Radiation therapy for benign conditions : a systematic review / Eric Jutkowitz [and ten others].

Format:

Book

Author/Creator:

Jutkowitz, Eric, author.

Language:

English

Subjects (All):

Radiotherapy--methods.

Radiotherapy.

Risk assessment.

Physical Description:

1 online resource (1 PDF file (xii, 200 pages))

Other Title:

Radiation therapy for benign conditions

Place of Publication:

Washington, DC : VA, U.S.Department of Veterans Affairs, Veterans Health Administration, Heath Systems Research, 2024.

Summary:

RT targets inflammatory parameters, impedes cell growth, and is frequently used to treat cancer. Lowdose RT has been proposed as a treatment for benign inflammatory and degenerative musculoskeletal diseases, typically when conventional therapy fails. This includes the use of RT for the treatment (or prevention) of heterotopic ossification, keloids after surgical resection, osteoarthritis, and plantar fasciitis Benign inflammatory and degenerative musculoskeletal diseases can cause physical limitations and decreased quality of life. Veterans are at increased risk for some benign inflammatory and degenerative musculoskeletal, orthopedic, and soft tissue conditions due to the physical demands and injuries related to military service. RT is commonly used for the treatment of benign diseases in Germany. Outside of Germany, RT is rarely used to treat benign conditions. The Veterans Affairs (VA) Evidence Synthesis Program (ESP) was asked by the Veterans Health Administration (VHA) National Radiation Oncology Program for an evidence review on radiation treatment for benign conditions.

Contents:

PREFACE

ACKNOWLEDGMENTS

Executive Summary

ABBREVIATIONS TABLE

BACKGROUND

METHODS

TOPIC DEVELOPMENT

KEY QUESTIONS AND PROTOCOL

SEARCHING AND STUDY SELECTION

DATA ABSTRACTION AND ASSESSMENT

SYNTHESIS AND CERTAINTY OF EVIDENCE

RESULTS

LITERATURE FLOW DIAGRAM

LITERATURE OVERVIEW

EFFECT OF RADIATION THERAPY FOR HETEROTOPIC OSSIFICATION

HETEROTOPIC OSSIFICATION AT FOLLOW-UP

EFFECT OF RADIATION THERAPY FOR KELOIDS

EFFECT OF RADIATION THERAPY FOR PLANTAR FASCIITIS

EFFECT OF RADIATION THERAPY (BRACHYTHERAPY) FOR PTERYGIUM

EFFECT OF RADIATION THERAPY (NON-BRACHYTHERAPY) FOR PTERYGIUM

EFFECT OF RADIATION THERAPY FOR OSTEOARTHRITIS

EFFECT OF RADIATION THERAPY FOR PEYRONIE'S DISEASE

EFFECT OF RADIATION THERAPY FOR DUPUYTREN'S CONTRACTURE

EFFECT OF RADIATION THERAPY FOR LEDDERHOSE DISEASE

EFFECT OF RADIATION THERAPY FOR HIDRADENITIS SUPPURATIVA

DISCUSSION

SUMMARY

STRENGTHS AND LIMITATIONS OF THE EVIDENCE BASE

IMPLICATIONS FOR VA POLICY AND PRACTICE

RESEARCH GAPS/FUTURE RESEARCH

STRENGTHS AND LIMITATIONS OF THE REVIEW PROCESS

CONCLUSIONS

REFERENCES

Appendix

APPENDIX A. SEARCH STRATEGIES

APPENDIX B. EXCLUDED STUDIES

APPENDIX C. CRITERIA USED IN QUALITY ASSESSMENTS

APPENDIX D. HETEROTOPIC OSSIFICATION

APPENDIX E. KELOIDS

APPENDIX F. PLANTAR FASCIITIS

APPENDIX G. PTERYGIUM

APPENDIX H. OSTEOARTHRITIS

APPENDIX I. PEYRONIE'S DISEASE

APPENDIX J. DUPUYTREN'S CONTRACTURE

APPENDIX K. LEDDERHOSE DISEASE

APPENDIX L. HIDRADENITIS SUPPURATIVA

APPENDIX M. PEER REVIEW DISPOSITION.

Notes:

Description based on publisher supplied metadata and other sources.