemoinvasion
- Gelatin zymography
- Matrigel assay to assess endothelial network formation
- Measurement of endothelial permeability
- PRP preparation and platelet aggregation
- Clonogenic assay
- 2D and 3D cocultures
- In vitro tumorsphere formation
- Ex vivo experiments
- Aortic ring preparations for vessel tone measurements
- Isolated heart preparation and perfusion
- Aortic ring angiogenesis assay
- Measurement of cGMP levels
- In vivo experiments to assess efficacy and safety of NO derivatives
- Animal maintenance and treatment
- In vivo measurement of arterial pressure and heart rate.
- Effect of NO derivatives on tumor growth
- In vivo tumor xenograft
- Safety studies before clinical studies
- Acknowledgements
- IV - Nitric oxide and neurodegeneration
- 5 - Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration
- Neurovascular oxidative and nitrergic stress
- Oxygen-mediated signaling
- Nitric oxide-mediated signaling
- Redox stress in the vascular, neuronal, and astrocytic compartments
- Smooth muscle and endothelial cells
- Neurons
- Astrocytes and pericytes
- Therapeutic targets of NO signaling
- Inhibition of NO signaling
- Activation of NO signaling
- V - Nitric oxide and therapeutics
- 6 - The role of nitric oxide in gemcitabine resistance of pancreatic cancer cells
- Nitric oxide and tumor progression
- Nitric oxide and chemoresistance in cancer cells
- Gemcitabine, the most important treatment for pancreatic cancer
- Mechanisms of action of gemcitabine
- Development and characterization of GEM-resistant BXPC-3 pancreatic cell line
- Possible interactions between NO and metabolic reprogramming in BxPC-3/GEM pancreatic cancer cells
- Discussion and future perspectives
- 7 - Exploring the dual role of nitric oxide in glioblastoma
- Treatment of GBM
- NO production and its biological process
- Role of the INOS/NO pathway in GBM
- Role of NO as tumor progressor
- Role of NO as tumor suppressor
- NO-targeted therapies in GBM
- Inhibition of NO
- Induction of NO
- Discussion
- Perspectives and future directions
- 8 - Nitric oxide donating systems and their potential in shaping tumor immunoregulation
- The tumor microenvironment.
- The enigmatic dual nature of nitric oxide in cancer
- Nitric oxide donors
- Nitric oxide donors and the immune system
- Conclusions and future directions
- 9 - Control of nitric oxide synthase 2: Role of NRF2-regulated distal enhancer
- NOS2 structure and function
- NOS2 and cancer
- Transcription factors activating NOS2 expression
- NRF2 controls the expression of NOS2
- NRF2 binds to a distal enhancer of NOS2
- PDAC-spheroids formation depends on NOS2: Therapeutic implications
- Concluding remarks
- 10 - Nitric oxide in tumor biology: From stemness to metabolic reprogramming
- Role of NO in the acquisition of stem characteristics and therapy resistance in breast cancer
- Role of NO in the biology of intestinal cancer cells
- Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer
- 11 - Impact of nitric oxide on hemeprotein maturation and its relevance to cancer and pulmonary diseases
- Impact of NO on hemeprotein maturation
- NO in cancer
- Significance of the NO-sGC-cGMP pathway in globin maturation and relevance to cancer progression
- NO in asthma and pulmonary diseases
- Conclusion and future directions
- VI - Educational session
- 12 - Using artificial intelligence to discover new cancer therapies
- Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- K
- L
- M
- N
- O
- P
- R
- S
- T
- U
- V
- Back Cover.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780443223556
- 0443223556
- 9780443223549
- 0443223548
- OCLC:
- 1507698080
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