Mechanics in Development and Disease / edited by Celeste M. Nelson, Lance A. Davidson.

Format:

Book

Contributor:

Nelson, Celeste M., editor.

Davidson, Lance.

EBSCOhost

Series:

Current topics in develomental biology ; v. 160

Language:

English

Subjects (All):

Biomechanics.

Biophysics.

Physical Description:

1 online resource (VII, 109 pages)

Place of Publication:

San Diego : Academic Press, an imprint of Elsevier, 2024.

Contents:

Front Cover

Series Page

Current Topics in Developmental Biology

Copyright

Contents

Contributors

Chapter One: Salivary gland developmental mechanics

1 Introduction

1.1 Structure and function of the salivary gland

1.2 Morphogenesis overview of the salivary gland

1.3 Cell differentiation in salivary gland development

1.4 Mechanics of salivary gland development

2 Epithelial cell mechanics in salivary gland morphogenesis

2.1 Epithelial cell adhesions

2.2 Contribution of epithelial cell adhesion to morphogenesis

2.3 Cell proliferation in salivary gland morphogenesis

2.4 Epithelial cell motility in salivary gland morphogenesis

2.5 Actomyosin contractility

3 Basement membrane mechanics in salivary gland morphogenesis

3.1 Basement membrane in the salivary gland

3.2 Adhesion between epithelial cells and the basement membrane

3.3 Patterned mechanical constraint by the basement membrane

4 Mechanical contributions by the mesenchyme

4.1 The mesenchyme of embryonic salivary gland

4.2 Mechanical properties of the mesenchyme

4.3 Mechanical constraint by the mesenchyme

5 Concluding remarks

References

Chapter Two: The fusion of physics and biology in early mammalian embryogenesis

1 Introduction to early mammalian embryogenesis: from blastulation to gastrulation

2 Blastulation

2.1 Morula compaction and polarization

2.2 Cavitation

2.3 ICM sorting

3 Implantation

3.1 Biomechanics at the endometrium-trophoblast interface

3.2 Peri-implantation epiblast development

4 Gastrulation

4.1 Germ layer specification and establishment of the body axes

5 Outlook on the future of biomechanics in embryogenesis: a role for embryo models

Acknowledgment

Chapter Three: Biophysics of morphogenesis in the vertebrate lung.

1 Introduction to the functional anatomy of the vertebrate lung

1.1 Bronchoalveolar lung of mammals

1.2 Parabronchial lung of birds

1.3 Faveolar lung of reptiles

2 Biophysics of branch initiation in the mammalian lung

2.1 Epithelial tissue structure during branch initiation

2.2 Physical forces from airway smooth muscle differentiation

2.3 Physical properties of ECM and pulmonary mesenchyme

2.4 Fluid pressure and downstream signaling

3 Active folding during branch initiation in the avian lung

3.1 Epithelial tissue structure during branch initiation

3.2 Physical properties of the ECM and pulmonary mesenchyme

4 Pressure-driven expansion of the epithelium in the lizard lung

4.1 Epithelial tissue structure during formation of faveoli

4.2 Morphogenesis of the pulmonary mesenchyme-building a rigid mesh

4.3 Fluid pressure and downstream signaling

4.4 Similarities to alveologenesis in the mammalian lung

5 Conceptual framework-mesenchyme is the architect

5.1 Material properties of the epithelium-what's the parameter space?

5.2 Softening or stiffening of the mesenchyme-how is pattern controlled?

5.3 The connections between biochemical signaling and tissue mechanics

6 Conclusions and outlook

Acknowledgments

Chapter Four: Gears of life: A primer on the simple machines that shape the embryo

1 Self-assembly and morphogenesis

1.1 The embryo as a machine

1.2 The gears of morphogenesis

2 Mechanical principles of morphogenesis

2.1 Morphogenesis requires wet cells and tissues carry out physical work

2.2 Materials and structures

2.3 Biopolymers

2.4 From solid-like elasticity to fluid-like viscosity, and all points in between

2.5 The labors of the embryo: force generation, transmission, and dissipation

3 Simple machines

3.1 Epithelial and mesenchymal sheets.

3.2 Thinning, thickening, or multilayering through cell shape change, division, extrusion, and radial intercalation

3.3 Traction, tethers, and anchors

4 Understanding morphogenesis through models

4.1 Build-a-model

4.2 Biomechanical testing

4.3 The value of simple models and biomechanical analysis

5 Lessons from embryonic and cell culture models

5.1 Coordination within and between cell multiple layers

5.2 Embryos are unlikely places to find single isolated migratory cells

5.3 Diversity in epithelial material properties exposed in "epithelial bridges"

6 Supracellular movements

6.1 Blastopore closure in Xenopus

6.2 Dorsal closure in Drosophila

6.3 Open problems in supracellular self-assembly

7 Conclusion

Back Cover.

Notes:

Electronic reproduction. Ipswich, MA Available via World Wide Web.

Other Format:

Print version: Mechanics in Development and Disease.

ISBN:

9780128240335

0128240334

Publisher Number:

90100560414

Access Restriction:

Restricted for use by site license.